Results 11 to 20 of about 106,054 (214)
Schrödinger’s T Cells: Molecular Insights Into Stemness and Exhaustion
Frontiers in Immunology, 2021 T cell stemness and exhaustion coexist as two key contrasting phenomena during chronic antigen stimulation, such as infection, transplant, cancer, and autoimmunity.
Nancy M. Gonzalez +5 more
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International Journal of Immunopathology and Pharmacology, 2023 Background T cell exhaustion refers to a state wherein T cells become less functional as a result of their prolonged exposure to cognate antigens. A wealth of T cell exhaustion-focused research has been conducted in recent decades, transforming the ...
Ziling Liu +7 more
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Inhibitory receptors beyond T cell exhaustion
Frontiers in Immunology, 2015 Inhibitory receptors (iRs) are frequently associated with T cell exhaustion. However, the expression of iRs is also dependent on T cell differentiation and activation.
Silvia A Fuertes Marraco +7 more
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CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. [PDF]
PLoS Pathogens, 2015 Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion ...
Prakash K Gupta +16 more
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T Cell Dysfunction and Exhaustion in Cancer
Frontiers in Cell and Developmental Biology, 2020 Tumor immunotherapy is a promising therapeutic strategy for patients with advanced cancers. T cells are key mediators of antitumor function that specifically recognize and react to tumor-expressing antigens and have proven critical for cancer ...
Zhen Zhang +8 more
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Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy
Nature Communications, 2023 The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that ...
Marcel P. Trefny +26 more
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Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
Journal of Hematology & Oncology, 2023 T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector functions, immunological memory, and long-term control of pathogens.
Yannick Bulliard +4 more
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Research on strategies to inhibit CAR-T cell exhaustion [PDF]
Xin yixueImmunotherapy has achieved good efficacy in clinical anti-tumor therapy， especially chimeric antigen receptor T cell （CAR-T cell） therapy， as an emerging tumor immunotherapy， has achieved breakthrough efficacy in the clinical treatment of hematologic ...
FU Qiongyu, HAO Xinbao, TAO Shi
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Focus on T cell exhaustion: new advances in traditional Chinese medicine in infection and cancer
Chinese Medicine, 2023 In chronic infections and cancers, T lymphocytes (T cells) are exposed to persistent antigen or inflammatory signals. The condition is often associated with a decline in T-cell function: a state called “exhaustion”. T cell exhaustion is a state of T cell
Shenghao Li +4 more
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Memory T cell, exhaustion, and tumor immunity
Immunological Medicine, 2020 CD8+T cells are important in protective immunity against intracellular pathogens and tumors. In chronic infections or cancer, CD8+T cells are constantly exposed to antigens and inflammatory signals.
Makoto Ando +4 more
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