NK cells with decreased expression of multiple activating receptors is a dominant phenotype in pediatric patients with acute lymphoblastic leukemia [PDF]
Frontiers in Oncology, 2022 NK cells have unique attributes to react towards cells undergoing malignant transformation or viral infection. This reactivity is regulated by activating or inhibitory germline encoded receptors.
Lucero Valenzuela-Vázquez +45 more
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A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors [PDF]
Frontiers in ImmunologyIntroductionNatural Killer (NK) cells play a key role in both innate and adaptive immune responses against viruses and tumor cells. Their function relies on the dynamic balance between activating and inhibitory signals, which are mediated by receptors ...
Paolo Romania +13 more
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Post-translational Mechanisms Regulating NK Cell Activating Receptors and Their Ligands in Cancer: Potential Targets for Therapeutic Intervention [PDF]
Frontiers in Immunology, 2019 Efficient clearance of transformed cells by Natural Killer (NK) cells is regulated by several activating receptors, including NKG2D, NCRs, and DNAM-1.
Rosa Molfetta +3 more
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MYCN is an immunosuppressive oncogene dampening the expression of ligands for NK-cell-activating receptors in human high-risk neuroblastoma [PDF]
OncoImmunology, 2017 Neuroblastoma (NB) is the most common extracranial solid tumor occurring in childhood. Amplification of the MYCN oncogene is associated with poor prognosis. Downregulation on NB cells of ligands recognized by Natural Killer (NK) cell-activating receptors,
Elisa Brandetti +11 more
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In Vitro Culture with Interleukin-15 Leads to Expression of Activating Receptors and Recovery of Natural Killer Cell Function in Acute Myeloid Leukemia Patients [PDF]
Frontiers in Immunology, 2017 Despite recent progress in the therapeutic approach of malignant hemopathies, their prognoses remain frequently poor. Immunotherapy could open a new window of great interest in this setting.
Beatriz Sanchez-Correa +10 more
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Role of the ITAM-Bearing Receptors Expressed by Natural Killer Cells in Cancer
Frontiers in Immunology, 2022 Natural Killer (NK) cells are innate lymphoid cells (ILCs) capable of recognizing and directly killing tumor cells. They also secrete cytokines and chemokines, which participate in the shaping of the adaptive response.
Hakim Medjouel Khlifi +5 more
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Frontiers in Immunology, 2023 Natural killer (NK) cells play an important role in the early defense against tumors and virally infected cells. Their function is thought to be controlled by the balance between activating and inhibitory receptors, which often compete for the same ...
Vanna Imširović +4 more
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Gene Deficiency in Activating Fcγ Receptors Influences the Macrophage Phenotypic Balance and Reduces Atherosclerosis in Mice. [PDF]
PLoS ONE, 2013 Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients.
Beñat Mallavia +8 more
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Natural Killer Cells in the Malignant Niche of Multiple Myeloma
Frontiers in Immunology, 2022 Natural killer (NK) cells represent a subset of CD3- CD7+ CD56+/dim lymphocytes with cytotoxic and suppressor activity against virus-infected cells and cancer cells.
Ondrej Venglar +10 more
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Frontiers in Immunology, 2014 The responsiveness of natural killer (NK) cells is controlled by balancing signals from activating and inhibitory receptors. The most important ligands of inhibitory NK cell receptors are the highly polymorphic major histocompatibility complex (MHC ...
Rob J De Boer +2 more
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