Results 41 to 50 of about 464,635 (262)

The gamma delta T/NK cell product GADEKILL as a novel immunotherapeutic tool for neuroblastoma patients: role of B7H6 and BTN2A1 in tumor cell killing

Frontiers in Immunology
BackgroundAnti-GD2 monoclonal antibody effectively treats high-risk neuroblastoma (HR-NB) by recruiting NK cells for antibody-dependent cellular cytotoxicity (ADCC).
Fabio Morandi, Martina Della Lastra, Fabio Pastorino, Eleonora Ciampi, Maura Faraci, Chiara Brignole, Stefano Giardino, Irma Airoldi   +7 more
doaj   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Interaction of CD99 and its ligands regulates immunoregulatory pathways in NK cells

Frontiers in Immunology
Natural killer (NK) cells play a key role in immune defense against tumors and viral infections through a balance of activating and inhibitory receptors.
Myint Myat Thu, Myint Myat Thu, Nuchjira Takheaw, Nuchjira Takheaw, Witida Laopajon, Witida Laopajon, Watchara Kasinrerk, Watchara Kasinrerk, Supansa Pata, Supansa Pata   +9 more
doaj   +1 more source

Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.

PLoS Biology, 2016
It has recently been appreciated that NK cells exhibit many features reminiscent of adaptive immune cells. Considerable heterogeneity exists with respect to the ligand specificity of individual NK cells and as such, a subset of NK cells can respond ...
Jacquelyn Freund, Rebecca M May, Enjun Yang, Hongchuan Li, Matthew McCullen, Bin Zhang, Todd Lenvik, Frank Cichocki, Stephen K Anderson, Taku Kambayashi   +9 more
doaj   +1 more source

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques, Mariana dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior   +5 more
wiley   +1 more source

NK cell autoreactivity and autoimmune diseases

Frontiers in Immunology, 2014
Increasing evidences have pointed out the relevance of Natural Killer (NK) cells in organ specific and systemic autoimmune diseases. NK cells bear a plethora of activating and inhibiting receptors that can play a role in regulating reactivity with ...
Alessandro ePoggi, Maria Raffaella eZocchi   +1 more
doaj   +1 more source

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

Chronic NKG2D Engagement In Vivo Differentially Impacts NK Cell Responsiveness by Activating NK Receptors

Frontiers in Immunology, 2017
Immunosuppression is a typical hallmark of cancer and frequently includes perturbations of the NKG2D tumor recognition system as well as impaired signaling by other activating NK cell receptors.
Christine Koch, Christine Koch, Younghoon Kim, Tobias Zöller, Christina Born, Alexander Steinle   +5 more
doaj   +1 more source

Uncovering Inequities: The Role of Social Determinants of Health in Hospitalized Adolescents and Young Adults With Heavy Menstrual Bleeding

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Heavy menstrual bleeding (HMB) is a common condition among adolescents and young adults (AYAs) and is the leading cause of iron deficiency anemia (IDA) in this population. Growing evidence suggests that social determinants of health (SDOH) influence menstrual bleeding patterns, access to care, and treatment. However, no studies have
Maria Carter‐Febres, Cristina Tarango, Ashley Childress, Chunyan Liu, Evan Thomas, Jennifer Pomales, Eric S. Mullins   +6 more
wiley   +1 more source

The role of natural cytotoxicity receptors in various pathologies: Emphasis on Type I diabetes

Frontiers in Immunology, 2014
Natural killer (NK) cells are innate immune lymphocytes that function mainly as immune sentinels against viral infection and tumorogenesis. NK cell function is governed by inhibitory and activating signals arising from corresponding receptors.
Ofer eMandelboim, Jonatan eEnk
doaj   +1 more source