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Frontiers in Immunology, 2017 Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense.
Jiacheng Bi, Zhigang Tian, Zhigang Tian
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What Defines NK Cell Functional Fate: Phenotype or Metabolism?
Frontiers in Immunology, 2019 NK cells are capable of an array of functions that range widely from their classic anti-tumor and anti-viral cytotoxic effector functions, to their critical regulatory roles in controlling inflammatory immune responses and promoting tissue growth ...
Sophie M. Poznanski, Ali A. Ashkar
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Research Progress on NK Cell Receptors and Their Signaling Pathways
Mediators of Inflammation, 2020 Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize self and nonself depending on the balance of activating receptors and inhibitory receptors. After binding to their ligands, NK cell receptors trigger subsequent
Yingying Chen +3 more
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Frontiers in Immunology, 2021 Although T cell-recruiting CD3-binding bispecific antibodies (BiMAb) have been proven to be clinically effective for hematologic malignancies, the success of BiMAb targeting solid tumor-associated antigens (TAA) in carcinomas so far remains poor.
Karsten M. Warwas +18 more
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Frontiers in Immunology, 2023 The protective role of Natural Killer (NK) cell tumour immunosurveillance has long been recognised in colorectal cancer (CRC). However, as most patients show limited intra-tumoral NK cell infiltration, improving our ability to identify those with high NK
Carolyn Shembrey +7 more
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Frontiers in Immunology, 2021 Natural killer (NK) cells are prominent cytotoxic and cytokine-producing components of the innate immune system representing crucial effector cells in cancer immunotherapy.
Natasha Mupeta Kaweme, Fuling Zhou
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NK cell education: Physiological and pathological influences
Frontiers in Immunology, 2023 Natural killer (NK) cells represent a critical defense against viral infections and cancers. NK cells require integration of activating and inhibitory NK cell receptors to detect target cells and the balance of these NK cell inputs defines the global NK ...
Philippe Rascle +10 more
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Making a Killer: Selecting the Optimal Natural Killer Cells for Improved Immunotherapies
Frontiers in Immunology, 2021 Over the past 20 years natural killer (NK) cell-based immunotherapies have emerged as a safe and effective treatment option for patients with relapsed or refractory leukemia.
Samantha A. Barnes +5 more
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Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis.
Cell, 2022 Interest in harnessing natural killer (NK) cells for cancer immunotherapy is rapidly growing. However, efficacy of NK cell-based immunotherapy remains limited in most trials. Strategies to augment the killing efficacy of NK cells are thus much needed. In
Rongqing Pan +4 more
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Cancer Cell, 2023 Circulating tumor cells (CTCs), shed by primary malignancies, function as "seeds" for distant metastasis. However, it is still largely unknown how CTCs escape immune surveillance.
Xiaowei Liu +15 more
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