Results 11 to 20 of about 12,636,240 (404)
Journal of Leukocyte Biology, 2019 Natural Killer (NK) cells are important antiviral and anticancer effector cells. They have excellent potential for immunotherapy although impaired functions during cancer limit their effectiveness. The discovery that cellular metabolism can impact on and
C. Gardiner
semanticscholar +3 more sources
Identification of Functional Fragments in gMYL6 and the Mechanism of Improving NK Cell-Mediated Cytotoxicity [PDF]
Iranian Journal of Immunology, 2020 Background: In a previous study, the unrecognized role of gMYL6 in the up-regulation of human NK cells development and cytotoxicity was reported. Objective: To further elucidate the mechanism of action of small recombinant fragments of gMYL6 enhancing ...
Yuying Ji +4 more
doaj +1 more source
NK cell-based cancer immunotherapy: from basic biology to clinical development
Journal of Hematology & Oncology, 2021 Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activation is governed by the interaction of NK ...
Sizhe Liu +5 more
semanticscholar +1 more source
Prognostic impact of peripheral natural killer cells in primary central nervous system lymphoma
Frontiers in Immunology, 2023 BackgroundPrimary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin lymphoma with a poor prognosis. We aimed to evaluate the prognostic impact of circulating NK cells in PCNSL.Materials and methodsPatients diagnosed with ...
Zhiguang Lin +7 more
doaj +1 more source
Journal of Men's Health, 2022 Background: The elbow plank is a common exercise that can easily be done at home, but its effects on physical fitness and immunocyte function in elderly people are unknown.
Ki-Soo Lee +5 more
doaj +1 more source
NK cell exhaustion in the tumor microenvironment
Frontiers in Immunology, 2023 Natural killer (NK) cells kill mutant cells through death receptors and cytotoxic granules, playing an essential role in controlling cancer progression. However, in the tumor microenvironment (TME), NK cells frequently exhibit an exhausted status, which ...
Hao Jia +3 more
semanticscholar +1 more source
Journal of Translational Medicine, 2023 Background Nonkeratinizing nasopharyngeal carcinoma (NK-NPC) has a strong association with Epstein-Barr virus (EBV) infection. The role of NK cells and the tumor cell evolutionary trajectory in NK-NPC remain unclear.
Cuimin Chen +6 more
doaj +1 more source
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.
Trends in immunology, 2022 Natural killer (NK) cells, a crucial component of the innate immune system, have long been of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is regulated by interleukin-15 (IL-15), a cytokine in the common γ ...
Shoubao Ma, M. Caligiuri, Jianhua Yu
semanticscholar +1 more source
The Journal of Immunology, 2007 Abstract In this review, we overview the main features and functions of NK cells, focusing on their role in cell-mediated immune response to tumor cells. In parallel, we discuss the information available in the field of NK cell receptors and offer a wide general overview of functional aspects of cell targeting and killing, focusing on ...
Zamai L +7 more
openaire +6 more sources
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment.
Cell Metabolism, 2021 NK cells are central to anti-tumor immunity and recently showed efficacy for treating hematologic malignancies. However, their dysfunction in the hostile tumor microenvironment remains a pivotal barrier for cancer immunotherapies against solid tumors ...
Sophie M Poznanski +15 more
semanticscholar +1 more source