Results 11 to 20 of about 291,920 (218)

STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

Cell Reports, 2023
Summary: Natural killer (NK) cells are cytotoxic innate lymphocytes that eradicate tumor cells. Inducing durable antitumor immune responses by NK cells represents a major priority of cancer immunotherapy.
Lu Lu, Chao Yang, Xingyue Zhou, Lingling Wu, Xiaochuan Hong, Wenwen Li, Xinran Wang, Yuanqin Yang, Dongqing Cao, Ao Zhang, Wen Di, Liufu Deng   +11 more
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Human innate immune cell crosstalk induces melanoma cell senescence

OncoImmunology, 2020
Mononuclear phagocytes and NK cells constitute the first line of innate immune defense. How these cells interact and join forces against cancer is incompletely understood.
Felix Funck, Jens Pahl, Lenka Kyjacova, Lukas Freund, Stephanie Oehrl, Galina Gräbe, Silvia Pezer, Jessica C. Hassel, Jonathan Sleeman, Adelheid Cerwenka, Knut Schäkel   +10 more
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KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors

Frontiers in Immunology, 2023
IntroductionNatural Killer (NK) cells hold the potential to shift cell therapy from a complex autologous option to a universal off-the-shelf one. Although NK cells have demonstrated efficacy and safety in the treatment of leukemia, the limited efficacy ...
Alice Mac Donald, Alice Mac Donald, Delphine Guipouy, Delphine Guipouy, William Lemieux, William Lemieux, Mario Harvey, Louis-Jean Bordeleau, David Guay, Hugo Roméro, Yuanyi Li, Renaud Dion, Kathie Béland, Elie Haddad, Elie Haddad, Elie Haddad   +15 more
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Recent Advances to Augment NK Cell Cancer Immunotherapy Using Nanoparticles

Pharmaceutics, 2021
Among various immunotherapies, natural killer (NK) cell cancer immunotherapy using adoptive transfer of NK cells takes a unique position by targeting tumor cells that evade the host immune surveillance. As the first-line innate effector cell, it has been
Kwang-Soo Kim, Dong-Hwan Kim, Dong-Hyun Kim   +2 more
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Alteration in blood leukocyte profile due to exercise and its implication

Journal of Physical Fitness and Sports Medicine, 2013
Evaluation of peripheral blood leukocytes has been considered a popular window to the immune system and its response. The numeration of leukocytes has long been a practical clinical marker of acute inflammation.
Ryoichi Nagatomi
doaj   +1 more source

Nanomaterial‐Boosted Tumor Immunotherapy Through Natural Killer Cells

Advanced NanoBiomed Research, 2022
Natural killer (NK)‐cell immunotherapy as an alternative to T‐cell immunotherapy has been widely used in clinical cell immunotherapy of various tumors.
Mengsi Zhan, Yunqi Guo, Mingwu Shen, Xiangyang Shi   +3 more
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Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8+ T Cells

Advanced Science, 2023
Natural killer (NK) cells not only are innate effector lymphocytes that directly participate in tumor surveillance but are also essential helpers in the antitumor CD8+ T‐cell response.
Jiacheng Bi, Xiaomeng Jin, Chaoyue Zheng, Chen Huang, Chao Zhong, Xiaohu Zheng, Zhigang Tian, Haoyu Sun   +7 more
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NK-B cell cross talk induces CXCR5 expression on natural killer cells

iScience, 2021
Summary: B cell follicles (BCFs) in lymph nodes (LNs) are generally exempt of CD8+ T and NK cells. African green monkeys (AGMs), a natural host of simian immunodeficiency virus (SIV), display NK cell-mediated viral control in BCF.
Philippe Rascle, Béatrice Jacquelin, Caroline Petitdemange, Vanessa Contreras, Cyril Planchais, Marie Lazzerini, Nathalie Dereuddre-Bosquet, Roger Le Grand, Hugo Mouquet, Nicolas Huot, Michaela Müller-Trutwin   +10 more
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Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy

Cells
Natural killer (NK) cells have gained attention as a promising adoptive cell therapy platform for their potential to improve cancer treatments. NK cells offer distinct advantages over T-cells, including major histocompatibility complex class I (MHC-I ...
Andreia Maia, Mubin Tarannum, Joana R. Lérias, Sara Piccinelli, Luis Miguel Borrego, Markus Maeurer, Rizwan Romee, Mireia Castillo-Martin   +7 more
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Natural killer cell immunomodulation: targeting activating, inhibitory, and co-stimulatory receptor signaling for cancer immunotherapy

Frontiers in Immunology, 2015
There is compelling clinical and experimental evidence to suggest natural killer (NK) cells play a critical role in the recognition and eradication of tumors.
Cariad eChester, Cariad eChester, Katherine eFritsch, Holbrook Edwin Kohrt   +3 more
doaj   +1 more source