STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells
Cell Reports, 2023 Summary: Natural killer (NK) cells are cytotoxic innate lymphocytes that eradicate tumor cells. Inducing durable antitumor immune responses by NK cells represents a major priority of cancer immunotherapy.
Lu Lu +11 more
doaj +1 more source
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Journal of Hematology & Oncology, 2021 Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are considered as specialized immune cells that can be genetically modified to obtain capable effector cells for adoptive cellular treatment of cancer patients ...
Y. Gong +4 more
semanticscholar +1 more source
T and NK cell abundance defines two distinct subgroups of renal cell carcinoma
OncoImmunology, 2022 Renal cell carcinoma (RCC) is considered as an immunogenic cancer. Because not all patients respond to current immunotherapies, we aimed to investigate the immunological heterogeneity of RCC tumors.
Moon Hee Lee +10 more
doaj +1 more source
Current Perspectives on “Off-The-Shelf” Allogeneic NK and CAR-NK Cell Therapies
Frontiers in Immunology, 2021 Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily located in peripheral circulation and lymphoid tissues.
E. Heipertz +6 more
semanticscholar +1 more source
The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF [PDF]
, 2019 The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner.
Boon, Louis +17 more
core +6 more sources
Frontiers in Immunology, 2023 IntroductionNatural Killer (NK) cells hold the potential to shift cell therapy from a complex autologous option to a universal off-the-shelf one. Although NK cells have demonstrated efficacy and safety in the treatment of leukemia, the limited efficacy ...
Alice Mac Donald +15 more
doaj +1 more source
Antiviral treatment alters the frequency of activating and inhibitory receptor-expressing natural killer cells in chronic Hepatitis B virus infected patients [PDF]
, 2012 Natural killer (NK) cells play a critical role in innate antiviral immunity, but little is known about the impact of antiviral therapy on the frequency of NK cell subsets.
Chi, X. +12 more
core +3 more sources
Tissue Determinants of Human NK Cell Development, Function, and Residence.
Cell, 2020 Immune responses in diverse tissue sites are critical for protective immunity and homeostasis. Here, we investigate how tissue localization regulates the development and function of human natural killer (NK) cells, innate lymphocytes important for anti ...
P. Dogra +16 more
semanticscholar +1 more source
CAR‐NK cell in cancer immunotherapy; A promising frontier
Cancer Science, 2021 Chimeric antigen receptors (CARs) have a unique facet of synthetic biology and offer a paradigm shift in personalized medicine as they can use and redirect the patient's immune cells to attack cancer cells.
F. Marofi +12 more
semanticscholar +1 more source
Communicative & Integrative Biology, 2010 Natural killer (NK) cells are immune cells that lyse virally infected and tumor cells. Initially, their cytolytic capability is induced by cytokines. Subsequently, in their decision whether to kill a potential target cell, NK cells have to distinguish ...
Parisa Sinai +2 more
doaj +1 more source