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Surface Engineering of NK Cells with Poly-L-Glutamic Acid Enhances Tumor-Selective Immunotherapy Against Ovarian Cancer [PDF]
CellsNatural killer (NK) cells are promising effectors for cancer immunotherapy, as they can recognize and eliminate tumor cells without prior antigen sensitization.
Yoonbum Park +5 more
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NK Cells in Health and Disease. [PDF]
BiomedicinesNatural killer (NK) cells are cytotoxic innate lymphocytes that have a critical role in anti-viral and anti-tumour immunity [...]
Blunt MD.
europepmc +5 more sources
Immuno, 2021 NK cells are lymphocytes involved in the innate and adaptative immune response. These cells are located in peripheral blood and tissues with ample functions, from immune vigilant to tolerogenic reactions.
Jenny Valentina Garmendia +1 more
doaj +1 more source
Frontiers in Immunology, 2021 Natural killer (NK) cells are prominent cytotoxic and cytokine-producing components of the innate immune system representing crucial effector cells in cancer immunotherapy.
Natasha Mupeta Kaweme, Fuling Zhou
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The Journal of Immunology, 2007 Abstract In this review, we overview the main features and functions of NK cells, focusing on their role in cell-mediated immune response to tumor cells. In parallel, we discuss the information available in the field of NK cell receptors and offer a wide general overview of functional aspects of cell targeting and killing, focusing on ...
Zamai, L +7 more
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OncoImmunology, 2023 FcRγ-deficient natural killer (NK) cells, designated as g-NK cells, exhibit enhanced antibody-dependent cellular cytotoxicity (ADCC) capacity and increased IFN-γ and TNF-α production, rendering them promising for antiviral and antitumor responses.
Fei Gao +7 more
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Frontiers in Immunology, 2023 The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell activity.
Annerose E. Ziegler +27 more
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Umbilical cord blood as a promising source of NK cells for immunotherapy
Медицинская иммунология, 2023 Currently, a large number of studies on genetic modification of cord blood NK cells (UCB-NK) are carried out at both clinical and preclinical levels. Immunotherapy based on UCB-NK cells has great potential for antitumor therapy.
R. A. Velichinskii +8 more
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Evidence-Based Complementary and Alternative Medicine, 2004 It is believed that tumor development, outgrowth and metastasis are under the surveillance of the immune system. Although both innate and acquired immune systems play roles, innate immunity is the spearhead against tumors. Recent studies have revealed the critical role of natural killer (NK) cells in immune surveillance and that NK cell activity is ...
Takeda, Kazuyoshi, Okumura, Ko
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Frontiers in Neuroscience, 2022 BackgroundObservational studies have suggested that peripheral immune disorders are associated with amyotrophic lateral sclerosis (ALS). Previous studies predominantly focused on changes in adaptive immunity.
Zhenxiang Gong +4 more
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