Results 1 to 10 of about 274,971 (119)

Surface Engineering of NK Cells with Poly-L-Glutamic Acid Enhances Tumor-Selective Immunotherapy Against Ovarian Cancer [PDF]

Cells
Natural killer (NK) cells are promising effectors for cancer immunotherapy, as they can recognize and eliminate tumor cells without prior antigen sensitization.
Yoonbum Park, Ashok Kumar Jangid, Kyung Mu Noh, Eunha Kim, Chae Eun Lee, Kyobum Kim   +5 more
doaj   +2 more sources

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Immuno, 2021
NK cells are lymphocytes involved in the innate and adaptative immune response. These cells are located in peripheral blood and tissues with ample functions, from immune vigilant to tolerogenic reactions.
Jenny Valentina Garmendia, Juan Bautista De Sanctis   +1 more
doaj   +1 more source

Optimizing NK Cell-Based Immunotherapy in Myeloid Leukemia: Abrogating an Immunosuppressive Microenvironment

Frontiers in Immunology, 2021
Natural killer (NK) cells are prominent cytotoxic and cytokine-producing components of the innate immune system representing crucial effector cells in cancer immunotherapy.
Natasha Mupeta Kaweme, Fuling Zhou
doaj   +1 more source

g-NK cells from umbilical cord blood are phenotypically and functionally different than g-NK cells from peripheral blood

OncoImmunology, 2023
FcRγ-deficient natural killer (NK) cells, designated as g-NK cells, exhibit enhanced antibody-dependent cellular cytotoxicity (ADCC) capacity and increased IFN-γ and TNF-α production, rendering them promising for antiviral and antitumor responses.
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Loïs Coenon, Caroline Multrier, Loïc Vaillant, Tianxiang Zhang, Martin Villalba   +7 more
doaj   +1 more source

Umbilical cord blood as a promising source of NK cells for immunotherapy

Медицинская иммунология, 2023
Currently, a large number of studies on genetic modification of cord blood NK cells (UCB-NK) are carried out at both clinical and preclinical levels. Immunotherapy based on UCB-NK cells has great potential for antitumor therapy.
R. A. Velichinskii, J. D. Vavilova, A. A. Boyko, O. A. Shustova, A. I. Palamarchuk, G. M. Yusubalieva, O. N. Kucherova, M. A. Streltsova, E. I. Kovalenko   +8 more
doaj   +1 more source

The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells

Frontiers in Immunology, 2023
The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell activity.
Annerose E. Ziegler, Annerose E. Ziegler, Pia Fittje, Luisa M. Müller, Annika E. Ahrenstorf, Kerri Hagemann, Sven H. Hagen, Leonard U. Hess, Annika Niehrs, Tobias Poch, Gevitha Ravichandran, Sebastian M. Löbl, Benedetta Padoan, Sébastien Brias, Sébastien Brias, Jana Hennesen, Myrtille Richard, Laura Richert, Sven Peine, Karl J. Oldhafer, Lutz Fischer, Christoph Schramm, Christoph Schramm, Glòria Martrus, Madeleine J. Bunders, Madeleine J. Bunders, Marcus Altfeld, Sebastian Lunemann   +27 more
doaj   +1 more source

Natural killer cells-related immune traits and amyotrophic lateral sclerosis: A Mendelian randomization study

Frontiers in Neuroscience, 2022
BackgroundObservational studies have suggested that peripheral immune disorders are associated with amyotrophic lateral sclerosis (ALS). Previous studies predominantly focused on changes in adaptive immunity.
Zhenxiang Gong, Yang Liu, Fengfei Ding, Li Ba, Min Zhang   +4 more
doaj   +1 more source

T-Cell Immune Imbalance in Rheumatoid Arthritis Is Associated with Alterations in NK Cells and NK-Like T Cells Expressing CD38

Journal of Innate Immunity, 2021
Background: CD38+ NK (CD3− CD16+ CD38+ CD56+) cells were increased in rheumatoid arthritis (RA), which suppressed Treg cell differentiation. This study explored how CD38+ NK cells regulated CD4+ T-cell differentiation into Treg cells in RA.
Hongxing Wang, Kehua Fang, Weining Yan, Xiaotian Chang   +3 more
doaj   +1 more source

Potentiation of natural killer cells to overcome cancer resistance to NK cell-based therapy and to enhance antibody-based immunotherapy

Frontiers in Immunology, 2023
Natural killer (NK) cells are cellular components of the innate immune system that can recognize and suppress the proliferation of cancer cells. NK cells can eliminate cancer cells through direct lysis, by secreting perforin and granzymes, or through ...
Massimo Fantini, Philip Martin Arlen, Kwong Yok Tsang   +2 more
doaj   +1 more source

Strategies to rescue mesenchymal stem cells (MSCs) and dental pulp stem cells (DPSCs) from NK cell mediated cytotoxicity. [PDF]

PLoS ONE, 2010
BACKGROUND: The aim of this paper is to study the function of allogeneic and autologous NK cells against Dental Pulp Stem Cells (DPSCs) and Mesenchymal Stem Cells (MSCs) and to determine the function of NK cells in a three way interaction with monocytes ...
Anahid Jewett, Aida Arasteh, Han-Ching Tseng, Armin Behel, Hobie Arasteh, Wendy Yang, Nicholas A Cacalano, Avina Paranjpe   +7 more
doaj   +1 more source