Results 41 to 50 of about 580,210 (311)

Characterization of avian natural killer cells and their intracellular CD3 protein complex [PDF]

, 1994
Natural killer (NK) cell activity appears to be conserved throughout vertebrate development but NK cells have only been well characterized in mammals. Candidate NK cells have been identified in the chicken as cytoplasmic CD3+ and surface T cell receptor (
Anderson, Anderson, Bernot, Bucy, Bucy, Chan, Char, Chen, Chen, Chen, Chen, Chomczynski, Ciccone, Cihak, Coltey, Cooper, Dennert, Guillemot, Göbel, Hori, Hála, Laemmli, Lahti, Lanier, Lanier, Lillehoj, Mingari, Moretta, Myers, Nowak, Ortaldo, Phillips, Phillips, Poggi, Ratcliffe, Ritz, Rodewald, Schauenstein, Schnetzler, Sharma, Sowder, Spurr, Suzuki, Terry, Tjoelker, Trinchieri, Voss, Vujanovic, Wilson   +48 more
core   +1 more source

Identification of a porcine liver eomes-high-T-bet-low NK cell subset that resembles human liver resident NK cells [PDF]

, 2019
Natural killer (NK) cells are cells of the innate immunity and play an important role in the defense against viral infections and cancer, but also contribute to shaping adaptive immune responses. Long-lived tissue-resident NK cells have been described in
De Pelsmaeker, Steffi, Denaeghel, Sofie, Favoreel, Herman, Hermans, Leen   +3 more
core   +2 more sources

Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]

, 2015
Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni, Biron, Björklund, Brodin, Bryceson, Burns, Campbell, Cooley, Cooper, Cooper, Curti, Davies, Di Santo, Di Santo, Farag, Fehniger, Fogler, Foley, Freud, Gasser, Gilfillan, Grimm, Guethlein, Herberman, Huntington, Joncker, Kiessling, Killig, King, Kröger, Lajoie, Lanier, Leong, Ljunggren, Lowe, Lundqvist, Mancusi, McQueen, Miller, Moretta, Moretta, Moretta, Nguyen, Oevermann, Ouyang, Perussia, Phillips, Romagnani, Romee, Rosenberg, Rosenberg, Rosenberg, Ruggeri, Santoni, Stabile, Stabile, Stern, Stringaris, Thielens, Torelli, Trinchieri, Trinchieri, Vago, Valés-Gómez, Venstrom, Vivier, Whitelaw, Zorn   +67 more
core   +1 more source

Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: a deficiency of NK cells, but not an NK cell deficiency [PDF]

Blood, 2015
To the editor: Treatment of the glycosylphosphatidylinositol (GPI) anchor deficiency paroxysmal nocturnal hemoglobinuria (PNH) has been revolutionized by the use of the anti-C5 antibody eculizumab, which blocks complement-mediated hemolysis and the associated pathology.[1][1],[2][2] In addition ...
El-Sherbiny, YM, Doody, GM, Kelly, RJ, Hill, A, Hillmen, P, Cook, GP   +5 more
openaire   +3 more sources

NK cell-based tumor immunotherapy

Bioactive Materials
Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-infected cells and tumor cells. They are particularly powerful for elimination of hematological cancers, and have attracted considerable interests for therapy of ...
Hao Zhang, Li Yang, Tingting Wang, Zhen Li   +3 more
doaj   +1 more source

Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies

Genes and Diseases, 2023
Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth.
Liping Wang, Zhe Chen, Guohong Liu, Yunbao Pan   +3 more
doaj   +1 more source

Expression of CD226 is associated to but not required for NK cell education [PDF]

, 2017
DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has co-varied expression with inhibitory receptors. Since inhibitory
Bernhardt, Günter, Brodin, Petter, Chambers, Benedict J, Colonna, Marco, Gilfillan, Susan, Höglund, Petter, Kadri, Nadir, Kärre, Klas, Snäll, Johanna, Wagner, Arnika K   +9 more
core   +2 more sources

DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy [PDF]

, 2019
Natural killer (NK) cells are lymphocytes of the innate immune response characterized by their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance between activating and inhibitory signals mediated by different ...
Alonso, Corona, Arcos, María José, Bañas, Helena, Bergua, Juan M., Casas-Avilés, Ignacio, Durán, Esther, Hassouneh, Fakhri, López-Sejas, Nelson, Pera Rojas, Alejandra, Solana, Rafael, Sánchez-Correa, Beatriz, Tarazona, Raquel, Valhondo, Isabel   +12 more
core   +1 more source

NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.

, 2010
We characterized vaccine-induced cellular responses to rabies virus in naive adult volunteers. Contrary to current paradigms, we observed potent and prolonged in vitro NK cell cytokine production and degranulation responses after restimulation of PBMCs ...
Behrens, Ron H, Fooks, Anthony R, Horowitz, Amir, Okell, Lucy, Riley, Eleanor M   +4 more
core   +1 more source

Memory NK cell features exploitable in anticancer immunotherapy [PDF]

, 2019
Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone, Capuano, Cristina, Galandrini, Ricciarda, Palmieri, Gabriella, Pighi, Chiara, Santoni, Angela   +5 more
core   +2 more sources