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Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell
Journal of Immunology Research, 2020 NK cells are lymphocytes with antitumor properties and can directly lyse tumor cells in a non-MHC-restricted manner. However, the tumor microenvironment affects the immune function of NK cells, which leads to immune evasion.
Chaopin Yang +3 more
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Advanced Science, 2021 As the recognition between natural killer (NK) cells and cancer cells does not require antigen presentation, NK cells are being actively studied for use in adoptive cell therapies in the rapidly evolving armamentarium of cancer immunotherapy. In addition
Yoon‐Tae Kang +10 more
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, 2006 NK cells were initially thought to be endowed with a particular migratory pattern and to mainly circulate in the blood. The recent findings reviewed here highlight that NK cells can exhibit different predilictions for tissue compartments, i.e., lymph nodes, inflamed tissues, etc., where they can play an important role as active participants in ...
GISMONDI, Angela, SANTONI, Angela
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The Role of NK Cells and NK Cell Receptors inAutoimmune Disease
Autoimmunity, 2004 Natural killer (NK) cells are the first line of defense against infection and transformation. Additionally, NK cells can play seemingly opposite roles in autoimmune disease. Here, we summarize the functions of NK cells as both regulators and inducers of autoimmune disease. The role NK cells play depends on which cells become targets for NK cell attack.
Hyun-Bae, Jie, Nora, Sarvetnick
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Frontiers in Immunology, 2019 NK cells in the human lung respond to influenza A virus- (IAV-) infected target cells. However, the detailed functional capacity of human lung and peripheral blood NK cells remains to be determined in IAV and other respiratory viral infections.
Marlena Scharenberg +17 more
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Circulating CXCR5+ natural killer cells are expanded in patients with myasthenia gravis
Clinical & Translational Immunology, 2023 Objectives Myasthenia gravis (MG) is a classic autoantibody‐mediated disease in which pathogenic antibodies target postsynaptic membrane components, causing fluctuating skeletal muscle weakness and fatigue.
Meng‐Ru Ge +7 more
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Advances in Induced Pluripotent Stem Cell-Derived Natural Killer Cell Therapy
CellsNatural killer (NK) cells are cytotoxic lymphocytes of the innate immune system capable of killing virus-infected cells and/or cancer cells. The commonly used NK cells for therapeutic applications include primary NK cells and immortalized NK cell lines ...
Wenhua Qiao +3 more
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Development of Murine Hepatic NK Cells during Ontogeny: Comparison with Spleen NK Cells
Clinical and Developmental Immunology, 2012 The phenotype of developing liver NK cells (CD3−NK1.1+) was investigated during mouse ontogeny comparing with spleen NK cells. The highest percentage of hepatic CD27−CD11b− NK cells occurred at the fetal stage.
Xian Wu +4 more
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Lung tumor microenvironment induces specific gene expression signature in intratumoral NK cells
Frontiers in Immunology, 2013 Natural Killer (NK) cells are able to recognize and kill tumor cells, however whether they contribute to tumor immunosurveillance is still debated. Our previous studies demonstrated the presence of NK cells in human lung tumors.
Mélanie eGillard-Bocquet +22 more
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PLoS ONE, 2014 During chronic hepatitis C virus (HCV) infection, the role of intra-hepatic (IH) natural killer (NK) cells is still controversial. To clarify their functions, we investigated anti-viral and cytotoxic activity of NK cells in human fresh liver biopsies. We
Emilie Fugier +10 more
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