Results 41 to 50 of about 283,133 (120)

Role of NK cells in immune escape in patients with classical paroxysmal nocturnal haemoglobinuria

Clinical and Translational Medicine
Background Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal haematopoietic stem cell disorder. Immune escape is crucial in PNH, and our previous studies revealed that natural killer (NK) cells potential participate in the immune escape of
Chaomeng Wang, Yan Yang, Wei Wang, Liyan Li, Mengting Che, Yingying Chen, Honglei Wang, Zhaoyun Liu, Lijuan Li, Hui Liu, Rong Fu   +10 more
doaj   +1 more source

Surface Engineering of NK Cells with Poly-L-Glutamic Acid Enhances Tumor-Selective Immunotherapy Against Ovarian Cancer

Cells
Natural killer (NK) cells are promising effectors for cancer immunotherapy, as they can recognize and eliminate tumor cells without prior antigen sensitization.
Yoonbum Park, Ashok Kumar Jangid, Kyung Mu Noh, Eunha Kim, Chae Eun Lee, Kyobum Kim   +5 more
doaj   +1 more source

MACC1 facilitates the escape of nasopharyngeal carcinoma cells from killing by natural killer cells

Biotechnology & Biotechnological Equipment, 2019
This study examined the regulation of phenotype and function of natural killer (NK) cells by nasopharyngeal carcinoma (NPC) cells with metastasis-associated in colon cancer-1 (MACC1) overexpression.
Chong Zhao, Yuehua Liu, Zhuoping Liang, Huajun Feng, Sheng’en Xu   +4 more
doaj   +1 more source

Targeted immune cell therapy for hepatocellular carcinoma using expanded liver mononuclear cell-derived natural killer cells

Neoplasia: An International Journal for Oncology Research
Natural killer (NK) cells are a promising cellular therapy for T cell-refractory cancers but are frequently deficient or dysfunctional in patients with hepatocellular carcinoma (HCC).
Xin Hu, Yifang Shui, Seiichi Shimizu, Seisuke Sakamoto, Mureo Kasahara, Seiji Okada, Wen-Zhi Guo, Masayuki Fujino, Xiao-Kang Li   +8 more
doaj   +1 more source

Inhibition of TIGIT on NK cells improves their cytotoxicity and HIV reservoir eradication potential

mBio
The latent human immunodeficiency virus (HIV) reservoir presents the biggest obstacle to curing HIV chronic infection. Consequently, finding novel strategies to control the HIV reservoir is critical.
Yue Wang, Yidi Li, Jiaqi Chen, Chenxi Guo, Xiaowen Yu, Zining Zhang, Yajing Fu, Xiaoxu Han, Qinghai Hu, Haibo Ding, Hong Shang, Yongjun Jiang   +11 more
doaj   +1 more source

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

eLife, 2014
Natural killer (NK) cells belong to the innate immune system; they can control virus infections and developing tumors by cytotoxicity and producing inflammatory cytokines.
Dorothy K Sojka, Beatrice Plougastel-Douglas, Liping Yang, Melissa A Pak-Wittel, Maxim N Artyomov, Yulia Ivanova, Chao Zhong, Julie M Chase, Paul B Rothman, Jenny Yu, Joan K Riley, Jinfang Zhu, Zhigang Tian, Wayne M Yokoyama   +13 more
doaj   +1 more source

Immunoglobulin-like transcript 2 as an impaired anti-tumor cytotoxicity marker of natural killer cells in patients with hepatocellular carcinoma

Frontiers in Immunology
IntroductionNatural killer (NK) cells play a pivotal role in immune surveillance in the liver. We aimed to identify potential targets for NK cell-mediated immune intervention by revealing the functional molecules on NK cells in HCC patients.MethodsTo ...
Toshihiro Sakata, Toshihiro Sakata, Sachiyo Yoshio, Taiji Yamazoe, Taizo Mori, Eiji Kakazu, Yoshihiko Aoki, Nobuyoshi Aoyanagi, Toru Okamoto, Takanori Ito, Hidenori Toyoda, Takumi Kawaguchi, Yoshihiro Ono, Yu Takahashi, Akinobu Taketomi, Tatsuya Kanto   +15 more
doaj   +1 more source

A Type I IFN-Inducing Oncolytic Virus Improves NK Cell-Mediated Killing of Tumor Cells In Vitro Through Multiple Mechanisms

Viruses
Natural killer (NK) cell adoptive immunotherapy is a promising therapeutic approach in which NK cells perform targeted lysis of tumor cells. Oncolytic viruses are also effective cancer therapeutic agents due to their ability to selectively target and ...
Elisabeth M. Shiffer, Jeremiah L. Oyer, Alicja J. Copik, Griffith D. Parks   +3 more
doaj   +1 more source

CD56neg CD16+ cells represent a distinct mature NK cell subset with altered phenotype and are associated with adverse clinical outcome upon expansion in AML

Frontiers in Immunology
IntroductionAcute myeloid leukemia (AML) is a rare haematological cancer with poor 5-years overall survival (OS) and high relapse rate. Leukemic cells are sensitive to Natural Killer (NK) cell mediated killing.
Julia Wlosik, Julia Wlosik, Florence Orlanducci, Florence Orlanducci, Manon Richaud, Clemence Demerle, Amira Ben Amara, Amira Ben Amara, Marie-Sarah Rouviere, Marie-Sarah Rouviere, Philippe Livrati, Philippe Livrati, Laurent Gorvel, Laurent Gorvel, Marie-Anne Hospital, Nicolas Dulphy, Nicolas Dulphy, Raynier Devillier, Norbert Vey, Daniel Olive, Daniel Olive, Anne-Sophie Chretien, Anne-Sophie Chretien   +22 more
doaj   +1 more source

Feeder cell training shapes the phenotype and function of in vitro expanded natural killer cells

MedComm
Natural killer (NK) cells are candidates for adoptive cell therapy, and the protocols for their activation and expansion profoundly influence their function and fate.
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Loïs Coënon, Caroline Multrier, Loïc Vaillant, Julien Peyroux, Tianxiang Zhang, Martin Villalba   +8 more
doaj   +1 more source