Frontiers in Immunology, 2017 Clinical studies with adoptive immunotherapy using allogeneic natural killer (NK) cells showed feasibility, but also limitation regarding the transfused absolute cell numbers.
María Delso-Vallejo +3 more
doaj +1 more source
A four-stage model for murine natural killer cell development in vivo
Journal of Hematology & Oncology, 2022 Natural killer (NK) cells are the predominant innate lymphoid cells that mediate anti-viral and anti-tumor immunity. NK cells arise from hematopoietic stem cells in the bone marrow (BM) and undergo lineage specification and maturation.
Shoubao Ma +2 more
doaj +1 more source
Genetic modification and effector functions of natural killer cells in acute myeloid leukemia [PDF]
, 2006 Acute myeloid leukemia (AML) is characterized by a poor long-term outcome in the majority of patients following conventional treatment with chemotherapy.
Siegler, Uwe
core +1 more source
Bovine NK cells can produce gamma interferon in response to the secreted mycobacterial proteins ESAT-6 and MPP14 but not in response to MPB70 [PDF]
, 2005 Bovine NK cells have recently been characterized and the present study describes the interaction between NK cells, antigen-presenting cells, and secreted mycobacteriall proteins.
Jungersen, Gregers +15 more
core +1 more source
Flow cytometry analysis of cytotoxic cells in patients with chronic hepatitis C
Журнал инфектологии, 2014 In patients with chronic hepatitis C study the content of different populations of cytotoxic lymphocytes by flow cytometry. There was a significant decrease in functional capacity of NK -cells in determining the expression of CD 107 a picture of the ...
M. S. Selkova
doaj +1 more source
Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects
Engineering, 2019 Natural killer (NK) cells are key innate immune cells that provide the first line of defense against viral infection and cancer. Although NK cells can discriminate between “self” and “non-self,” recognize abnormal cells, and eliminate transformed cells ...
Yuan Hu, Zhigang Tian, Cai Zhang
doaj +1 more source
Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]
, 2013 Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Gregson, John NS +5 more
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Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]
, 2007 Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten +34 more
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Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: a deficiency of NK cells, but not an NK cell deficiency [PDF]
Blood, 2015 To the editor: Treatment of the glycosylphosphatidylinositol (GPI) anchor deficiency paroxysmal nocturnal hemoglobinuria (PNH) has been revolutionized by the use of the anti-C5 antibody eculizumab, which blocks complement-mediated hemolysis and the associated pathology.[1][1],[2][2] In addition ...
El-Sherbiny, YM +5 more
openaire +3 more sources
Activation of human natural killer cells by Plasmodium falciparum [PDF]
, 2003 The purpose of work described in this thesis was to (i) determine the contribution of innate immune responses to the early pro-inflammatory cytokine response to Plasmodium falciparum, (ii) describe the kinetics and ...
Artavanis-Tsakonas, Katerina
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