Results 31 to 40 of about 275,021 (166)

High Metabolic Function and Resilience of NKG2A-Educated NK Cells

Frontiers in Immunology, 2020
Natural killer (NK) cells are an important component of the innate immune system for the control of intracellular pathogens and cancer cells. NK cells demonstrate heterogeneous expression of inhibitory surface receptors.
Andrew J. Highton, Björn-Philipp Diercks, Franziska Möckl, Gloria Martrus, Jürgen Sauter, Alexander H. Schmidt, Madeleine J. Bunders, Christian Körner, Andreas H. Guse, Marcus Altfeld   +9 more
doaj   +1 more source

Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: a deficiency of NK cells, but not an NK cell deficiency [PDF]

Blood, 2015
To the editor: Treatment of the glycosylphosphatidylinositol (GPI) anchor deficiency paroxysmal nocturnal hemoglobinuria (PNH) has been revolutionized by the use of the anti-C5 antibody eculizumab, which blocks complement-mediated hemolysis and the associated pathology.[1][1],[2][2] In addition ...
El-Sherbiny, YM, Doody, GM, Kelly, RJ, Hill, A, Hillmen, P, Cook, GP   +5 more
openaire   +3 more sources

CAR-NK cells derived from cord blood originate mainly from CD56−CD7+CD34−HLA-DR−Lin− NK progenitor cells

Molecular Therapy: Methods & Clinical Development
Cord blood (CB)-derived chimeric antigen receptor (CAR)-natural killer (NK) cells targeting CD19 have been shown to be effective against B cell malignancies.
Tansri Wibowo, Yosuke Kogue, Shunya Ikeda, Moto Yaga, Mana Tachikawa, Makiko Suga, Shuhei Kida, Kumi Shibata, Kazuhito Tsutsumi, Hiraku Murakami, Yasutaka Ueda, Hisashi Kato, Kentaro Fukushima, Jiro Fujita, Tomoaki Ueda, Shinsuke Kusakabe, Akihisa Hino, Michiko Ichii, Chihaya Imai, Daisuke Okuzaki, Atsushi Kumanogoh, Naoki Hosen   +21 more
doaj   +1 more source

Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56brightCD16+NKp80+/-In-Vitro and Express KIR2DL2/DL3 and KIR3DL1

Frontiers in Immunology, 2021
The differentiation of human induced pluripotent stem cells (hiPSCs) into T and natural killer (NK) lymphocytes opens novel possibilities for developmental studies of immune cells and in-vitro generation of cell therapy products.
Johanna Euchner, Johanna Euchner, Jasmin Sprissler, Jasmin Sprissler, Toni Cathomen, Toni Cathomen, Daniel Fürst, Daniel Fürst, Hubert Schrezenmeier, Hubert Schrezenmeier, Klaus-Michael Debatin, Klaus Schwarz, Klaus Schwarz, Kerstin Felgentreff   +13 more
doaj   +1 more source

NK cell receptor profiling of endometrial and decidual NK cells reveals pregnancy-induced adaptations

Frontiers in Immunology
Natural killer (NK) cells, with a unique NK cell receptor phenotype, are abundantly present in the non-pregnant (endometrium) and pregnant (decidua) humanuterine mucosa.
Dorien Feyaerts, Marilen Benner, Gaia Comitini, Wijs Shadmanfar, Olivier W.H. van der Heijden, Irma Joosten, Renate G. van der Molen   +6 more
doaj   +1 more source

Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies

Stem Cell Research & Therapy, 2020
Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers.
Keerthana Shankar, Christian M. Capitini, Krishanu Saha   +2 more
doaj   +1 more source

Optimizing NK-92 serial killers: gamma irradiation, CD95/Fas-ligation, and NK or LAK attack limit cytotoxic efficacy

Journal of Translational Medicine, 2022
Background The NK cell line NK-92 and its genetically modified variants are receiving attention as immunotherapies to treat a range of malignancies. However, since NK-92 cells are themselves tumors, they require irradiation prior to transfer and are ...
Lydia Navarrete-Galvan, Michael Guglielmo, Judith Cruz Amaya, Julie Smith-Gagen, Vincent C. Lombardi, Rebecca Merica, Dorothy Hudig   +6 more
doaj   +1 more source

Leukoreduction filter derived NK cells offer a promising source for off the shelf CAR NK cell immunotherapy

Scientific Reports
Immunotherapy employing natural killer (NK) cells has emerged as a transformative approach to treating hematological malignancies. The reprogramming of NK cells by incorporating a chimeric antigen receptor (CAR) equipped with potent signaling domains has
Ali Moazzeni, Maryam Kheirandish, Gholamreza Khamisipour, Fatemeh Rahbarizadeh, Ali Akbar Pourfathollah   +4 more
doaj   +1 more source

PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE

Медицинская иммунология, 2017
Natural killer (NK) cells represent a lymphocyte subpopulation which is capable of contact cytolysis of virus-infected cells and tumor cells, being a source of cytokines which stimulate other immune cells and promote immune response.
V. A. Mikhailova, K. L. Belyakova, S. A. Selkov, D. I. Sokolov   +3 more
doaj   +1 more source

Prognostic significance of natural killer cell-associated markers in gastric cancer: quantitative analysis using multiplex immunohistochemistry

Journal of Translational Medicine, 2021
Background Natural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim of this study was to investigate the prognostic significance and functional implication of NK cell-associated surface ...
Hee Young Na, Yujun Park, Soo Kyung Nam, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Kyu Sang Lee, Hye Seung Lee   +9 more
doaj   +1 more source