Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects
Engineering, 2019 Natural killer (NK) cells are key innate immune cells that provide the first line of defense against viral infection and cancer. Although NK cells can discriminate between “self” and “non-self,” recognize abnormal cells, and eliminate transformed cells ...
Yuan Hu, Zhigang Tian, Cai Zhang
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Phenotypic and Functional Plasticity of CXCR6+ Peripheral Blood NK Cells
Frontiers in Immunology, 2022 Human NK cells are comprised of phenotypic subsets, whose potentially unique functions remain largely unexplored. C-X-C-motif-chemokine-receptor-6 (CXCR6)+ NK cells have been identified as phenotypically immature tissue-resident NK cells in mice and ...
Laura S. Angelo +6 more
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Human natural killer cell committed thymocytes and their relation to the T cell lineage. [PDF]
, 1993 Recent studies have demonstrated that mature natural killer (NK) cells can be grown from human triple negative (TN; CD3-, CD4-, CD8-) thymocytes, suggesting that a common NK/T cell precursor exists within the thymus that can give rise to both NK cells ...
Lanier, LL +3 more
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Flow cytometry analysis of cytotoxic cells in patients with chronic hepatitis C
Журнал инфектологии, 2014 In patients with chronic hepatitis C study the content of different populations of cytotoxic lymphocytes by flow cytometry. There was a significant decrease in functional capacity of NK -cells in determining the expression of CD 107 a picture of the ...
M. S. Selkova
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High Metabolic Function and Resilience of NKG2A-Educated NK Cells
Frontiers in Immunology, 2020 Natural killer (NK) cells are an important component of the innate immune system for the control of intracellular pathogens and cancer cells. NK cells demonstrate heterogeneous expression of inhibitory surface receptors.
Andrew J. Highton +9 more
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Uterine natural killer cell heterogeneity: Lessons from mouse models [PDF]
, 2020 Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes.
Sojka, Dorothy K
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Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients [PDF]
, 2015 Natural Killer (NK) cells are a key component of tumor immunosurveillance and thus play an important role in rituximab-dependent killing of lymphoma cells via an antibody-dependent cellular cytotoxicity (ADCC) mechanism.
Battella, Simone +13 more
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Antiviral treatment alters the frequency of activating and inhibitory receptor-expressing natural killer cells in chronic Hepatitis B virus infected patients [PDF]
, 2012 Natural killer (NK) cells play a critical role in innate antiviral immunity, but little is known about the impact of antiviral therapy on the frequency of NK cell subsets.
Chi, X. +12 more
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Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells
Scientific Reports, 2020 Osteoclasts (OCs) and much less dendritic cells (DCs) induce significant expansion and functional activation of NK cells, and furthermore, the OC-expanded NK cells preferentially increase the expansion and activation of CD8+ T cells by targeting CD4+ T ...
Kawaljit Kaur +4 more
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NK cell inflammation in the clinical outcome of colorectal carcinoma
Frontiers in Medicine, 2015 The ability of natural killer (NK) cells to provide protection against myeloid leukemia has been demonstrated in clinical settings. However, whether NK cells play a role in the clinical course of solid tumors is debated.
Andrea eCoppola +8 more
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