Results 31 to 40 of about 283,133 (120)
Медицинская иммунология, 2017 Natural killer (NK) cells represent a lymphocyte subpopulation which is capable of contact cytolysis of virus-infected cells and tumor cells, being a source of cytokines which stimulate other immune cells and promote immune response.
V. A. Mikhailova +3 more
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Journal of Translational Medicine, 2022 Background The NK cell line NK-92 and its genetically modified variants are receiving attention as immunotherapies to treat a range of malignancies. However, since NK-92 cells are themselves tumors, they require irradiation prior to transfer and are ...
Lydia Navarrete-Galvan +6 more
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Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell
Journal of Immunology Research, 2020 NK cells are lymphocytes with antitumor properties and can directly lyse tumor cells in a non-MHC-restricted manner. However, the tumor microenvironment affects the immune function of NK cells, which leads to immune evasion.
Chaopin Yang +3 more
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EZH2 identifies the precursors of human natural killer cells with trained immunity
Cancer Biology & Medicine, 2021 Objective: Trained immunity of natural killer (NK) cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after preactivation.
Chen Zhang +16 more
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Circulating CXCR5+ natural killer cells are expanded in patients with myasthenia gravis
Clinical & Translational Immunology, 2023 Objectives Myasthenia gravis (MG) is a classic autoantibody‐mediated disease in which pathogenic antibodies target postsynaptic membrane components, causing fluctuating skeletal muscle weakness and fatigue.
Meng‐Ru Ge +7 more
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Frontiers in Immunology, 2019 NK cells in the human lung respond to influenza A virus- (IAV-) infected target cells. However, the detailed functional capacity of human lung and peripheral blood NK cells remains to be determined in IAV and other respiratory viral infections.
Marlena Scharenberg +17 more
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Advances in Induced Pluripotent Stem Cell-Derived Natural Killer Cell Therapy
CellsNatural killer (NK) cells are cytotoxic lymphocytes of the innate immune system capable of killing virus-infected cells and/or cancer cells. The commonly used NK cells for therapeutic applications include primary NK cells and immortalized NK cell lines ...
Wenhua Qiao +3 more
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Development of Murine Hepatic NK Cells during Ontogeny: Comparison with Spleen NK Cells
Clinical and Developmental Immunology, 2012 The phenotype of developing liver NK cells (CD3−NK1.1+) was investigated during mouse ontogeny comparing with spleen NK cells. The highest percentage of hepatic CD27−CD11b− NK cells occurred at the fetal stage.
Xian Wu +4 more
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Lung tumor microenvironment induces specific gene expression signature in intratumoral NK cells
Frontiers in Immunology, 2013 Natural Killer (NK) cells are able to recognize and kill tumor cells, however whether they contribute to tumor immunosurveillance is still debated. Our previous studies demonstrated the presence of NK cells in human lung tumors.
Mélanie eGillard-Bocquet +22 more
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PLoS ONE, 2014 During chronic hepatitis C virus (HCV) infection, the role of intra-hepatic (IH) natural killer (NK) cells is still controversial. To clarify their functions, we investigated anti-viral and cytotoxic activity of NK cells in human fresh liver biopsies. We
Emilie Fugier +10 more
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