Results 21 to 30 of about 283,133 (120)

Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies

Genes and Diseases, 2023
Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth.
Liping Wang, Zhe Chen, Guohong Liu, Yunbao Pan   +3 more
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NK cell-based tumor immunotherapy

Bioactive Materials
Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-infected cells and tumor cells. They are particularly powerful for elimination of hematological cancers, and have attracted considerable interests for therapy of ...
Hao Zhang, Li Yang, Tingting Wang, Zhen Li   +3 more
doaj   +1 more source

NK cell inflammation in the clinical outcome of colorectal carcinoma

Frontiers in Medicine, 2015
The ability of natural killer (NK) cells to provide protection against myeloid leukemia has been demonstrated in clinical settings. However, whether NK cells play a role in the clinical course of solid tumors is debated.
Andrea eCoppola, Roberto eArriga, Davide eLauro, Maria Ilaria eDel Principe, Francesco eBuccisano, Luca eMaurillo, Patrizia ePalomba, Adriano eVenditti, Giuseppe eSconocchia   +8 more
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CAR-NK cells derived from cord blood originate mainly from CD56−CD7+CD34−HLA-DR−Lin− NK progenitor cells

Molecular Therapy: Methods & Clinical Development
Cord blood (CB)-derived chimeric antigen receptor (CAR)-natural killer (NK) cells targeting CD19 have been shown to be effective against B cell malignancies.
Tansri Wibowo, Yosuke Kogue, Shunya Ikeda, Moto Yaga, Mana Tachikawa, Makiko Suga, Shuhei Kida, Kumi Shibata, Kazuhito Tsutsumi, Hiraku Murakami, Yasutaka Ueda, Hisashi Kato, Kentaro Fukushima, Jiro Fujita, Tomoaki Ueda, Shinsuke Kusakabe, Akihisa Hino, Michiko Ichii, Chihaya Imai, Daisuke Okuzaki, Atsushi Kumanogoh, Naoki Hosen   +21 more
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NK cell receptor profiling of endometrial and decidual NK cells reveals pregnancy-induced adaptations

Frontiers in Immunology
Natural killer (NK) cells, with a unique NK cell receptor phenotype, are abundantly present in the non-pregnant (endometrium) and pregnant (decidua) humanuterine mucosa.
Dorien Feyaerts, Marilen Benner, Gaia Comitini, Wijs Shadmanfar, Olivier W.H. van der Heijden, Irma Joosten, Renate G. van der Molen   +6 more
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Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies

Stem Cell Research & Therapy, 2020
Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers.
Keerthana Shankar, Christian M. Capitini, Krishanu Saha   +2 more
doaj   +1 more source

On‐Chip Biogenesis of Circulating NK Cell‐Derived Exosomes in Non‐Small Cell Lung Cancer Exhibits Antitumoral Activity

Advanced Science, 2021
As the recognition between natural killer (NK) cells and cancer cells does not require antigen presentation, NK cells are being actively studied for use in adoptive cell therapies in the rapidly evolving armamentarium of cancer immunotherapy. In addition
Yoon‐Tae Kang, Zeqi Niu, Thomas Hadlock, Emma Purcell, Ting‐Wen Lo, Mina Zeinali, Sarah Owen, Venkateshwar G. Keshamouni, Rishindra Reddy, Nithya Ramnath, Sunitha Nagrath   +10 more
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Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56brightCD16+NKp80+/-In-Vitro and Express KIR2DL2/DL3 and KIR3DL1

Frontiers in Immunology, 2021
The differentiation of human induced pluripotent stem cells (hiPSCs) into T and natural killer (NK) lymphocytes opens novel possibilities for developmental studies of immune cells and in-vitro generation of cell therapy products.
Johanna Euchner, Johanna Euchner, Jasmin Sprissler, Jasmin Sprissler, Toni Cathomen, Toni Cathomen, Daniel Fürst, Daniel Fürst, Hubert Schrezenmeier, Hubert Schrezenmeier, Klaus-Michael Debatin, Klaus Schwarz, Klaus Schwarz, Kerstin Felgentreff   +13 more
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Leukoreduction filter derived NK cells offer a promising source for off the shelf CAR NK cell immunotherapy

Scientific Reports
Immunotherapy employing natural killer (NK) cells has emerged as a transformative approach to treating hematological malignancies. The reprogramming of NK cells by incorporating a chimeric antigen receptor (CAR) equipped with potent signaling domains has
Ali Moazzeni, Maryam Kheirandish, Gholamreza Khamisipour, Fatemeh Rahbarizadeh, Ali Akbar Pourfathollah   +4 more
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Prognostic significance of natural killer cell-associated markers in gastric cancer: quantitative analysis using multiplex immunohistochemistry

Journal of Translational Medicine, 2021
Background Natural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim of this study was to investigate the prognostic significance and functional implication of NK cell-associated surface ...
Hee Young Na, Yujun Park, Soo Kyung Nam, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Kyu Sang Lee, Hye Seung Lee   +9 more
doaj   +1 more source