Results 1 to 10 of about 25,438 (199)

Trichinella spiralis serine proteinase enhances antibody-dependent cell-mediated (ADCC) killing of newborn larvae by driving M1 polarization via the NF-κB pathway [PDF]

Parasite
Previous studies have shown that recombinant Trichinella spiralis serine proteinase (rTsSPc) promoted larval invasion of the gut epithelium, but its regulatory role on macrophage polarization is not clear.
Wu Jin Yi, Zhang Ru, Zhang Yao, Zhang Xin Zhuo, Xu Dong Mei, Liu Ruo Dan, Long Shao Rong, Wang Zhong Quan, Cui Jing   +8 more
doaj   +2 more sources

Determinants of natural killer cell-mediated antibody dependent cellular cytotoxicity in SARS-CoV-2 antibodies. [PDF]

PLoS Pathogens
A growing body of evidence underscores the role of antibody-dependent cellular cytotoxicity (ADCC) in antiviral immunity. Yet, the mechanisms underlying the ability of certain antibodies (Abs) to mediate potent ADCC activity remain poorly characterized ...
Delphine M Depierreux, Felicitas Ruiz, Michelle Lilly, Jamie Guenthoer, Vrasha Chohan, Julie Overbaugh   +5 more
doaj   +2 more sources

ADCC Assay Protocol

Bio-Protocol, 2014
Antibody-dependent cell-mediated cytotoxicity (ADCC) bridges innate and adaptive immunity, and it involves both humoral and cellular immune responses.
Vikram Srivastava, Zheng Yang, Ivan Hung, Jianqing Xu, Bojian Zheng, Mei-Yun Zhang   +5 more
doaj   +2 more sources

FcγR Binding and ADCC Activity of Human IgG Allotypes

Frontiers in Immunology, 2020
Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and IgG3 through the IgG-Fc-receptor (
Steven W De Taeye, Arthur E H Bentlage, Mirjam Mebius   +2 more
exaly   +3 more sources

Antibody-Dependent Cellular Cytotoxicity (ADCC)-Mediating Antibodies Constrain Neutralizing Antibody Escape Pathway

Frontiers in Immunology, 2019
Both neutralization and antibody-dependent cellular cytotoxicity (ADCC) may be required for effective protection against HIV-1 infection. While there is extensive information on the targets of early neutralizing antibody (nAb) responses, much less is ...
Dieter Mielke, Gama P Bandawe, Justin Pollara   +2 more
exaly   +3 more sources

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC [PDF]

Nature Communications
HIV-1 envelope glycoproteins (Env) from primary HIV-1 isolates typically adopt a pretriggered “closed” conformation that resists to CD4-induced (CD4i) non-neutralizing antibodies (nnAbs) mediating antibody-dependent cellular cytotoxicity (ADCC).
Jonathan Richard, Michael W. Grunst, Ling Niu, Marco A. Díaz-Salinas, Li Zhu, William D. Tolbert, Lorie Marchitto, Fei Zhou, Catherine Bourassa, Hongil Kim, Sri Lakshmi Tejaswi Boodapati, Derek Yang, Ta Jung Chiu, Hung-Ching Chen, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Suneetha Gottumukkala, Wenwei Li, Katrina Dionne, Étienne Bélanger, Debashree Chatterjee, Halima Medjahed, Wayne A. Hendrickson, Joseph Sodroski, Zabrina C. Lang, Abraham J. Morton, Rick K. Huang, Doreen Matthies, Amos B. Smith, Priti Kumar, Walther Mothes, James B. Munro, Marzena Pazgier, Andrés Finzi   +33 more
doaj   +2 more sources

Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response

OncoImmunology, 2021
The antibody-dependent cellular cytotoxicity (ADCC) effector function of natural killer (NK) cells is one of the known mechanisms of action for rituximab-based anti-cancer immunotherapy.
Dhon Roméo Makanga, Maxime Jullien, Gaëlle David, Nolwenn Legrand, Catherine Willem, Léa Dubreuil, Alexandre Walencik, Cyrille Touzeau, Thomas Gastinne, Benoit Tessoulin, Steven Le Gouill, Béatrice Mahé, Katia Gagne, Patrice Chevallier, Béatrice Clemenceau, Christelle Retière   +15 more
doaj   +1 more source

Vpu puts the brakes on ADCC [PDF]

Nature Reviews Microbiology, 2014
exaly   +2 more sources

Distinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast

Scientific Reports, 2022
Adenoid cystic carcinoma (AdCC) of the breast is a rare indolent carcinoma of salivary gland-type tumors, frequently associated with MYB genetic alteration.
Juan Ji, Fang Zhang, Fanglei Duan, Hong Yang, Jun Hou, Yang Liu, Jie Dai, Qiong Liao, Xian Chen, Qingsong Liu   +9 more
doaj   +1 more source

Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy

npj Breast Cancer, 2022
Breast adenoid cystic carcinoma (AdCC) is a rare subtype of triple negative breast cancer. Two morphologic variants are described, namely classic AdCC (C-AdCC) and solid basaloid (SB-AdCC).
Anne Grabenstetter, Edi Brogi, Hong Zhang, Pedram Razavi, Jorge S. Reis-Filho, Kimberly J. VanZee, Larry Norton, Hannah Y. Wen   +7 more
doaj   +1 more source