Results 1 to 10 of about 26,923 (115)

Evaluating Fc-mediated antibody functions against SARS-CoV-2 in PLHIV: reduced FcγRIIIa-dependent activity and ADCC despite preserved neutralising antibodies [PDF]

Frontiers in Immunology
BackgroundAntibody-dependent cellular cytotoxicity (ADCC) is a critical Fc-mediated immune mechanism contributing to antiviral defence. However, its functionality in people living with HIV (PLHIV) following SARS-CoV-2 exposure remains poorly understood ...
Swarali Kurle, Pratiksha Pansambal, Madhuri Thakar, Manisha Ghate, Shubhangi Bichare, Pallavi Shidhaye, Sumit Aggarwal   +6 more
doaj   +2 more sources

How past transient viremia shape natural killer cells’ antibody-dependent functions in youth with perinatal HIV [PDF]

iScience
Summary: Despite effective antiretroviral therapy, people living with HIV (PLWH) may experience transient viremia episodes, which may impact Natural Killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC).
Arianna Rotili, Chiara Pighi, Alessandro Pucci, Alessia Neri, Giuseppe Rubens Pascucci, Nicole Colantoni, Stefania Bernardi, Elena Morrocchi, Federica Betto, Silvia Di Cesare, Donato Amodio, Mathias Lichterfeld, Nicola Cotugno, Paolo Palma   +13 more
doaj   +2 more sources

Determinants of natural killer cell-mediated antibody dependent cellular cytotoxicity in SARS-CoV-2 antibodies. [PDF]

PLoS Pathogens
A growing body of evidence underscores the role of antibody-dependent cellular cytotoxicity (ADCC) in antiviral immunity. Yet, the mechanisms underlying the ability of certain antibodies (Abs) to mediate potent ADCC activity remain poorly characterized ...
Delphine M Depierreux, Felicitas Ruiz, Michelle Lilly, Jamie Guenthoer, Vrasha Chohan, Julie Overbaugh   +5 more
doaj   +2 more sources

Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response

OncoImmunology, 2021
The antibody-dependent cellular cytotoxicity (ADCC) effector function of natural killer (NK) cells is one of the known mechanisms of action for rituximab-based anti-cancer immunotherapy.
Dhon Roméo Makanga, Maxime Jullien, Gaëlle David, Nolwenn Legrand, Catherine Willem, Léa Dubreuil, Alexandre Walencik, Cyrille Touzeau, Thomas Gastinne, Benoit Tessoulin, Steven Le Gouill, Béatrice Mahé, Katia Gagne, Patrice Chevallier, Béatrice Clemenceau, Christelle Retière   +15 more
doaj   +1 more source

Do Instabilities in National Macroeconomic Factors Contribute to Channeling Volatility Spillover from the Global to the Islamic Equity Market?

Comparative Economic Research, 2021
This study investigates the impact of macroeconomic instabilities on returns volatility spillover that is transmitted from the global to the Islamic equity market.
Harjum Muharam, Najmudin Najmudin, Wisnu Mawardi, Erman Denny Arfinto   +3 more
doaj   +1 more source

Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy

npj Breast Cancer, 2022
Breast adenoid cystic carcinoma (AdCC) is a rare subtype of triple negative breast cancer. Two morphologic variants are described, namely classic AdCC (C-AdCC) and solid basaloid (SB-AdCC).
Anne Grabenstetter, Edi Brogi, Hong Zhang, Pedram Razavi, Jorge S. Reis-Filho, Kimberly J. VanZee, Larry Norton, Hannah Y. Wen   +7 more
doaj   +1 more source

Distinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast

Scientific Reports, 2022
Adenoid cystic carcinoma (AdCC) of the breast is a rare indolent carcinoma of salivary gland-type tumors, frequently associated with MYB genetic alteration.
Juan Ji, Fang Zhang, Fanglei Duan, Hong Yang, Jun Hou, Yang Liu, Jie Dai, Qiong Liao, Xian Chen, Qingsong Liu   +9 more
doaj   +1 more source

BAFF receptor antibody for mantle cell lymphoma therapy

OncoImmunology, 2021
Mantle cell lymphoma (MCL) is an aggressive form of B cell non-Hodgkin’s lymphoma and remains incurable under current treatment modalities. One of the main reasons for treatment failure is the development of drug resistance.
Keman Zhang, Nand K Roy, Yorleny Vicioso, Janghee Woo, Rose Beck, Marcos de Lima, Paolo Caimi, Daniel Feinberg, Reshmi Parameswaran   +8 more
doaj   +1 more source

MICA/B-targeted antibody promotes NK cell–driven tumor immunity in patients with intrahepatic cholangiocarcinoma

OncoImmunology, 2022
The major histocompatibility complex-class I chain related proteins A and B (MICA/B) is upregulated because of cellular stress and MICA/B shedding by cancer cells causes escape from NKG2D recognition favoring the emergence of cancers. Cholangiocarcinoma (
Barbara Oliviero, Stefania Varchetta, Dalila Mele, Greta Pessino, Roberta Maiello, Monica Falleni, Delfina Tosi, Matteo Donadon, Cristiana Soldani, Barbara Franceschini, Guido Torzilli, Gaetano Piccolo, Matteo Barabino, Enrico Opocher, Marcello Maestri, Stefano Bernuzzi, Kai W. Wucherpfennig, Mario U. Mondelli, Stefania Mantovani   +18 more
doaj   +1 more source

Modulation of anti-tumour immunity by XPO1 inhibitors [PDF]

Exploration of Targeted Anti-tumor Therapy
Exportin-1 (XPO1) is a nuclear export protein that, when overexpressed, can facilitate cancer cell proliferation and survival and is frequently overexpressed or mutated in cancer patients.
Jack G. Fisher, Laura G. Bartlett, Trinayan Kashyap, Christopher J. Walker, Salim I. Khakoo, Matthew D. Blunt   +5 more
doaj   +1 more source