Results 1 to 10 of about 182,918 (112)

BAT6026, a novel anti-OX40 antibody with enhanced antibody dependent cellular cytotoxicity effect for cancer immunotherapy [PDF]

Frontiers in Oncology, 2023
OX40 (CD134), a member of the TNF receptor superfamily, is a widely studied costimulatory immune checkpoint. Several OX40 agonistic antibodies are in the clinical stage for cancer treatment, among which PF-04518600 is the leader and currently in phase II
Shizhong Liang, Dandan Zheng, Xiong Liu, Xiong Mei, Congcong Zhou, Cuizhen Xiao, Chao Qin, Haitao Yue, Jian Lin, Cuihua Liu, Shengfeng Li, Jin-Chen Yu   +11 more
doaj   +2 more sources

Influenza A Virus Antibodies with Antibody-Dependent Cellular Cytotoxicity Function

Viruses, 2020
Influenza causes millions of cases of hospitalizations annually and remains a public health concern on a global scale. Vaccines are developed and have proven to be the most effective countermeasures against influenza infection.
Rongyuan Gao, Zizhang Sheng, Chithra C. Sreenivasan, Dan Wang, Feng Li   +4 more
doaj   +3 more sources

Determinants of natural killer cell-mediated antibody dependent cellular cytotoxicity in SARS-CoV-2 antibodies. [PDF]

PLoS Pathogens
A growing body of evidence underscores the role of antibody-dependent cellular cytotoxicity (ADCC) in antiviral immunity. Yet, the mechanisms underlying the ability of certain antibodies (Abs) to mediate potent ADCC activity remain poorly characterized ...
Delphine M Depierreux, Felicitas Ruiz, Michelle Lilly, Jamie Guenthoer, Vrasha Chohan, Julie Overbaugh   +5 more
doaj   +2 more sources

SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular Cytotoxicity [PDF]

Viruses, 2022
Viruses use many different strategies to evade host immune responses. In the case of SARS-CoV-2, its Spike mutates rapidly to escape from neutralizing antibodies.
Guillaume Beaudoin-Bussières, Ariana Arduini, Catherine Bourassa, Halima Medjahed, Gabrielle Gendron-Lepage, Jonathan Richard, Qinghua Pan, Zhen Wang, Chen Liang, Andrés Finzi   +9 more
doaj   +2 more sources

The Anti-SLAMF7 Antibody, Elotuzumab, Induces Antibody-Dependent Cellular Cytotoxicity Against CLL Cell Lines [PDF]

Molecules
SLAMF7, also known as CD319, a SLAM (signaling lymphocytic activation molecule) family receptor, is relatively weakly expressed on chronic lymphocytic leukemia (CLL) B cells.
Dominik Kľoc, Bianca Dubiková, Simona Žiláková, Ján Sykora, Michaela Šuliková, Slavomír Kurhajec, Ján Sabo, Tomáš Guman, Marek Šarišský   +8 more
doaj   +2 more sources

Natural killer cell antibody‐dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission [PDF]

Clinical & Translational Immunology
Objectives Natural killer (NK) cells make important contributions to anti‐malarial immunity through antibody‐dependent cellular cytotoxicity (ADCC), but the role of different components of this pathway in promoting NK cell activation remains unclear ...
Stephen Tukwasibwe, Savannah Nicole Lewis, Yoweri Taremwa, Kattria van derPloeg, Kathleen D Press, Maureen Ty, Felistas Namirimu Nankya, Kenneth Musinguzi, Evelyn Nansubuga, Florian Bach, Martin Chamai, Martin Okitwi, Gerald Tumusiime, Annettee Nakimuli, Francesco Colucci, Moses R Kamya, Joaniter I Nankabirwa, Emmanuel Arinaitwe, Bryan Greenhouse, Grant Dorsey, Philip J Rosenthal, Isaac Ssewanyana, Prasanna Jagannathan   +22 more
doaj   +2 more sources

Potentiating Antibody-Dependent Cellular Cytotoxicity in Triple-Negative Breast Cancer via the Humanized Anti-CD147 Antibody [PDF]

Antibodies
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with high metastatic potential, poor prognosis, and the absence of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2).
Kanyarat Thongheang, Thanathat Pamonsupornwichit, Kanokporn Sornsuwan, On-anong Juntit, Tawan Chokepaichitkool, Weeraya Thongkum, Umpa Yasamut, Chatchai Tayapiwatana   +7 more
doaj   +2 more sources

Harnessing the immunomodulatory effects of exercise to enhance the efficacy of monoclonal antibody therapies against B-cell haematological cancers: a narrative review

Frontiers in Oncology, 2023
Therapeutic monoclonal antibodies (mAbs) are standard care for many B-cell haematological cancers. The modes of action for these mAbs include: induction of cancer cell lysis by activating Fcγ-receptors on innate immune cells; opsonising target cells for ...
Harrison D. Collier-Bain, Frankie F. Brown, Frankie F. Brown, Adam J. Causer, Annabelle Emery, Rebecca Oliver, Rebecca Oliver, Sally Moore, James Murray, James E. Turner, James E. Turner, John P. Campbell   +11 more
doaj   +1 more source

Contribution of Fc-dependent cell-mediated activity of a vestigial esterase-targeting antibody against H5N6 virus infection

Emerging Microbes and Infections, 2020
The highly pathogenic avian influenza A (H5N6) virus has caused sporadic human infections with a high case fatality rate. Due to the continuous evolution of this virus subtype and its ability to transmit to humans, there is an urgent need to develop ...
Zhiqiang Zheng, Su Hui Catherine Teo, Suganya Cheyyatraivendran Arularasu, Zhehao Liu, Nur Khairiah Mohd-Ismail, Chee Keng Mok, Chee Bing Ong, Justin Jang-hann Chu, Yee-Joo Tan   +8 more
doaj   +1 more source

An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity

Nature Communications, 2023
The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent ...
Nina E. Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O’Toole, Elizabeth Whalen, Peter W. Y. Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E. Atkinson, Jason Baardsnes, Liam J. Worrall, Duncan Browman, Emma E. Smith, Priya Baichoo, Chi Wing Cheng, Joy Guedia, Sohyeong Kang, Abhishek Mukhopadhyay, Lisa Newhook, Anders Ohrn, Prajwal Raghunatha, Matteo Zago-Schmitt, Joseph D. Schrag, Joel Smith, Patricia Zwierzchowski, Joshua M. Scurll, Vincent Fung, Sonia Black, Natalie C. J. Strynadka, Michael R. Gold, Leonard G. Presta, Gordon Ng, Surjit Dixit   +38 more
doaj   +1 more source