Results 1 to 10 of about 78,706 (112)

Virus particle-based antibody-dependent cellular phagocytosis assay for HIV [PDF]

Frontiers in Immunology
IntroductionAntibodies mediate a wide range of antiviral functions, including neutralization and diverse Fc-dependent effector activities. Among these, antibody-dependent cellular phagocytosis (ADCP) has emerged as an important mechanism contributing to ...
Chitra Upadhyay, Priyanka Gadam Rao
doaj   +2 more sources

Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses [PDF]

Frontiers in Immunology, 2019
Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody–antigen immune ...
Matthew Zirui Tay, Kevin Wiehe, Justin Pollara, Justin Pollara   +3 more
doaj   +2 more sources

Antibody-dependent cellular phagocytosis in cancer immunotherapy: research and perspectives [PDF]

Journal of Translational Medicine
Background Cancer immunotherapy has revolutionized the clinical management of cancer due to its promising survival benefits. Although FDA-approved cancer immunotherapy primarily leverages adaptive immunity for therapeutic efficacy, the critical role of ...
Qihong Gu, Siqi Li, Shiqiang Hou, Jiahao Liu, Xinyang Zhang, Yan Xi, Hongzhao Chen, Songbai Liu, Minjie Chu, Minfeng Yang   +9 more
doaj   +2 more sources

Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41 [PDF]

Frontiers in Immunology, 2020
Antibodies mediate a broad array of non-neutralizing Fc-mediated functions against HIV-1 including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).
Maxence Duchemin, Maxence Duchemin, Maxence Duchemin, Daniela Tudor, Daniela Tudor, Daniela Tudor, Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +11 more
doaj   +2 more sources

CLEC5a-directed bispecific antibody for effective cellular phagocytosis

mAbs, 2022
While antibody-dependent cellular phagocytosis mediated by activating Fcγ receptor is a key mechanism underlying many antibody drugs, their full therapeutic activities can be restricted by the inhibitory Fcγ receptor IIB (FcγRIIB).
Vivekananda Kedage, Diego Ellerman, Mingjian Fei, Wei-Ching Liang, Gu Zhang, Eric Cheng, Juan Zhang, Yongmei Chen, Haochu Huang, Wyne P. Lee, Yan Wu, Minhong Yan   +11 more
doaj   +3 more sources

Protocol for assessing antibody-dependent cellular phagocytosis by primary murine and human macrophages [PDF]

STAR Protocols
Summary: Macrophages play a crucial role in mediating antibody-dependent cellular phagocytosis (ADCP), a process that enhances the effectiveness of several cancer immunotherapies. In this protocol, we outline detailed steps for isolating, differentiating,
Carlo Miguel Sevilla, Andrew Mijacika, Bella Somoza, Juan C. Osorio   +3 more
doaj   +2 more sources

Promoting antibody-dependent cellular phagocytosis for effective macrophage-based cancer immunotherapy. [PDF]

Sci Adv, 2022
Cao X, Cao X, Chen J, Li B, Dang J, Zhang W, Zhong X, Wang C, Raoof M, Sun Z, Yu J, Fakih MG, Feng M.   +12 more
europepmc   +2 more sources

Analysis and Fine Specificity of the HCMV-Specific Cell-Free and Cell-Associated Antibody-Dependent Cellular Phagocytosis (ADCP) Responses in Lung Transplant Recipients. [PDF]

Int J Mol Sci, 2021
Eberhard S, Vietzen H, Görzer I, Jaksch P, Puchhammer-Stöckl E.   +4 more
europepmc   +2 more sources

An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity

Nature Communications, 2023
The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent ...
Nina E. Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O’Toole, Elizabeth Whalen, Peter W. Y. Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E. Atkinson, Jason Baardsnes, Liam J. Worrall, Duncan Browman, Emma E. Smith, Priya Baichoo, Chi Wing Cheng, Joy Guedia, Sohyeong Kang, Abhishek Mukhopadhyay, Lisa Newhook, Anders Ohrn, Prajwal Raghunatha, Matteo Zago-Schmitt, Joseph D. Schrag, Joel Smith, Patricia Zwierzchowski, Joshua M. Scurll, Vincent Fung, Sonia Black, Natalie C. J. Strynadka, Michael R. Gold, Leonard G. Presta, Gordon Ng, Surjit Dixit   +38 more
doaj   +1 more source

Harnessing the immunomodulatory effects of exercise to enhance the efficacy of monoclonal antibody therapies against B-cell haematological cancers: a narrative review

Frontiers in Oncology, 2023
Therapeutic monoclonal antibodies (mAbs) are standard care for many B-cell haematological cancers. The modes of action for these mAbs include: induction of cancer cell lysis by activating Fcγ-receptors on innate immune cells; opsonising target cells for ...
Harrison D. Collier-Bain, Frankie F. Brown, Frankie F. Brown, Adam J. Causer, Annabelle Emery, Rebecca Oliver, Rebecca Oliver, Sally Moore, James Murray, James E. Turner, James E. Turner, John P. Campbell   +11 more
doaj   +1 more source