Results 1 to 10 of about 4,565 (121)

Analysis and Fine Specificity of the HCMV-Specific Cell-Free and Cell-Associated Antibody-Dependent Cellular Phagocytosis (ADCP) Responses in Lung Transplant Recipients. [PDF]

Int J Mol Sci, 2021
Human Cytomegalovirus (HCMV) may cause severe infections in transplant recipients. HCMV-replication can be limited by HCMV-specific antibody responses. The impact of the antibody-dependent cellular phagocytosis (ADCP) on inhibition of HCMV-replication in natural infections has not been clarified.
Eberhard S, Vietzen H, Görzer I, Jaksch P, Puchhammer-Stöckl E.   +4 more
europepmc   +6 more sources

Nef and Vpu protect infected cells from ADCP mediated by plasma from people with HIV-1 [PDF]

mBio
The HIV-1 envelope glycoprotein (Env) represents the only viral antigen at the surface of infected cells, making it an ideal target for antibody-based therapies. Most antibodies elicited in people with HIV (PWH) do not recognize Env in its native “closed”
Étienne Bélanger, Alexandra Tauzin, Fitsumbrhan Tajebe, Monika Chandravanshi, Derek Yang, Hung-Ching Chen, Ta-Jung Chiu, Catherine Bourassa, Halima Medjahed, William D. Tolbert, Madeleine Durand, Jonathan Richard, Donna M. Huryn, Simona Stäger, Marzena Pazgier, Andrés Finzi   +15 more
doaj   +2 more sources

Virus particle-based antibody-dependent cellular phagocytosis assay for HIV [PDF]

Frontiers in Immunology
IntroductionAntibodies mediate a wide range of antiviral functions, including neutralization and diverse Fc-dependent effector activities. Among these, antibody-dependent cellular phagocytosis (ADCP) has emerged as an important mechanism contributing to ...
Chitra Upadhyay, Priyanka Gadam Rao
doaj   +2 more sources

Antibody-dependent cellular phagocytosis in cancer immunotherapy: research and perspectives [PDF]

Journal of Translational Medicine
Background Cancer immunotherapy has revolutionized the clinical management of cancer due to its promising survival benefits. Although FDA-approved cancer immunotherapy primarily leverages adaptive immunity for therapeutic efficacy, the critical role of ...
Qihong Gu, Siqi Li, Shiqiang Hou, Jiahao Liu, Xinyang Zhang, Yan Xi, Hongzhao Chen, Songbai Liu, Minjie Chu, Minfeng Yang   +9 more
doaj   +2 more sources

Evaluating varicella-zoster virus vaccine immunogenicity through Fc-mediated antibody functions: the roles of ADCP and ADCC [PDF]

npj Vaccines
Assessing the functional activity of vaccine-induced antibodies is critical for evaluating immunogenicity. We developed and validated antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC) assays to quantify ...
Sivilay Xayaheuang, Ji-Young Hwang, Yunhwa Kim, Kyung-Min Lee, Seok-Tae Choi, Eun-Jeong Jang, Ji-Soo Lim, Ji Young Bang, Han Sol Lee, Ok Sarah Shin, Ji Yun Noh, So-Hee Hong, Hosun Park   +12 more
doaj   +2 more sources

Complement-mediated ADCP as a distinct and finite cytotoxic mechanism of monoclonal antibodies [PDF]

Frontiers in Immunology
IntroductionMacrophage phagocytosis is a major cytotoxic mechanism for therapeutic monoclonal antibodies (mAbs) that opsonize target cells. This antibody-dependent cellular phagocytosis (ADCP) can occur via the Fcγ or complement pathways, but the ...
Carly M. Van Wagoner, Carly M. Van Wagoner, Jonathan J. Pinney, Hanna M. Sovinski, Brett P. Ransegnola, Brett P. Ransegnola, Nydia Jaimes-Delgadillo, Nydia Jaimes-Delgadillo, Charles C. Chu, Charles C. Chu, Clive S. Zent, Clive S. Zent, Michael R. Elliott, Michael R. Elliott   +13 more
doaj   +2 more sources

Serum concentration of antigen-specific IgG can substantially bias interpretation of antibody-dependent phagocytosis assay readout

iScience, 2023
Summary: Because virus neutralization cannot solely explain vaccine-induced, antibody-mediated protection, antibody effector functions are being considered as a potential correlate of protection (CoP).
Russell St. Germain, Emily L. Bossard, Lawrence Corey, Anton M. Sholukh   +3 more
doaj   +1 more source

Fc-mediated functions of nirsevimab complement direct respiratory syncytial virus neutralization but are not required for optimal prophylactic protection

Frontiers in Immunology, 2023
IntroductionNirsevimab is an extended half-life (M252Y/S254T/T256E [YTE]-modified) monoclonal antibody to the pre-fusion conformation of the respiratory syncytial virus (RSV) Fusion protein, with established efficacy in preventing RSV-associated lower ...
Tyler Brady, Corinne Cayatte, Tiffany L. Roe, Scott D. Speer, Hong Ji, LeeAnn Machiesky, Tianhui Zhang, Deidre Wilkins, Kevin M. Tuffy, Elizabeth J. Kelly   +9 more
doaj   +1 more source

Coronavac inactivated vaccine triggers durable, cross-reactive Fc-mediated phagocytosis activities

Emerging Microbes and Infections, 2023
Although humoral responses elicited by infection or vaccine lost the ability to prevent transmission against Omicron, vaccine-induced antibodies may still contribute to disease attenuation through Fc-mediated effector functions.
Lili Wang, Chuang Li, Wanting Li, Liwei Zhao, Tiantian Zhao, Lin Chen, Ming Li, Jing Fan, Jiayan Li, Chao Wu, Yuxin Chen   +10 more
doaj   +1 more source

Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41

Frontiers in Immunology, 2020
Antibodies mediate a broad array of non-neutralizing Fc-mediated functions against HIV-1 including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).
Maxence Duchemin, Maxence Duchemin, Maxence Duchemin, Daniela Tudor, Daniela Tudor, Daniela Tudor, Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Andréa Cottignies-Calamarte, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +11 more
doaj   +1 more source