Results 31 to 40 of about 4,584 (134)

Development of combinatorial antibody therapies for diffuse large B cell lymphoma

Frontiers in Medicine, 2022
Diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma, is typically treated with chemotherapy combined with the immunotherapy rituximab, an antibody targeting the B cell receptor, CD20.
Eric S. Geanes, Stacey A. Krepel, Rebecca McLennan, Stephen Pierce, Stephen Pierce, Santosh Khanal, Todd Bradley, Todd Bradley, Todd Bradley, Todd Bradley   +9 more
doaj   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier, Sandra Szu‐Wei Hwang, Anthony F. Rullo   +2 more
wiley   +1 more source

CoronaVac-induced antibodies that facilitate Fc-mediated neutrophil phagocytosis track with COVID-19 disease resolution

Emerging Microbes and Infections
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants raise concerns about decreased vaccine efficacy, vaccines continue to confer robust protection in humans, implying that immunity beyond neutralization contributes to vaccine ...
Chuang Li, Jie Yu, Rahma Issa, Lili Wang, Mingzhe Ning, Shengxia Yin, Jie Li, Chao Wu, Yuxin Chen   +8 more
doaj   +1 more source

Despite delayed kinetics, people living with HIV achieve equivalent antibody function after SARS-CoV-2 infection or vaccination

Frontiers in Immunology, 2023
The kinetics of Fc-mediated functions following SARS-CoV-2 infection or vaccination in people living with HIV (PLWH) are not known. We compared SARS-CoV-2 spike-specific Fc functions, binding, and neutralization in PLWH and people without HIV (PWOH ...
Boitumelo M. Motsoeneng, Boitumelo M. Motsoeneng, Nelia P. Manamela, Nelia P. Manamela, Haajira Kaldine, Haajira Kaldine, Prudence Kgagudi, Prudence Kgagudi, Tandile Hermanus, Tandile Hermanus, Frances Ayres, Frances Ayres, Zanele Makhado, Zanele Makhado, Thandeka Moyo-Gwete, Thandeka Moyo-Gwete, Mieke A. van der Mescht, Fareed Abdullah, Fareed Abdullah, Michael T. Boswell, Veronica Ueckermann, Theresa M. Rossouw, Shabir A. Madhi, Shabir A. Madhi, Shabir A. Madhi, Penny L. Moore, Penny L. Moore, Penny L. Moore, Simone I. Richardson, Simone I. Richardson   +29 more
doaj   +1 more source

Preclinical Target Animal Safety Evaluation of Veterinary Monoclonal Antibodies: Principles, Methods, and Interpretation

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Monoclonal antibodies (mAbs) represent a rapidly expanding pharmaceutical class in veterinary medicine, with several products now authorized for use in dogs and cats. Limited published articles and veterinarian exposure to the principles of drug development present challenges in interpreting published safety evaluations that inform product ...
Adam Werts, Matthew Kuhn, Lauren Bessey, Alicia Braxton Hickman, Emily Chory, John Mitchell, Kirby Pasloske   +6 more
wiley   +1 more source

Protocol for assessing antibody-dependent cellular phagocytosis by primary murine and human macrophages

STAR Protocols
Summary: Macrophages play a crucial role in mediating antibody-dependent cellular phagocytosis (ADCP), a process that enhances the effectiveness of several cancer immunotherapies. In this protocol, we outline detailed steps for isolating, differentiating,
Carlo Miguel Sevilla, Andrew Mijacika, Bella Somoza, Juan C. Osorio   +3 more
doaj   +1 more source

SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal

Journal of Hematology & Oncology, 2022
A novel recombinant SIRPα-Fc fusion protein, IMM01, was constructed and produced using an in-house developed CHO-K1 cell expression system, and the anti-tumor mechanism of IMM01 targeting the CD47-SIRPα pathway was explored. The phagocytosis and in vitro
Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang, Wenzhi Tian   +16 more
doaj   +1 more source

Influenza Vaccination Results in Differential Hemagglutinin Stalk-Specific Fc-Mediated Functions in Individuals Living With or Without HIV

Frontiers in Immunology, 2022
Influenza virus hemagglutinin (HA) stalk-specific antibodies have been shown to potently induce Fc-mediated effector functions which are important in protection from disease.
Boitumelo M. Motsoeneng, Boitumelo M. Motsoeneng, Nisha Dhar, Nisha Dhar, Marta C. Nunes, Marta C. Nunes, Florian Krammer, Florian Krammer, Shabir A. Madhi, Shabir A. Madhi, Shabir A. Madhi, Penny L. Moore, Penny L. Moore, Penny L. Moore, Penny L. Moore, Penny L. Moore, Simone I. Richardson, Simone I. Richardson   +17 more
doaj   +1 more source

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source