Results 1 to 10 of about 42,056 (305)

EGFR‐Induced and c‐Src‐Mediated CD47 Phosphorylation Inhibits TRIM21‐Dependent Polyubiquitylation and Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, 2023
Tumor cells often overexpress immune checkpoint proteins, including CD47, for immune evasion. However, whether or how oncogenic activation of receptor tyrosine kinases, which are crucial drivers in tumor development, regulates CD47 expression is unknown.
Linyong Du, Ying Meng, Daqian Xu
exaly   +3 more sources

Regulation of CD47 expression in cancer cells

Translational Oncology, 2020
CD47 is overexpressed in various types of cancers and it can directly bind with SIRPα, which is mainly located on macrophages. The binding of CD47-SIRPα transmits a “don't eat me” signal, which can prevent cancer cells from immune clearance.
Jin-Jian Lu
exaly   +5 more sources

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes [PDF]

Journal of Neuroinflammation, 2011
Background Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops.
Reichert Fanny, Oldenborg Per-Arne, Liraz-Zaltsman Sigal, Gitik Miri, Rotshenker Shlomo   +4 more
doaj   +4 more sources

The antitumor activities of anti-CD47 antibodies require Fc-FcγR interactions

Cancer Cell, 2023
While anti-CD47 antibodies hold promise for cancer immunotherapy, early-phase clinical trials have shown limited clinical benefit, suggesting that CD47 blockade alone might be insufficient for effective tumor control.
Juan C Osorio, David A Knorr
exaly   +2 more sources

Association between CD47 expression, clinical characteristics and prognosis in patients with advanced non‐small cell lung cancer

Cancer Medicine, 2020
Objective CD47 is an antiphagocytic molecule that contributes to tumor cell resistance in host immune surveillance. CD47 overexpression correlated with tumor progression and shorter survival in lung cancer.
Oscar Arrieta, Andrés Felipe Cardona
exaly   +2 more sources

Ubiquitination of CD47 Regulates Innate Anti‐Tumor Immune Response

Advanced Science
In addition to adaptive immune checkpoint of PD‐1/PD‐L1, the innate immune checkpoint SIRPα/CD47 plays an important role in regulation of tumor immune escape. However, the mechanism of CD47 ubiquitination on tumor immune escape remains unclear.
Qian Gou, Bingjun Yan, Yalan Duan, Yilei Guo, Jing Qian, Juanjuan Shi, Yongzhong Hou   +6 more
doaj   +2 more sources

Harnessing the innate immune system: a novel bispecific antibody targeting CD47 and CD24 for selective tumor clearance [PDF]

Journal for ImmunoTherapy of Cancer
Background Tumor-associated macrophages (TAMs) abundantly infiltrate tumors and possess potent antitumor capabilities. “Don‘t eat me” signals like CD47 allow tumors to evade macrophages and proliferate unchecked.
Chao Wang, Juan Zhang, Yi Luo, Yifei Wang, Weifeng Huang, Shaogang Peng, Andy Tsun, Xiaoniu Miao, Liandi Chen, Lidi Nan, Huayuan Liao, Ziyue Cui, Yanqing Lv, Xiaomu Wang   +13 more
doaj   +2 more sources

CD47 expression in solid tumors correlates with phagocytic tumor-associated macrophage gene signature [PDF]

Frontiers in Immunology
BackgroundCD47 is a “don’t eat me” signal that is overexpressed in tumors to evade phagocytosis by tumor associated macrophages (TAM). Investigational agents targeting CD47, such as magrolimab, aim to induce phagocytosis of tumor cells by TAMs ...
Nicholas van Buuren, Nicholas van Buuren, Mengshu Xu, Mengshu Xu, Yi Zhang, Paola Correa, Shiva Zaboli, Azadeh Madjidi, Christina Moon, Szu-Wen Liu, Ruidong Li, Kai-Hui Sun, Shahed Iqbal, Abhishek Aggarwal, Min Wang, Li Li, Jared M. Odegard, Jared M. Odegard, Kelli Boyd   +18 more
doaj   +2 more sources

CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

eLife, 2022
Transgenic CD47 overexpression is an encouraging approach to ameliorating xenograft rejection and alloresponses to pluripotent stem cells, and the efficacy correlates with the level of CD47 expression. However, CD47, upon ligation, also transmits signals
Yang Li, Yan Wu, Elena A Federzoni, Xiaodan Wang, Andre Dharmawan, Xiaoyi Hu, Hui Wang, Robert J Hawley, Sean Stevens, Megan Sykes, Yong-Guang Yang   +10 more
doaj   +1 more source

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis

Molecular Therapy: Oncolytics, 2022
Tumor cells can evade attack by phagocytes by upregulating the self-marker CD47. The mechanisms underlying tumor CD47 upregulation, however, remain unclear.
Shuang Qu, Zichen Jiao, Geng Lu, Jiahan Xu, Bing Yao, Ting Wang, Jun Wang, Yongzhong Yao, Xin Yan, Tao Wang, Hongwei Liang, Ke Zen   +11 more
doaj   +1 more source