Results 1 to 10 of about 24,396 (218)
Advanced Science, 2023 Tumor cells often overexpress immune checkpoint proteins, including CD47, for immune evasion. However, whether or how oncogenic activation of receptor tyrosine kinases, which are crucial drivers in tumor development, regulates CD47 expression is unknown.
Zhimin Lu
exaly +2 more sources
Arteriosclerosis, Thrombosis, and Vascular Biology, 2008 CD47, originally named integrin-associated protein, is a receptor for thrombospondin-1. A number of important roles for CD47 have been defined in regulating the migration, proliferation, and survival of vascular cells, and in regulation of innate and adaptive immunity.
David D Roberts +2 more
exaly +4 more sources
Cancer Medicine, 2020 Objective CD47 is an antiphagocytic molecule that contributes to tumor cell resistance in host immune surveillance. CD47 overexpression correlated with tumor progression and shorter survival in lung cancer.
OSCAR Arrieta +2 more
exaly +2 more sources
CD47 is highly expressed in gliomas and targeting CD47 is a promising therapeutic strategy [PDF]
European Journal of Inflammation, 2021 Gliomas are very malignant brain tumors that are difficult to treat. CD47 is an antiphagocytic molecule that binds to SIPRα on phagocytes. It is overexpressed on the plasma membranes of multiple human tumor cell types and is an important diagnostic and ...
Jiaying Yang +5 more
doaj +2 more sources
Analysis of Prognostic Significance of CD47 Expression in Newly Diagnosed Large B Cell Lymphoma [PDF]
LifeCD47 is a transmembrane protein that possesses the ability to inhibit macrophage phagocytosis, enabling immune system evasion. While CD47 overexpression is associated with a poor prognosis in solid malignancies, data on its prognostic significance in ...
Olivera Markovic +8 more
doaj +2 more sources
Regulation of CD47 expression in cancer cells
Translational Oncology, 2020 CD47 is overexpressed in various types of cancers and it can directly bind with SIRPα, which is mainly located on macrophages. The binding of CD47-SIRPα transmits a “don't eat me” signal, which can prevent cancer cells from immune clearance.
Jinjian Lu, Mu-Yang Huang, Zi-Han Ye
exaly +3 more sources
eLife, 2022 Transgenic CD47 overexpression is an encouraging approach to ameliorating xenograft rejection and alloresponses to pluripotent stem cells, and the efficacy correlates with the level of CD47 expression. However, CD47, upon ligation, also transmits signals
Yang Li +10 more
doaj +1 more source
Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis
Molecular Therapy: Oncolytics, 2022 Tumor cells can evade attack by phagocytes by upregulating the self-marker CD47. The mechanisms underlying tumor CD47 upregulation, however, remain unclear.
Shuang Qu +11 more
doaj +1 more source
CD47 Potentiates Inflammatory Response in Systemic Lupus Erythematosus
Cells, 2021 Background: To investigate the role of CD47 in inflammatory responses in systemic lupus erythematosus (SLE). Methods: Expression of CD47 and signal regulatory protein alpha (SIRPα) by peripheral blood mononuclear cells (PBMCs) and changes in CD47 ...
Jin Kyun Park +4 more
doaj +1 more source
CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications
Diagnostics, 2022 CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma
Seongsik Bang +8 more
doaj +1 more source