Results 31 to 40 of about 42,056 (305)
Cancer Therapy Targeting CD47/SIRPα [PDF]
Cancers, 2021 In the past decade, the field of cancer immunotherapy has rapidly advanced, establishing a crucial role for immune checkpoint blockers in the treatment of a variety of cancer types. In parallel with these remarkable clinical developments, further efforts have focused on ways of unleashing adaptive immune responses against cancer.
Nazli Dizman, Elizabeth I. Buchbinder
openaire +2 more sources
BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton [PDF]
, 2014 BNIP3 is an atypical BH3-only member of the BCL-2 family of proteins with reported pro-death as well as pro-autophagic and cytoprotective functions, depending on the type of stress and cellular context.
Agostinis, P +8 more
core +2 more sources
An overview about erythrocyte membrane [PDF]
, 2010 © 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
core +1 more source
On the mechanism of CD47 targeting in cancer [PDF]
Proceedings of the National Academy of Sciences, 2012 The report by Willingham et al. (1) is the most recent in a series of publications from the same group, in which the interaction between the broadly expressed surface molecule CD47 and the myeloid inhibitory receptor SIRPα was implicated as a potential therapeutic target in a variety of malignancies. The authors used xenotransplantation models in which
Zhao, Xi Wen +3 more
openaire +5 more sources
Frontiers in Oncology, 2019 Knockdown or gene disruption of the ubiquitously expressed cell surface receptor CD47 protects non-malignant cells from genotoxic stress caused by ionizing radiation or cytotoxic chemotherapy but sensitizes tumors in an immune competent host to genotoxic
Sukhbir Kaur +13 more
doaj +1 more source
Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion
Nature Communications, 2022 Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25% one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial fatty acid oxidation (FAO) enzymes (CPT1A, CPT2 and ACAD9) and immune checkpoint
Nian Jiang +28 more
semanticscholar +1 more source
Frontiers in Drug Discovery, 2023 Cell surface molecules PD-L1 and CD47 are potent inhibitors of adaptive and innate anti-cancer immunity. We sought to generate a safe, therapeutic, bispecific antibody specifically targeting, and blocking both PD-L1 and CD47 inhibitory activity.
Irene Tang +16 more
doaj +1 more source
Possible Implication of Red Blood Cells in the Prothrombotic Risk in Early Rheumatoid Arthritis [PDF]
, 2015 Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that can be considered as a prothrombotic state1. A great number of studies have investigated the possible role of reactive oxygen species (ROS) in the etiology and pathogenesis of this ...
DI FRANCO, Manuela +5 more
core +1 more source
The application of HER2 and CD47 CAR-macrophage in ovarian cancer
Journal of Translational Medicine, 2023 Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosuppressive tumor microenvironment ...
Yizhao Chen +17 more
semanticscholar +1 more source
The convergence of radiation and immunogenic cell death signaling pathways. [PDF]
, 2012 Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H +4 more
core +2 more sources