Results 31 to 40 of about 29,411 (265)
Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas
OncoImmunology, 2020 Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages.
Amanda R. Dancsok +8 more
doaj +1 more source
Regulation of CD47 expression on CD14+ monocytes by interferon-α in PBC patients
Frontiers in Immunology, 2023 BackgroundPrimary biliary cholangitis (PBC) is a chronic intrahepatic cholestatic autoimmune liver disease characterized by inflammatory injury of small and medium-sized bile ducts in the liver.
Xi Su +8 more
doaj +1 more source
Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRP alpha axis [PDF]
, 2021 Cancer cells exploit CD47 overexpression to inhibit phagocytic elimination and neoantigen processing via the myeloid CD47-SIRP alpha axis and thereby indirectly evade adaptive T cell immunity.
Helfrich, Wijnand +9 more
core +2 more sources
Animal Cells and Systems, 2020 CD47 is a tumor-associated antigen best known for its ability to bind counter-receptors on the surface of professional phagocytes as an immune-evasion strategy.
Pascal Leclair, Chinten James Lim
doaj +1 more source
OncoImmunology, 2020 Recurrence of advanced epithelial ovarian cancer is common despite optimal surgical debulking and initial favorable responses to chemotherapy. Evidences suggest that cancer stem cells (CSCs) have inherent resistance to conventional therapies such as ...
Chih-Long Chang +3 more
doaj +1 more source
The CD47-SIRPα Immune Checkpoint
Immunity, 2020 The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein, expressed on both healthy and cancer cells, plays a pivotal role in this balance by delivering a "don't eat me signal" upon binding to the Signal-regulatory ...
Meike E.W. Logtenberg +2 more
openaire +3 more sources
On the mechanism of CD47 targeting in cancer [PDF]
Proceedings of the National Academy of Sciences, 2012 The report by Willingham et al. (1) is the most recent in a series of publications from the same group, in which the interaction between the broadly expressed surface molecule CD47 and the myeloid inhibitory receptor SIRPα was implicated as a potential therapeutic target in a variety of malignancies. The authors used xenotransplantation models in which
Zhao, Xi Wen +3 more
openaire +5 more sources
Figure 2A: High CD47 expression, evidenced by diffuse and intense membranous staining in epidermal and dermal tumor cells on immunohistochemistry.
guner, rukiye
core +3 more sources
Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice
OncoImmunology, 2022 CD47 has established roles in the immune system for regulating macrophage phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory roles in natural killer and CD8+ T cells.
Pulak R. Nath +6 more
doaj +1 more source
, 2020 Dysregulated neutrophil (PMN) transmigration across epithelial surfaces (TEpM) significantly contributes to chronic inflammatory diseases, yet mechanisms defining this process remain poorly understood.
Luissint, Anny-Claude +9 more
core +1 more source