Results 51 to 60 of about 42,056 (305)

SIRP/CD47 signaling in neurological disorders [PDF]

Brain Research, 2015
Microglia play important roles in the process of neuronal injury and recovery. Numeous surface receptors have been described to regulate microglial activation. These receptors tightly mediate normal microglial functions including cell mobility, phagocytosis, and production of inflammatory mediators or trophic factors.
Haiyue, Zhang, Fengwu, Li, Yuanyuan, Yang, Jun, Chen, Xiaoming, Hu   +4 more
openaire   +2 more sources

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions [PDF]

, 2013
CD47 plays an important but incompletely understood role in the innate and adaptive immune responses. CD47, also called integrin-associated protein, has been demonstrated to associate in cis with β1 and β3 integrins. Here we test the hypothesis that CD47
Alcaide P, Andrew D, Andrè Manica, Angela B. Schmider, Azcutia V, Barclay AN, Brittain JE, Brown E, Brown EJ, Charles A. Parkos, Chen C, Constantin G, Cooper D, de Vries HE, Dransfield I, Fortin G, Francis W. Luscinskas, Gail Newton, Han MH, Hogg N, Isenberg JS, Kevin J. Croce, Kim M, Lefort CT, Ley K, Lim YC, Lindberg FP, Luque A, Mandal AK, Marcie R. Williams, Mark H. Ginsberg, Matthew Routledge, McDonald JF, Melissa V. Turman, Miller LJ, Parkos CA, Quinn MT, Roy J. Soberman, Salas A, Shamri R, Shimaoka M, Sircar M, Smith A, Snapp KR, Stefanidakis M, Su X, Ticchioni M, Veronica Azcutia, William A. Frazier, Yang J   +49 more
core   +2 more sources

Engineered CD47 protects T cells for enhanced antitumour immunity

Nature
Adoptively transferred T cells and agents designed to block the CD47–SIRPα axis are promising cancer therapeutics that activate distinct arms of the immune system1,2.
Sean A. Yamada-Hunter, J. Theruvath, Brianna J. McIntosh, Katherine A Freitas, Frank Lin, Molly Radosevich, A. Leruste, Shaurya Dhingra, Naiara Martinez-Velez, Peng Xu, Jing Huang, A. Delaidelli, Moksha H Desai, Zinaida Good, Roel Polak, Audre May, Louai Labanieh, J. Bjelajac, Tara Murty, Zachary J Ehlinger, Christopher W. Mount, Yiyun Chen, S. Heitzeneder, Kristopher D Marjon, A. Banuelos, Omair Khan, Savannah L. Wasserman, J. Spiegel, S. Fernandez-Pol, Calvin J. Kuo, P. Sorensen, Michelle Monje, R. Majzner, Irving L. Weissman, B. Sahaf, E. Sotillo, Jennifer R. Cochran, Crystal L. Mackall   +37 more
semanticscholar   +1 more source

Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas

OncoImmunology, 2020
Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages.
Amanda R. Dancsok, Dongxia Gao, Anna F. Lee, Sonja Eriksson Steigen, Jean-Yves Blay, David M. Thomas, Robert G. Maki, Torsten O. Nielsen, Elizabeth G. Demicco   +8 more
doaj   +1 more source

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman, Erik Hrabovszky, Imre Kalló, István Likó, Miklós Sárvári, Nicole Berchtold, Norbert Solymosi, Sárvári, Miklós, Zsolt Liposits   +8 more
core   +2 more sources

Rapid Dendritic Cell Activation and Resistance to Allotolerance Induction in Anti-CD154-Treated Mice Receiving CD47-Deficient Donor-Specific Transfusion

Cell Transplantation, 2014
CD47–SIRPα signaling plays an important role in regulating macrophage and dendritic cell (DC) activation. Here we investigated the role of CD47 expression on donor cells in tolerance induction by combined treatment with donor-specific transfusion (DST ...
Yuantao Wang, Hui Wang, Roderick Bronson, Yaowen Fu M.D., Ph.D., Yong-Guang Yang M.D., Ph.D.   +4 more
doaj   +1 more source

An in-situ peptide-antibody self-assembly to block CD47 and CD24 signaling enhances macrophage-mediated phagocytosis and anti-tumor immune responses

Nature Communications
Targeted immunomodulation for reactivating innate cells, especially macrophages, holds great promise to complement current adaptive immunotherapy. Nevertheless, there is still a lack of high-performance therapeutics for blocking macrophage phagocytosis ...
Weiqi Zhang, Yinghua Zeng, Qiuqun Xiao, Yuanyuan Wu, Jiale Liu, Haocheng Wang, Yuting Luo, Jie Zhan, Ning Liao, Yanbin Cai   +9 more
semanticscholar   +1 more source

Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy

Oncology Research, 2023
Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein, has been identified as a crucial regulator
Qiuqiang Chen, Xuejun Guo, Wenxue Ma
semanticscholar   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

CD47 Expression in Natural Killer Cells Regulates Homeostasis and Modulates Immune Response to Lymphocytic Choriomeningitis Virus

Frontiers in Immunology, 2018
CD47 is a ubiquitous cell surface receptor that directly regulates T cell immunity by interacting with its inhibitory ligand thrombospondin-1 and limits clearance of cells by phagocytes that express its counter-receptor signal-regulatory protein-α ...
Pulak Ranjan Nath, Arunakumar Gangaplara, Dipasmita Pal-Nath, Ajeet Mandal, Dragan Maric, John M. Sipes, Maggie Cam, Ethan M. Shevach, David D. Roberts   +8 more
doaj   +1 more source