Results 61 to 70 of about 29,411 (265)

CD47 Expression in Natural Killer Cells Regulates Homeostasis and Modulates Immune Response to Lymphocytic Choriomeningitis Virus

Frontiers in Immunology, 2018
CD47 is a ubiquitous cell surface receptor that directly regulates T cell immunity by interacting with its inhibitory ligand thrombospondin-1 and limits clearance of cells by phagocytes that express its counter-receptor signal-regulatory protein-α ...
Pulak Ranjan Nath, Arunakumar Gangaplara, Dipasmita Pal-Nath, Ajeet Mandal, Dragan Maric, John M. Sipes, Maggie Cam, Ethan M. Shevach, David D. Roberts   +8 more
doaj   +1 more source

CD47 Regulates Parasite Burden and Promotes Pathogenesis in Murine Malaria Models

, 2021
CD47 is an anti-phagocytic (don’t eat me) signal that inhibits programmed cell removal of self and loss of this molecule by aging erythrocytes is associated with increased susceptibility to clearance by macrophages.
Kumar, Sanjai, Malla, Pallavi, Majam, Victoria, Okoth, Winter A, Weissman, Irving L, Chorazeczewski, Joanna K, Meredith, Scott, Dulgeroff, Laughing Bear Torrez, Rotstein, David S, Oakley, Miranda S   +9 more
core  

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Ubiquitination of CD47 Regulates Innate Anti‐Tumor Immune Response

Advanced Science
In addition to adaptive immune checkpoint of PD‐1/PD‐L1, the innate immune checkpoint SIRPα/CD47 plays an important role in regulation of tumor immune escape. However, the mechanism of CD47 ubiquitination on tumor immune escape remains unclear.
Qian Gou, Bingjun Yan, Yalan Duan, Yilei Guo, Jing Qian, Juanjuan Shi, Yongzhong Hou   +6 more
doaj   +1 more source

Effect and mechanism of targeted delivery of VEGF and CD47 dual-modifiedexosomes in treatment of acute kidney injury induced by heat stroke in rats in the desert dry hot environment.

陆军军医大学学报
Objective To develop an effective method for delivering VEGF and CD47 double-modified exosomes to treat renal damage induced by heat stroke so as to reduce and repair renal damage.
HAN Xiaobo, DENG Xinkai, LI Hong
doaj   +1 more source

Targeting CD47-SIRPa axis shows potent preclinical anti-tumor activity as monotherapy and synergizes with PARP inhibition

npj Precision Oncology, 2023
The objective was to correlate CD47 gene expression with resistance to immune checkpoint inhibitors (ICI) in tumor tissue of gynecological cancer (GC).
Hussein Al-Sudani, Ying Ni, Philip Jones, Huseyin Karakilic, Lei Cui, Lisa D. S. Johnson, Peter G. Rose, Alexander Olawaiye, Robert P. Edwards, Robert A. Uger, Gloria H. Y. Lin, Haider Mahdi   +11 more
doaj   +1 more source

CD47 Augments Fas/CD95-mediated Apoptosis

, 2005
Fas (CD95) mediates apoptosis of many cell types, but the susceptibility of cells to killing by Fas ligand and anti-Fas antibodies is highly variable.
Partha P. Manna, Per-Arne Oldenborg, Frazier, William A, Julie Dimitry, Dimitry, Julie, Oldenborg, Per-Arne,, Manna, Partha P, William A. Frazier   +7 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources