Results 81 to 90 of about 42,056 (305)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

MGMT unmethylation and high levels of CD47 and TIGIT indicate a poor prognosis in adult diffuse gliomas

Frontiers in Immunology
IntroductionIn 2021, the World Health Organization published a new classification system for central nervous system tumors. This study reclassified the adult diffuse glioma (ADG) into astrocytoma, oligodendroglioma, and glioblastoma (GBM) according to ...
Lingbo Ma, Yi Shi, Chang Li, Bin Deng, Jinfang Jiang, Yuwen Cao, Lianghai Wang, Hongyan Li   +7 more
doaj   +1 more source

La fusion des macrophages : partenaires des cellules somatiques et cancéreuses ? [PDF]

, 2005
La fusion est un mécanisme fondamental utilisé par les organismes multicellulaires. Elle joue un rôle essentiel au cours du développement physiologique.
Vignery, Agnès
core   +1 more source

Opportunities and challenges for anti-CD47 antibodies in hematological malignancies

Frontiers in Immunology
CD47 is a cell-surface ligand that is overexpressed in various malignancies and that binds to SIRPα on macrophages to promote tumor cell evasion of phagocytosis. Blocking the CD47-SIRPα axis can increase the phagocytosis of macrophages to exert antitumor
Yilan Xu, Panruo Jiang, Zhenyan Xu, Haige Ye   +3 more
semanticscholar   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Analysis of meteorological data from RRS Charles Darwin cruises CD46 and CD47 (BOFS experiment) [PDF]

, 1993
The IOSDL MultiMet meteorological instrumentation system was used during the BOFS experiment on RRS Charles Darwin cruises 46 and 47. This report describes and evaluates the quality of the meteorological data obtained.
Birch, K.G., Pascal, R.W., Taylor, P.K., Tiddy, R.J.   +3 more
core  

Exosomes: Versatile Nano Mediators of Immune Regulation. [PDF]

, 2019
One of many types of extracellular vesicles (EVs), exosomes are nanovesicle structures that are released by almost all living cells that can perform a wide range of critical biological functions.
Cacalano, Nicholas A, Huyan, Ting, Li, Qi, Peng, Hourong, Wang, Helei   +4 more
core   +1 more source

Immune targets in the tumor microenvironment treated by radiotherapy. [PDF]

, 2019
Radiotherapy (RT), the major anti-cancer modality for more than half of cancer patients after diagnosis, has the advantage of local tumor control with relatively less systematic side effects comparing to chemotherapy.
Li, Jian Jian, Ozpiskin, Omer M, Zhang, Lu   +2 more
core  

Metabolic reprograming mediated by tumor cell-intrinsic type I IFN signaling is required for CD47-SIRPα blockade efficacy

Nature Communications
Type I interferons have been well recognized for their roles in various types of immune cells during tumor immunotherapy. However, their direct effects on tumor cells are less understood.
Hang Zhou, Wenjun Wang, Hairong Xu, Yong Liang, Jiyu Ding, Mengjie Lv, Boyang Ren, Hua Peng, Yangbo Fu, Mingzhao Zhu   +9 more
semanticscholar   +1 more source