Results 81 to 90 of about 24,396 (218)

Tuning the radio with CD47 [PDF]

Science-Business eXchange, 2009
NCI researchers think they have found a strategy that not only protects healthy tissue during radiation treatment but also enhances antitumor response, most likely by protecting tumor-infiltrating immune cells.
openaire   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Human CD47 Expression Permits Survival of Porcine Cells in Immunodeficient Mice that Express SIRPα Capable of Binding to Human CD47

Cell Transplantation, 2011
Signal regulatory protein α (SIRPα) is a critical immune inhibitory receptor on macrophages, and its interaction with CD47 prevents autologous phagocytosis.
Chunfeng Wang, Hui Wang, Kentaro Ide, Yuantao Wang, Nico Van Rooijen, Hideki Ohdan, Yong-Guang Yang M.D., Ph.D.   +6 more
doaj   +1 more source

Multivalent Bi‐Specific Nanoerythrosomes: A Two‐Birds‐One‐Stone Approach to Combine Homologous and Active Targeting for Effective Thrombolysis

Small, EarlyView.
A multivalent bi‐specific nanoerythrosome (mBiNE@tPA) is developed as a “two‐birds‐one‐stone” platform that simultaneously exploits two principal thrombus components. By integrating erythrocyte membrane‐mediated homologous targeting with cRGD‐based active targeting to activated platelets, mBiNE@tPA achieves enhanced thrombus accumulation, triggered ...
Yu Huang, Yilin Yang, Nicole Henry, Boram Gu, Jiahua Wang, Yuanyuan Guo, Colin Longstaff, Simon A. Thom, Yuehua Li, Xiao Yun Xu, Rongjun Chen   +10 more
wiley   +1 more source

Targeting CD47-mediated cancer senescence, a novel strategy for cancer immunotherapy

Frontiers in Immunology
A transmembrane protein that is extensively expressed, CD47 has an important role in the senescence of cancer cells. Therapy-induced senescence (TIS) by chemotherapy and radiotherapy restrains tumor proliferation yet drives immune evasion and treatment ...
Bei Zhao, Chunlu Liao, Hailian Wang, Hailian Wang, Mingyi Chen, Jianing Yang   +5 more
doaj   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, EarlyView.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

CD47 [PDF]

Science-Business eXchange, 2009
openaire   +2 more sources

Shear‐Responsive Red Blood Cell Carriers for Targeted Drug Delivery to Constricted Arteries

Small, EarlyView.
Red blood cells are harnessed as mechanoresponsive carriers that exploit the elevated shear stress of stenotic arteries to transiently open membrane pores and release encapsulated therapeutics selectively at sites of arterial narrowing. By coupling vascular hemodynamics with RBC membrane mechanics, a hemodynamically activated platform for localized ...
Danielle Nemcovsky Amar, Rukiye Tuna, Tirosh Mekler, Merav Belenkovich, Dmitry Korneyev, Yevgeniy Kreinin, Anat Glozman, Josué Sznitman, Donald E. Ingber, Zixiang Leonardo Liu, Netanel Korin   +10 more
wiley   +1 more source

Harnessing the innate immune system: a novel bispecific antibody targeting CD47 and CD24 for selective tumor clearance

Journal for ImmunoTherapy of Cancer
Background Tumor-associated macrophages (TAMs) abundantly infiltrate tumors and possess potent antitumor capabilities. “Don‘t eat me” signals like CD47 allow tumors to evade macrophages and proliferate unchecked.
Chao Wang, Juan Zhang, Yi Luo, Yifei Wang, Weifeng Huang, Shaogang Peng, Andy Tsun, Xiaoniu Miao, Liandi Chen, Lidi Nan, Huayuan Liao, Ziyue Cui, Yanqing Lv, Xiaomu Wang   +13 more
doaj   +1 more source

Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma

Cancer Medicine, 2019
Background Treatments based on the inhibition of pivotal signals of cancer stem cells (CSCs) are on a promising track. Recent studies have shown that targeting CSCs with broader immune‐based therapeutic methods, for example, the anti‐CD47 treatment, may ...
Jian‐Hua Wang, Shu‐Ting Huang, Lan Zhang, Zi‐Gang Liu, Rong‐Xin Liang, Sen‐Wei Jiang, Yi‐Nan Jiang, Xing‐Juan Yu, Yu‐Chuan Jiang, Xi‐Zhao Li, Pei‐Fen Zhang, Zhe‐Sheng Wen, Min Zheng   +12 more
doaj   +1 more source