Results 101 to 110 of about 42,056 (305)

Biomimetic Nano‐Degrader Based CD47‐SIRPα Immune Checkpoint Inhibition Promotes Macrophage Efferocytosis for Cardiac Repair

Advancement of science
CD47‐SIRPα axis is an immunotherapeutic target in tumor therapy. However, current monoclonal antibody targeting CD47‐SIRPα axis is associated with on‐target off‐tumor and antigen sink effects, which significantly limit its potential clinical application.
Jinfeng Gao, Zhiqing Pang, Qiaozi Wang, Yiwen Tan, Qiyu Li, Haipeng Tan, Jing Chen, Wusiman Yakufu, Zhengmin Wang, Hongbo Yang, Jinyan Zhang, Dili Sun, Xueyi Weng, Qibing Wang, Juying Qian, Yanan Song, Zheyong Huang, Junbo Ge   +17 more
semanticscholar   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Of macrophages and red blood cells; a complex love story [PDF]

, 2014
Macrophages tightly control the production and clearance of red blood cells (RBC). During steady state hematopoiesis, approximately 10(10) RBC are produced per hour within erythroblastic islands in humans.
Djuna Z. de Back, Elena B. Kostova, Marian van Kraaij, Robin van Bruggen, Timo K. van den Berg   +4 more
core   +2 more sources

Hypoxia-induced ZEB1 promotes cervical cancer immune evasion by strengthening the CD47-SIRPα axis

Cell Communication and Signaling
Background The dynamic interaction between cancer cells and tumour-associated macrophages (TAMs) in the hypoxic tumour microenvironment (TME) is an active barrier to the effector arm of the antitumour immune response.
Xiaojing Chen, Chu-Hong Guo, Zici Wang, Yang Yang, Yu-Hua Pan, Jie Liang, Meiyang Sun, Liang Fan, L. Liang, Wei Wang   +9 more
semanticscholar   +1 more source

CD47-Blocking Antibodies and Atherosclerosis

JACC: Basic to Translational Science, 2016
Phagocytosis is a well understood process whereby pathogens and cell debris are removed from within the body, and it is an important homeostatic mechanism in health and disease. What is less commonly discussed is the process of “efferocytosis.” This term, derived from the Latin prefix effero- ,
openaire   +3 more sources

Targeting CD47 in Sézary syndrome with SIRPαFc

Blood Advances, 2019
AbstractSézary syndrome (SS), the leukemic variant of cutaneous T-cell lymphoma, has limited treatment options and rare occurrences of long-term remission, thus warranting research into new treatment approaches. CD47 has emerged as a promising target for multiple tumor types, but its role in SS remains unknown.
Lisa D. S. Johnson, Swati Banerjee, Oleg Kruglov, Natasja Nielsen Viller, Steven M. Horwitz, Alexander Lesokhin, Jasmine Zain, Christiane Querfeld, Robert Chen, Craig Okada, Ahmed Sawas, Owen A. O’Connor, Eric L. Sievers, Yaping Shou, Robert A. Uger, Mark Wong, Oleg E. Akilov   +16 more
openaire   +2 more sources

The effects of obesity on CD47 expression in erythrocytes [PDF]

Cytometry Part B: Clinical Cytometry, 2015
BackgroundTo investigate the effects of obesity on CD47, phosphatidylserine (PS) exposure, and Caspase‐8 and Caspase‐3 activities in erythrocytes.MethodsThe study included 25 morbidly obese patients and 20 healthy people as the control group. We evaluated CD47 expression on the red blood cell (RBC) membrane surface and eryptosis markers such as PS ...
Maciej, Wiewiora, Jerzy, Piecuch, Lukasz, Sedek, Bogdan, Mazur, Krystyn, Sosada   +4 more
openaire   +2 more sources

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Ibrutinib impairs the phagocytosis of rituximab-coated leukemic cells from chronic lymphocytic leukemia patients by human macrophages [PDF]

, 2015
We have read with great interest the recent article of Kohrt, H.E. et al1 showing that Ibrutinib prevented NK cell mediated cytotoxicity of antibody-coated CLL cells in vitro.
Almejún, María Belén, Bezares, Raimundo F., Borge, Mercedes, Cabrejo, María, Colado, Ana, Fernández Grecco, Horacio, Gamberale, Romina, Giordano, Mirta Nilda, Podaza, Enrique Arturo   +8 more
core   +2 more sources

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source