Results 121 to 130 of about 29,411 (265)

Is CD47 an innate immune checkpoint for tumor evasion?

, 2017
Cluster of differentiation 47 (CD47) (also known as integrin-associated protein) is a ubiquitously expressed glycoprotein of the immunoglobulin superfamily that plays a critical role in self-recognition. Various solid and hematologic cancers exploit CD47
Yang-xin Fu, Fu, Yang-xin, Xiaojuan Liu, Kwon, Hyunwoo, Hyunwoo Kwon, Zihai Li, Liu, Xiaojuan, Li, Zihai   +7 more
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Phase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein SL-172154 (SIRPα-Fc-CD40L) in patients with higher-risk myelodysplastic syndrome or acute myeloid leukemia. [PDF]

Cancer
Abstract Background This clinical trial sought to determine whether SL‐172154 could be combined safely and improve the efficacy of azacitidine (AZA) in patients with higher‐risk myelodysplastic syndrome (HR‐MDS) or acute myeloid leukemia (AML). Methods Dose escalation: doses of 1, 3, and 6 mg/kg SL‐172154 was evaluated as monotherapy or in combination ...
Daver NG, Zeidan AM, Stein AS, Zeidner JF, Maher K, Curran E, Bixby D, Chai-Ho W, Stahl M, Yee KWL, Stevens D, Ito S, Reynolds J, Medd P, Searle E, Sochacki A, Savoie ML, Green S, Kato K, Hernandez R, Metenou S, Ma B, Pandite L, Schreiber TH, Sallman DA.   +24 more
europepmc   +2 more sources

Biomimetic PB@PDA‐CA@Mem nanoplatform regulates oxidative stress and inflammatory microenvironment to enhance stroke recovery

VIEW, EarlyView.
PB@PDA‐CA@Mem enhances ischemic brain accumulation and enables acid‐responsive CA release. Through broad‐spectrum ROS/RNS scavenging, Nrf2/Keap1 activation, and NF‐κB/NLRP3 suppression, it alleviates oxidative stress and neuroinflammation, preserves neuronal architecture, reduces infarction, and improves functional recovery.
Lei Shi, Zhuonan Wang, Chenxi Zhou, Shuping Wang, Xuting Shen, Si Cheng, Yongli Yang, Nengrui Guo, Zhengrong Zhong, Lijun Bai   +9 more
wiley   +1 more source

CD47-blocking antibody confers metabolic benefits against obesity

Cell Reports Medicine
Summary: CD47-blocking antibody is a well-known potential antibody drug for tumor immunotherapy. However, it is unclear whether CD47-blocking antibody can protect against metabolic disorders.
Yajuan Su, Jingyu Sun, Xiaobo Li, Feier Huang, Yunhui Kong, Zian Chen, Jingzhi Zhang, Duran Qin, Xiangyi Chen, Zhaoyue Wang, Yu Pei, Mengting Gong, Kaijiang Yang, Minglu Xu, Yu Dong, Qing He, Zhen-Ning Zhang, Zhejin Sheng, Qiaolin Deng, Hong Wang, Gaowei Wang, Ping Hu, Rongrong Le, Shaorong Gao, Weida Li   +24 more
doaj   +1 more source

Attenuation of phagocytosis of xenogeneic cells by manipulating CD47

, 2007
Signal regulatory protein alpha (SIRPalpha) is a critical immune inhibitory receptor on macrophages, and its interaction with CD47, a ligand for SIRPalpha, prevents autologous phagocytosis.
VerHalen, Jon, Lan, Ping, Sykes, Megan, Oldenborg, Per-Arne,, Wang, Shumei, Wang, Hui, Madariaga, Maria Lucia, Xiang, Shuanglin, Yang, Yong-Guang   +8 more
core   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, EarlyView.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

Xenotransplantation at a Crossroads: Breakthroughs, Challenges, and the Path Forward

Organ Medicine, EarlyView.
Xiaoyu Gan, Jizhang Yu, Jie Wu, Junjie Zong   +3 more
wiley   +1 more source

CD47 promotes myeloma cell growth through JAK–STAT3/MYC signalling and is targetable by ruxolitinib

British Journal of Haematology, EarlyView.
Summary Cluster of differentiation 47 (CD47), a ‘don't eat me’ immune checkpoint receptor, is frequently overexpressed on multiple myeloma (MM) cells and contributes to immune evasion. While its immune regulatory function is well established, the intrinsic oncogenic role of CD47 remains poorly understood.
Omar Faruq, Deepak Iyer, Patrick Wang, Mariusz Shrestha, Cuihong Wei, Aaron D. Schimmer, Hong Chang   +6 more
wiley   +1 more source

Isolation of Recombinant IgV-CD47 Fragment to Probe the Interaction Between CD47 and Mac-1 Integrin

, 2021
: CD47 is a cell surface receptor expressed on many cells in the body. It has many immune functions such as marking host cells as “self†and the activation of apoptosis through phagocytosis.

core