Results 141 to 150 of about 42,056 (305)

CD47 Contributes to the Proliferation of Breast Cancer

Frontiers in Bioscience-Landmark
Background: The CD47 molecule (CD47) performs a novel role in regulating immunoreactions by binding to signal-regulatory protein alpha (SIRPα), resulting in the tumorigenesis of multiple malignant neoplasms. However, its effects and mechanisms in breast cancer (BC) remain unknown.
Ying Xu, Xuejian Liu, Xia Wu, Junbin Wang   +3 more
openaire   +3 more sources

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer [PDF]

, 2016
Background Building up of pathway-/disease-relevant signatures provides a persuasive tool for understanding the functional relevance of gene alterations and gene network associations in multifactorial human diseases.
Birner, Peter, Braicu, Ioana, Castillo-Tong,Dan Cacsire, Hager, Gudrun, Heinze, Georg, Jaritz, Markus, Jensen-Jarolim, Erika, Lambrechts, Sandrina, Mahner, Sven, Mechtcheriakova, Diana, Meshcheryakova, Anastasia, Pils, Dietmar, Sehouli, Jalid, Svoboda, Martin, Thalhammer, Theresia, Vergote, Ignace, Zeillinger, Robert, Zimmermann, Philip   +17 more
core   +2 more sources

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Human CD47 Expression Permits Survival of Porcine Cells in Immunodeficient Mice that Express SIRPα Capable of Binding to Human CD47

Cell Transplantation, 2011
Signal regulatory protein α (SIRPα) is a critical immune inhibitory receptor on macrophages, and its interaction with CD47 prevents autologous phagocytosis.
Chunfeng Wang, Hui Wang, Kentaro Ide, Yuantao Wang, Nico Van Rooijen, Hideki Ohdan, Yong-Guang Yang M.D., Ph.D.   +6 more
doaj   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Co-targeting CD47 and VEGF elicited potent anti-tumor effects in gastric cancer

Cancer Immunology and Immunotherapy
CD47, serving as an intrinsic immune checkpoint, has demonstrated efficacy as an anti-tumor target in hematologic malignancies. Nevertheless, the clinical relevance of CD47 in gastric cancer and its potential as a therapeutic target remains unclear.
Kaiqi Zhang, Yuan Xu, Xusheng Chang, Cailing Xu, Wenjing Xue, Dan Ding, Mingming Nie, Hui Cai, Jun Xu, Lu Zhan, Jiangbo Han, Tiancai Cai, Dianwen Ju, Li Feng, Xuyao Zhang, Kai Yin   +15 more
semanticscholar   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma

Cancer Medicine, 2019
Background Treatments based on the inhibition of pivotal signals of cancer stem cells (CSCs) are on a promising track. Recent studies have shown that targeting CSCs with broader immune‐based therapeutic methods, for example, the anti‐CD47 treatment, may ...
Jian‐Hua Wang, Shu‐Ting Huang, Lan Zhang, Zi‐Gang Liu, Rong‐Xin Liang, Sen‐Wei Jiang, Yi‐Nan Jiang, Xing‐Juan Yu, Yu‐Chuan Jiang, Xi‐Zhao Li, Pei‐Fen Zhang, Zhe‐Sheng Wen, Min Zheng   +12 more
doaj   +1 more source

Airway epithelial CD47 plays a critical role in inducing influenza virus-mediated bacterial super-infection

Nature Communications
Respiratory viral infection increases host susceptibility to secondary bacterial infections, yet the precise dynamics within airway epithelia remain elusive.
Sungmin Moon, Seunghan Han, In-Hwan Jang, Jaechan Ryu, Min-Seok Rha, Hyung-Ju Cho, Sang Sun Yoon, Ki-Taek Nam, Chang-Hoon Kim, Man-Seong Park, J. Seong, Won-Jae Lee, Joo-Heon Yoon, Youn Wook Chung, Ji-Hwan Ryu   +14 more
semanticscholar   +1 more source