Results 131 to 140 of about 42,056 (305)

CD47 [PDF]

Science-Business eXchange, 2012
David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg   +2 more
openaire   +2 more sources

Effect and mechanism of targeted delivery of VEGF and CD47 dual-modifiedexosomes in treatment of acute kidney injury induced by heat stroke in rats in the desert dry hot environment.

陆军军医大学学报
Objective To develop an effective method for delivering VEGF and CD47 double-modified exosomes to treat renal damage induced by heat stroke so as to reduce and repair renal damage.
HAN Xiaobo, DENG Xinkai, LI Hong
doaj   +1 more source

Real‐Time In Vivo Visualization of Tumor‐Associated Macrophage Reprogramming Using a Nitric Oxide‐Activatable NIR‐II Nanoinducer

Advanced Science, EarlyView.
Reprogramming tumor‐associated macrophages is a promising therapeutic strategy for solid tumors. Here, a nitric oxide (NO)‐activatable NIR‐II fluorescence/photoacoustic nanoinducer (I/E@M2pep) that simultaneously facilitates and visualizes the repolarization of TAMs to an M1‐like phenotype is reported, thereby enhancing anti‐tumor efficacy through M1 ...
Qian Chen, Meng Li, Tuanwei Li, Chen Yang, Xiaohu Yang, Hongchao Yang, Yejun Zhang, Chunyan Li, Qiangbin Wang   +8 more
wiley   +1 more source

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]

, 2019
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Aplin, Andrew E., Cui, Yan-Hong, Deng, Yu, He, Chuan, He, Yu-Ying, Hwang, Seungmin, Lu, Zhike, Park, Gayoung, Shah, Palak, Wei, Jiangbo, Yang, Seungwon   +10 more
core   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity. [PDF]

, 2015
Journal ArticleReviewOpen access article originally published in Frontiers in Oncology, 2017, Vol. 5, Article no. 7Endoplasmic reticulum (ER) chaperones (e.g., calreticulin, heat shock proteins, and isomerases) perform a multitude of functions within the
Afshar, Aguilar-Guzman, Alaiya, Altmeyer, Alur, Apetoh, Arispe, Arnaudeau, Basu, Berwin, Bodman-Smith, Cancino, Capitani, Caro, Casciola-Rosen, Castro, Chao, Chao, Chen, Clark, Decca, Dejeans, Denning, Deshaies, Dihazi, Donnelly, Dumitriu, D’Eliseo, Eggleton, Eggleton, Feng, Feng, Feng, Fredly, Freedman, Fucikova, Galazis, Gardai, Garg, Garg, Gaucci, Ghiringhelli, Giannotta, Gidalevitz, Goeb, Gold, Han, Hemminki, Hemminki, Hirai, Holaska, Hong, Jeffery, Kageyama, Kepp, Kepp, Kinoshita, Kishore, Komurasaki, Korbelik, Kosakowska-Cholody, Kreisel, Krieg, Leys, Li, Ling, Ling, Ling, Ling, Liu, Liu, Liu, Lopez, Lopez Sambrooks, Lu, Martins, Matzinger, Mazzarello, Menger, Montero, Morelli, Multhoff, Munro, Nagayama, Nangalia, Ni, Obeid, Obeid, Oyadomari, Paidassi, Palade, Palade, Palade, Pan, Panaretakis, Panaretakis, Panayi, Patel, Peters, Platet, Porter, Pulvirenti, Raiter, Ramirez, Robert, Saha, Sanchez, Sauk, Scaffidi, Schachter, Schwanhausser, Song, Srivastava, Suzuki, Tamura, Tarr, Tarr, Townsley, Tsai, Tufi, Udono, Vandivier, Vannucchi, Wang, Wang, Watanabe, Weber, Wemeau, Wiest, Xu, Xu, Yamamoto, Yokota, Yoon, Zamanian, Zappasodi, Zhang, Zhang, Zhang   +138 more
core   +3 more sources

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Targeting CD47/SIRPα in Acute Myeloid Leukemia and Myelodysplastic Syndrome: Preclinical and Clinical Developments of Magrolimab [PDF]

Journal of Immunotherapy and Precision Oncology, 2021
Fadi Haddad, Naval Daver
doaj   +1 more source

Characterization of the Pathophysiological Role of CD47 in Uveal Melanoma

Molecules, 2019
Uveal melanoma (UM) represents the most frequent primary intraocular tumor, however, limited therapeutic options are still available. We have previously shown that cluster of differentiation 47 (CD47) is significantly upregulated in UM cells following ...
Maria Cristina Petralia, Emanuela Mazzon, Paolo Fagone, Andrea Russo, Antonio Longo, Teresio Avitabile, Ferdinando Nicoletti, Michele Reibaldi, Maria Sofia Basile   +8 more
doaj   +1 more source

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease [PDF]

, 2011
Background Reactive microglia are associated with β-amyloid (Aβ) deposit and clearance in Alzhiemer's Disease (AD). Paradoxically, entocranial resident microglia fail to trigger an effective phagocytic response to clear Aβ deposits although ...
Xiao-dong Pan, Yuan-gui Zhu, Nan Lin, Jing Zhang, Qin-yong Ye, Hua-pin Huang, Xiao-chun Chen   +6 more
core   +1 more source