Results 131 to 140 of about 29,411 (265)
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
C1 iPS cells evade phagocytosis by macrophages through CD47 ligand.
, 2014 (A) Expression of CD47 was evaluated by immunocytochemistry and semi-quantitative PCR (n = 3). C1 iPS cells expressed CD47 to the same extent as fibroblasts.
Yoshihisa Mizukami (406138) +8 more
core +1 more source
British Journal of Pharmacology, EarlyView.Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka +3 more
wiley +1 more source
Targeting CD47 and Angiogenesis Demonstrates Effective Anti-Tumor Effect in Bladder Cancer
BiomedicinesBackground: Although immunotherapy has shown potential in cancer treatment, current immunotherapeutics for bladder cancer are limited by a low response rate.
Xiting Huang +6 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff +3 more
wiley +1 more source
CD47 IS A NOVEL TARGET FOR CANCER IMMUNOTHERAPY TREATMENT
, 2022 Cancer immunotherapies have revolutionized the treatment of cancer; however, only a subset of patient’s respond to these therapeutics. Therefore, predictive biomarkers and therapeutic targets are needed to improve patient response.
Stirling, Elizabeth Rose
core
Cancer Science, EarlyView.Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Hiroshi Ureshino, Shinya Kimura
wiley +1 more source
Translational OncologyObjectives: Alpha fetoprotein(AFP) overexpression connecting with macrophage dysfunction remain poorly defined. In this study, explore AFP regulates macrophage immunomodulation in hepatocellular carcinoma(HCC) through comprehensive in vitro and in vivo ...
Yinglian Pan +11 more
doaj +1 more source
Prognostic importance of CD47 expression on survival of colorectal cancer
Background The exact value of cluster of differentiation 47 (CD47), known as the "don't eat me"signal, in colorectal cancer (CRC) has not been clearly revealed.
Yildirim, Eda Caliskan +10 more
core +1 more source
Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy [PDF]
Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein, has been identified as a crucial regulator
GUO, XUEJUN, MA, WENXUE, CHEN, QIUQIANG
core +1 more source