Results 111 to 120 of about 42,056 (305)

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas. [PDF]

, 2019
PurposeGlioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for ...
Kaprealian, Tania, Lee, Mi-Heon, McBride, William H, Nesseler, Jean Philippe, Nickers, Philippe, Niclou, Simone P, Schaue, Dorthe   +6 more
core  

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]

, 2018
Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S., Beattie, Lynette, Hoehme, Stefan, Kaye, Paul M., Moore, John W. J., Moyo, Daniel, Sampson, Adam T., Sawtell, Amy, Timmis, Jon   +8 more
core   +5 more sources

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer [PDF]

Nature Communications, 2017
AbstractCD47 is a cell surface molecule that inhibits phagocytosis of cells that express it by binding to its receptor, SIRPα, on macrophages and other immune cells. CD47 is expressed at different levels by neoplastic and normal cells. Here, to reveal mechanisms by which different neoplastic cells generate this dominant ‘don’t eat me’ signal, we ...
Paola A. Betancur, Brian J. Abraham, Ying Y. Yiu, Stephen B. Willingham, Farnaz Khameneh, Mark Zarnegar, Angera H. Kuo, Kelly McKenna, Yoko Kojima, Nicholas J. Leeper, Po Ho, Phung Gip, Tomek Swigut, Richard I. Sherwood, Michael F. Clarke, George Somlo, Richard A. Young, Irving L. Weissman   +17 more
openaire   +5 more sources

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. [PDF]

, 2017
Senescent cells withdraw from the cell cycle and do not proliferate. The prevalence of senescent compared to normally functioning parenchymal cells increases with age, impairing tissue and organ homeostasis. A contentious principle governing this process
Al Ghouleh, I, Amaral, JH, Attaran, S, Bienes-Martinez, R, Cifuentes-Pagano, E, Gladwin, MT, Isenberg, JS, Knupp, HE, Meijles, DN, Nouraie, SM, Novelli, EM, Pagano, PJ, Rojas, MM, Sahoo, S, Sembrat, JC   +14 more
core   +1 more source

Significance of CD47 expression in gastric cancer

Oncology Letters, 2017
Integrin-associated protein (CD47) is ubiquitously expressed on the surface of cells and functions as an identifier of self. In blood cancer, tumor cells expressing CD47 evade phagocytosis by macrophages, leading to a poor patient prognosis. However, the status of CD47 expression in solid tumors, particularly in gastric cancer, is not well understood ...
Sudo, Tomoya, Takahashi, Yusuke, Sawada, Genta, Uchi, Ryutaro, Mimori, Koshi, Akagi, Yoshito   +5 more
openaire   +3 more sources

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

CD47 knockout mice exhibit improved recovery from spinal cord injury

Neurobiology of Disease, 2011
Recent data have implicated thrombospondin-1 (TSP-1) signaling in the acute neuropathological events that occur in microvascular endothelial cells (ECs) following spinal cord injury (SCI) (Benton et al., 2008b).
Scott A. Myers, William H. DeVries, Kariena R. Andres, Mark J. Gruenthal, Richard L. Benton, James B. Hoying, Theo Hagg, Scott R. Whittemore   +7 more
doaj   +1 more source

m6A-methylated KCTD21-AS1 regulates macrophage phagocytosis through CD47 and cell autophagy through TIPR

Communications Biology
Blocking immune checkpoint CD47/SIRPα is a useful strategy to engineer macrophages for cancer immunotherapy. However, the roles of CD47-related noncoding RNA in regulating macrophage phagocytosis for lung cancer therapy remain unclear. This study aims to
Dongmin Liang, You-Jie Li, Jia-Xiang Zhang, Huan-Huan Shen, Chun-Xia Wu, Ning Xie, Yan Liang, Yan-Mei Li, Jiang-Nan Xue, Hongfang Sun, Qin Wang, Jian Yang, Xiao-Hua Li, Pingyu Wang, Shu-Yang Xie   +14 more
semanticscholar   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source