Results 91 to 100 of about 29,411 (265)

CD47-Blocking Antibodies and Atherosclerosis

JACC: Basic to Translational Science, 2016
Phagocytosis is a well understood process whereby pathogens and cell debris are removed from within the body, and it is an important homeostatic mechanism in health and disease. What is less commonly discussed is the process of “efferocytosis.” This term, derived from the Latin prefix effero- ,
openaire   +3 more sources

Targeting CD47 in cancer with bispecific antibodies

, 2017
CD47 is a ubiquitously expressed immune checkpoint receptor playing a major role in recognition of self by phagocytes. CD47 interacts with SIRPα to generate an inhibitory signal blocking phagocytosis.
Dheilly, Elie
core   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

The role of CD47 in non-neoplastic diseases

, 2023
CD47 is a 50 kDa five-spanning membrane receptor that plays a crucial role in multiple cellular processes, including myeloid cell activation, neutrophils transmigration, vascular remodeling, leukocyte adhesion and trans-endothelial migration.
Chao Wang, Ying Feng, Yaqing Lv, Deepali Patel, Hai Zhao, Hongwei Xie   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology
CD47 is best known for its role in tumor immune evasion; however, studies in diverse cell models indicate that it also has cell autonomous, tumor‐promoting functions which are cell type‐ and context‐specific.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
doaj   +1 more source

Tuning the radio with CD47 [PDF]

Science-Business eXchange, 2009
NCI researchers think they have found a strategy that not only protects healthy tissue during radiation treatment but also enhances antitumor response, most likely by protecting tumor-infiltrating immune cells.
openaire   +1 more source

PD-L1 and CD47 scoring

, 2019
Table scoring PD-L1 and CD47 intensity and %TC ...
Sean Hall (6503201)
core   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

CD47 [PDF]

Science-Business eXchange, 2012
David D. Roberts, David R. Soto-Pantoja, Jeff S. Isenberg   +2 more
openaire   +2 more sources

Normal locomotor activity in CD47 KO mice.

, 2014
In the open field test, (A) CD47 KO mice stayed significantly longer in the center of area of the apparatus than wild-type mice during the earlier part of the experimental period, but not over the entire experimental period.
Hiroshi Ohnishi (80020), Keizo Takao (105704), Takashi Matozaki (132458), Hisatsugu Koshimizu (526691), Tsuyoshi Miyakawa (105708)   +4 more
core   +1 more source