Results 91 to 100 of about 42,056 (305)

CD47 Blockade by Hu5F9‐G4 and Rituximab in Non‐Hodgkin's Lymphoma

New England Journal of Medicine, 2018
Background The Hu5F9‐G4 (hereafter, 5F9) antibody is a macrophage immune checkpoint inhibitor blocking CD47 that induces tumor‐cell phagocytosis. 5F9 synergizes with rituximab to eliminate B‐cell non‐Hodgkin's lymphoma cells by enhancing macrophage ...
R. Advani, I. Flinn, L. Popplewell, A. Forero, N. Bartlett, N. Ghosh, J. Kline, M. Roschewski, A. LaCasce, G. Collins, T. Tran, J. Lynn, James Y Chen, J. Volkmer, B. Agoram, Jie Huang, R. Majeti, I. Weissman, C. Takimoto, M. Chao, Sonali M. Smith   +20 more
semanticscholar   +1 more source

SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis

Journal of Clinical Investigation, 2023
SIPRα on macrophages binds with CD47 to resist proengulfment signals, but how the downstream signal of SIPRα controls tumor-infiltrating macrophages (TIMs) is still poorly clarified.
Yiqing Li, Hui Zhou, Pan Liu, Dan Lv, Yichun Shi, B. Tang, Jiaqi Xu, T. Zhong, Wangting Xu, Jie Zhang, Jianying Zhou, K. Ying, Yongchao Zhao, Yi Sun, Zhinong Jiang, Hongqiang Cheng, Xue Zhang, Y. Ke   +17 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

A novel anti-CD47 antibody with therapeutic potential for NK/T-cell lymphoma

Human Vaccines & Immunotherapeutics
NK/T-cell lymphoma (NKTCL) is a rare type of non-Hodgkin lymphoma (NHL). Although L-asparaginase-based chemotherapy has significantly improved survival in early-stage patients, the prognosis is poor in advanced and relapsed or refractory patients.
Liping Qin, Yajun Li, Ruolan Zeng, Yizi He, Xiaoyan Chen, Ling Xiao, Hui Zhou   +6 more
doaj   +1 more source

Targeting CD47-SIRPa axis shows potent preclinical anti-tumor activity as monotherapy and synergizes with PARP inhibition

npj Precision Oncology, 2023
The objective was to correlate CD47 gene expression with resistance to immune checkpoint inhibitors (ICI) in tumor tissue of gynecological cancer (GC).
Hussein Al-Sudani, Ying Ni, Philip Jones, Huseyin Karakilic, Lei Cui, Lisa D. S. Johnson, Peter G. Rose, Alexander Olawaiye, Robert P. Edwards, Robert A. Uger, Gloria H. Y. Lin, Haider Mahdi   +11 more
doaj   +1 more source

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. [PDF]

, 2019
Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are capable of evading clearance by macrophages through the overexpression of anti-
Barkal, Amira A, Barkal, Layla J, Barkal, Sammy A, Brewer, Rachel E, Dorigo, Oliver, Hatakeyama, Jason, Kowarsky, Mark, Krishnan, Venkatesh, Markovic, Maxim, Weissman, Irving L, Zaro, Balyn W   +10 more
core  

Intracellular and extracellular synergistic therapy for restoring macrophage functions via anti-CD47 antibody-conjugated bifunctional nanoparticles in atherosclerosis

Bioactive Materials
Atherosclerosis is a significant contributor to global cardiovascular disease. Reducing the formation of atherosclerotic plaque effectively can lead to a decrease in cardiovascular diseases. Therefore, controlling macrophage function is crucial.
Qiang Luo, Liqun Dai, Junli Li, He Chen, Y. Hao, Qing Li, Lili Pan, Chengxiang Song, Zhiyong Qian, Mao Chen   +9 more
semanticscholar   +1 more source

Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect

Nature Cancer, 2022
Radiation therapy is a mainstay of cancer treatment but does not always lead to complete tumor regression. Here we combine radiotherapy with blockade of the ‘don’t-eat-me’ cell-surface molecule CD47 in small cell lung cancer (SCLC), a highly metastatic ...
Y. Nishiga, Alexandros P. Drainas, M. Baron, Debadrita Bhattacharya, Amira A. Barkal, Yasaman Ahrari, Rebecca Mancusi, Jason B. Ross, N. Takahashi, Anish Thomas, M. Diehn, I. Weissman, E. Graves, J. Sage   +13 more
semanticscholar   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Attenuation of CD47-SIRPα Signal in Cholangiocarcinoma Potentiates Tumor-Associated Macrophage-Mediated Phagocytosis and Suppresses Intrahepatic Metastasis

Translational Oncology, 2019
The involvement of chronic inflammation in cholangiocarcinoma (CCA) progression is well established. Cluster of differentiation 47 (CD47) is mutually expressed in various cancers and serves as a protective signal for phagocytic elimination.
Kulthida Vaeteewoottacharn, Ryusho Kariya, Phattarin Pothipan, Sawako Fujikawa, Chawalit Pairojkul, Sakda Waraasawapati, Kazuhiko Kuwahara, Chaisiri Wongkham, Sopit Wongkham, Seiji Okada   +9 more
doaj   +1 more source