Results 71 to 80 of about 42,056 (305)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma [PDF]

, 2016
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is often associated with metastasis and recurrence leading to a poor prognosis. Therefore, development of novel treatment regimens is urgently needed to improve the survival of HCC patients. In this study,
Chan, VSF, Cheng, YLB, Cheung, CH, Ching, HH, Lau, YT, Lee, KW, Lo, J, Lu, P, Ma, KF, Ng, IOL, So, TY   +10 more
core   +1 more source

Targeting the CD47/SIRPα pathway in malignancies: recent progress, difficulties and future perspectives

Frontiers in Oncology
Since its initial report in 2015, CD47 has garnered significant attention as an innate immune checkpoint, raising expectations to become the next “PD-1.” The optimistic early stages of clinical development spurred a flurry of licensing deals for CD47 ...
Chenyang Jiang, Hao Sun, Zhongxin Jiang, Wenzhi Tian, S. Cang, Jifeng Yu   +5 more
semanticscholar   +1 more source

ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer

Science immunology, 2022
Radiotherapy (RT) of colorectal cancer (CRC) can prime adaptive immunity against tumor-associated antigen (TAA)–expressing CRC cells systemically. However, abscopal tumor remissions are extremely rare, and the postirradiation immune escape mechanisms in ...
Rodney Cheng-En Hsieh, Sunil Krishnan, R. Wu, Akash R. Boda, Arthur J Liu, Michelle Winkler, Wen-Hao Hsu, Steven H. Lin, M. Hung, Li-Chuan Chan, K. Bhanu, Anupallavi Srinivasamani, R. Azevedo, Y. Chou, R. DePinho, M. Gubin, E. Vilar-Sánchez, Chao-Hsien Chen, R. Slay, P. Jayaprakash, Shweta M. Hegde, Genevieve Hartley, Spencer T Lea, Rishika Prasad, Brittany Morrow, C. Couillault, Madeline Steiner, Chun-Chieh Wang, B. Venkatesulu, C. Taniguchi, Betty Y. S. Kim, Junjie Chen, N. Rudqvist, M. Curran   +33 more
semanticscholar   +1 more source

Tuning the radio with CD47 [PDF]

Science-Business eXchange, 2009
NCI researchers think they have found a strategy that not only protects healthy tissue during radiation treatment but also enhances antitumor response, most likely by protecting tumor-infiltrating immune cells.
openaire   +1 more source

Effect of CD47 Blockade on Vascular Inflammation

New England Journal of Medicine, 2021
Effect of CD47 Blockade on Vascular Inflammation Patients in a trial of the anti-CD47 antibody magrolimab for treatment of lymphoma underwent 18F-FDG PET–CT.
Kai-Uwe Jarr, Ryusuke Nakamoto, Brandon H. Doan, Yoko Kojima, Irving L. Weissman, Ranjana H. Advani, Andrei Iagaru, Nicholas J. Leeper   +7 more
openaire   +2 more sources

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Phenotypic characterization of aberrant stem and progenitor cell populations in myelodysplastic syndromes [PDF]

, 2018
Recent reports have revealed myelodysplastic syndromes (MDS) to arise from cancer stem cells phenotypically similar to physiological hematopoietic stem cells.
Flenner, Eva, Flörcken, Anne, Ostendorf, Benjamin N., Westermann, Jörg   +3 more
core   +3 more sources

CD47–SIRPα-targeted therapeutics: status and prospects

Immuno-Oncology Technology, 2022
CD47 is a “don’t eat me” signal to phagocytes that is overexpressed on many tumor cells as a potential mechanism for immune surveillance evasion. CD47 and its interaction with signal-regulating protein alpha (SIRPα) on phagocytes is therefore a promising
R. Maute, Jin Xu, I. Weissman
semanticscholar   +1 more source

CD47 on artificial structures

Aging, 2015
CD47, a “marker of self”, also referred to as integrin-associated protein (IAP) due to association with integrins such as αVβ3, has been first described by Brown et al. in 1990. As member of the immunoglobulin superfamily it contains one IgV-like domain and five transmembrane regions.
openaire   +2 more sources