Results 41 to 50 of about 42,056 (305)

Evidence that the degree of band 3 phosphorylation modulates human erythrocytes nitric oxide efflux – in vitro model of hyperfibrinogenemia [PDF]

, 2011
© 2011 – IOS Press and the authors. All rights reservedRecent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO ...
Almeida, J. P. Lopes de, Freitas-Santos, T., Saldanha, C.   +2 more
core   +1 more source

Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice

OncoImmunology, 2022
CD47 has established roles in the immune system for regulating macrophage phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory roles in natural killer and CD8+ T cells.
Pulak R. Nath, Dipasmita Pal-Nath, Sukhbir Kaur, Arunkumar Gangaplara, Thomas J. Meyer, Margaret C Cam, David D. Roberts   +6 more
doaj   +1 more source

Hepatitis C virus infection and related liver disease: the quest for the best animal model [PDF]

, 2013
Hepatitis C virus (HCV) is a major cause of cirrhosis and hepatocellular carcinoma (HCC) making the virus the most common cause of liver failure and transplantation.
Baumert, Thomas F, Mailly, Laurent, Meuleman, Philip, Robinet, Eric, Zeisel, Mirjam   +4 more
core   +3 more sources

CD47 as a promising therapeutic target in oncology

Frontiers in Immunology, 2022
CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular phagocytosis by macrophages, determines life span of individual erythrocytes, regulates activation of immune cells, and manipulates synaptic pruning during neuronal development. As
Hai Zhao, Shuangshuang Song, Junwei Ma, Zhiyong Yan, Hongwei Xie, Ying Feng, Shusheng Che   +6 more
openaire   +3 more sources

TIGIT/CD47 dual high expression predicts prognosis and is associated with immunotherapy response in lung squamous cell carcinoma

Thoracic Cancer, 2022
Background Recent studies indicated that T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) and cluster of differentiation 47 (CD47) have emerged as new potential immunotherapy targets.
Yue Peng, Bin Qiu, Fengwei Tan, Jiachen Xu, Fenglong Bie, Huayu He, Lei Liu, He Tian, Guangyu Bai, Bolun Zhou, Yuan Li, Qilin Huai, Zhenlin Yang, Shugeng Gao   +13 more
doaj   +1 more source

Influence of sex steroids on the viability and CD11b, CD18 and CD47 expression of blood neutrophils from dairy cows in the last month of gestation [PDF]

, 2006
In the period around parturition, cows experience an increased susceptibility for the development of Escherichia coli mastitis. This increased susceptibility has been correlated with a decreased functionality of neutrophils.
Burvenich, Christian, De Ketelaere, Adelheid, Duchateau, Luc, Lamote, Inge, Meyer, Evelyne   +4 more
core   +4 more sources

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103⁺CD11b⁺ DCs in the intestinal lamina propria [PDF]

, 2014
Signal regulatory protein alpha (SIRP alpha/CD172a) is a conserved transmembrane protein thought to play an inhibitory role in immune function by binding the ubiquitous ligand CD47.
Bain, Bain, Barclay, Barclay, Basu, Bimczok, Bogunovic, Cerovic, Cerovic, Coombes, del Rio, Fortin, Fukunaga, Goto, Inagaki, Iwamura, Kanazawa, Latour, Lewis, Lindberg, Liu, Lécuyer, Matozaki, Matteoli, Milling, Motegi, Naik, Okuzawa, Pabst, Persson, Persson, Raymond, Raymond, Saito, Satpathy, Schlitzer, Schraml, Schulz, Scott, Scott, Sun, Takai, Tamoutounour, Tomizawa, Varol, Waclavicek, Watchmaker, Welty, Westlund   +48 more
core   +2 more sources

CD47 blockade reverses resistance to HDAC inhibitor by liberating anti-tumor capacity of macrophages

Journal of experimental & clinical cancer research : CR
Targeting oncogenic histone modification by histone deacetylase inhibitors (HDACis) demonstrates promising prospects in clinical cancer treatment, whereas a notable proportion of patients cannot benefit from HDACi therapy.
Xutao Xu, Qianqian Wang, Ke Guo, Junjie Xu, Yunkun Lu, Huijuan Chen, Weiling Hu, Yilin Fu, Lu-de Sun, Ying He, Zhehang Chen, Wenhao Xia, Mengtian Pan, Beibei Lin, Wenjuan Yang, Qingqing Wang, Zhenzhen Wen, Q. Cao, Peng Xiao   +18 more
semanticscholar   +1 more source

Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy

Nature Communications, 2023
Pro-tumoral macrophages in lung tumors present a significant challenge in immunotherapy. Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral macrophages and dendritic cells.
Yuedong Guo, Qunqun Bao, Ping Hu, Jianlin Shi   +3 more
semanticscholar   +1 more source

CD47 in Osteosarcoma: Correlation with Metastasis and Macrophage-Mediated Phagocytosis

Cells
CD47 is expressed on cell surfaces and acts as a “don’t eat me” signal by interacting with signal-regulatory protein-α on the macrophage surface. Some cancer cells express CD47 protein and can evade macrophage phagocytosis.
Yunmi Ko, Seog-Yun Park, Jong Woong Park, June Hyuk Kim, Hyun Guy Kang, Jun Ah Lee   +5 more
doaj   +1 more source