Results 21 to 30 of about 42,056 (305)
CD47(low) status on CD4 effectors is necessary for the contraction/resolution of the immune response in humans and mice. [PDF]
PLoS ONE, 2012 How do effector CD4 T cells escape cell death during the contraction of the immune response (IR) remain largely unknown. CD47, through interactions with thrombospondin-1 (TSP-1) and SIRP-α, is implicated in cell death and phagocytosis of malignant cells.
Vu Quang Van +12 more
doaj +1 more source
CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications
Diagnostics, 2022 CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma
Seongsik Bang +8 more
doaj +1 more source
Frontiers in Oncology, 2020 Purposes: To measure expression levels of CD47 during endometrial carcinoma development, and to determine specific modulatory effects.Methods: CD47 expression levels in endometrial carcinoma tissues and adjacent tissues were analyzed using qRT-PCR.
Yun Liu +6 more
doaj +1 more source
Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer
Journal of Immunology Research, 2023 Background. CD47 has high levels of expression in malignant cancer cells, which binds to SIRP-α to release the “don’t eat me” signal and prevents mononuclear macrophages from phagocytosing the cells.
Qianqian Wang +8 more
doaj +1 more source
CD47 expression is critical for CAR T-cell survival in vivo
Journal for ImmunoTherapy of Cancer, 2023 Background CD47 is an attractive immunotherapeutic target because it is highly expressed on multiple solid tumors. However, CD47 is also expressed on T cells.
Stephen Gottschalk +8 more
doaj +1 more source
Circulation Research, 2007 See related article, pages 712–720 Thrombospondin-1 (TSP-1) is a homotrimeric glycoprotein with multiple functional domains that serves as a key mediator of a number of diverse cellular and physiologic processes.1 TSP-1 is the major component of the α granule of platelets.
David J, Kaczorowski, Timothy R, Billiar
openaire +2 more sources
Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]
, 2019 Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong +14 more
core +2 more sources
Thrombospondin-1/CD47 interaction regulates Th17 and treg differentiation in psoriasis [PDF]
, 2019 Accumulating evidence on the role of Thrombospondin-1 (TSP-1) in the immune response has emerged during the last years. In spite of the importance of TSP-1 not only as anti-angiogenic factor but also as an immunomodulatory molecule, studies on the ...
Calzada, María J. +11 more
core +2 more sources
Regulation of CD47 expression on CD14+ monocytes by interferon-α in PBC patients
Frontiers in Immunology, 2023 BackgroundPrimary biliary cholangitis (PBC) is a chronic intrahepatic cholestatic autoimmune liver disease characterized by inflammatory injury of small and medium-sized bile ducts in the liver.
Xi Su +8 more
doaj +1 more source
The landscape overview of CD47-based immunotherapy for hematological malignancies
Biomarker Research, 2023 Extensive clinical and experimental evidence suggests that macrophages play a crucial role in cancer immunotherapy. Cluster of differentiation (CD) 47, which is found on both healthy and malignant cells, regulates macrophage-mediated phagocytosis by ...
Hua Yang, Yang Xun, Hua You
semanticscholar +1 more source