Results 21 to 30 of about 29,411 (265)

CD47 Enhances Cell Viability and Migration Ability but Inhibits Apoptosis in Endometrial Carcinoma Cells via the PI3K/Akt/mTOR Signaling Pathway

Frontiers in Oncology, 2020
Purposes: To measure expression levels of CD47 during endometrial carcinoma development, and to determine specific modulatory effects.Methods: CD47 expression levels in endometrial carcinoma tissues and adjacent tissues were analyzed using qRT-PCR.
Yun Liu, Yue Chang, Xinhong He, Yixuan Cai, Hao Jiang, Ru Jia, Jiyan Leng   +6 more
doaj   +1 more source

Role of CD47 in Hematological Malignancies [PDF]

Journal of Hematology & Oncology, 2020
AbstractCD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent “don’t eat me” signal to prevent phagocytosis.
Entsar Eladl, Rosemarie Tremblay-LeMay, Nasrin Rastgoo, Rumina Musani, Wenming Chen, Aijun Liu, Hong Chang   +6 more
openaire   +4 more sources

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer [PDF]

, 2016
CD47 is a cell surface molecule that inhibits phagocytosis of cells that express it by binding to its receptor, SIRPα, on macrophages and other immune cells. CD47 is expressed at different levels by neoplastic and normal cells. Here, to reveal mechanisms
Young, Richard A., Clarke, Michael F., Weissman, Irving L., Sherwood, Richard I., Brian J. Abraham, Yiu, Ying Y., Gip, Phung, Ying Y. Yiu, Po Ho, Richard A. Young, Willingham, Stephen B., Mark Zarnegar, Nicholas J. Leeper, McKenna, Kelly, Somlo, George, Irving L. Weissman, Kuo, Angera H., Betancur, Paola A., Sherwood, Richard, Michael F. Clarke, Zarnegar, Mark, Leeper, Nicholas J., Phung Gip, Farnaz Khameneh, Kojima, Yoko, Abraham, Brian J., Angera H. Kuo, Paola A. Betancur, George Somlo, Khameneh, Farnaz, Ho, Po, Tomek Swigut, Yoko Kojima, Swigut, Tomek, Stephen B. Willingham, Kelly McKenna, Richard I. Sherwood   +36 more
core   +1 more source

CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications

Diagnostics, 2022
CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma
Seongsik Bang, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Hosub Park, Jaekyung Myung, Joo Yeon Ko, Hyunsung Kim, Seungsam Paik   +8 more
doaj   +1 more source

Targeting CD47 [PDF]

Circulation Research, 2007
See related article, pages 712–720 Thrombospondin-1 (TSP-1) is a homotrimeric glycoprotein with multiple functional domains that serves as a key mediator of a number of diverse cellular and physiologic processes.1 TSP-1 is the major component of the α granule of platelets.
David J, Kaczorowski, Timothy R, Billiar
openaire   +2 more sources

CD47 protein expression in acute myeloid leukemia: A tissue microarray-based analysis [PDF]

, 2015
Binding of CD47 to signal regulatory protein alpha (SIRPα), an inhibitory receptor, negatively regulates phagocytosis. In acute myeloid leukemia (AML), CD47 is overexpressed on peripheral blasts and leukemia stem cells and inversely correlates with ...
Banz Wälti, Yara, Zlobec, Inti, Schürch, Christian, Galli, Serena, Perren, Aurel, Ochsenbein, Adrian   +5 more
core   +1 more source

Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors

Frontiers in Oncology, 2019
Knockdown or gene disruption of the ubiquitously expressed cell surface receptor CD47 protects non-malignant cells from genotoxic stress caused by ionizing radiation or cytotoxic chemotherapy but sensitizes tumors in an immune competent host to genotoxic
Sukhbir Kaur, Anthony L. Schwartz, David G. Jordan, David R. Soto-Pantoja, Bethany Kuo, Abdel G. Elkahloun, Lesley Mathews Griner, Craig J. Thomas, Marc Ferrer, Anish Thomas, Sai-Wen Tang, Vinodh N. Rajapakse, Yves Pommier, David D. Roberts   +13 more
doaj   +1 more source

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Journal of Immunology Research, 2023
Background. CD47 has high levels of expression in malignant cancer cells, which binds to SIRP-α to release the “don’t eat me” signal and prevents mononuclear macrophages from phagocytosing the cells.
Qianqian Wang, Chunxaing Feng, Yuchun Chen, Tianming Peng, Yong Li, Kunlin Wu, Xiaoyong Pu, Hanzhong Chen, Jiumin Liu   +8 more
doaj   +1 more source

CD47 expression is critical for CAR T-cell survival in vivo

Journal for ImmunoTherapy of Cancer, 2023
Background CD47 is an attractive immunotherapeutic target because it is highly expressed on multiple solid tumors. However, CD47 is also expressed on T cells.
Stephen Gottschalk, Phuong Nguyen, Christopher DeRenzo, Giedre Krenciute, Alex N Beckett, Peter Chockley, Shondra M Pruett-Miller, Peter Vogel, Heather Sheppard   +8 more
doaj   +1 more source

Targeting the CD47-SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next-generation therapeutic strategies. [PDF]

Smart Mol
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Zhou R, Jing L, Zhang J, Guo C, Yang Q.
europepmc   +2 more sources