Results 11 to 20 of about 42,056 (305)
The CD47-SIRPα Immune Checkpoint.
Immunity, 2020 The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein, expressed on both healthy and cancer cells, plays a pivotal ...
Meike E. W. Logtenberg +2 more
semanticscholar +4 more sources
Targeting CD47 for cancer immunotherapy [PDF]
Journal of Hematology & Oncology, 2021 Much progress has been made in targeting CD47 for cancer immunotherapy in solid tumors (ST) and hematological malignancies. We summarized the CD47-related clinical research and analyzed the research trend both in the USA and in China.
Zhongxing Jiang +4 more
semanticscholar +4 more sources
CD47 is highly expressed in gliomas and targeting CD47 is a promising therapeutic strategy [PDF]
European Journal of Inflammation, 2021 Gliomas are very malignant brain tumors that are difficult to treat. CD47 is an antiphagocytic molecule that binds to SIPRα on phagocytes. It is overexpressed on the plasma membranes of multiple human tumor cell types and is an important diagnostic and ...
Jiaying Yang +5 more
doaj +2 more sources
Clinical and Translational MedicineCluster of differentiation 47 (CD47) occupies the outer membrane of human cells, where it binds to soluble and cell surface receptors on the same and other cells, sculpting their topography and resulting in a pleiotropic receptor‐multiligand interaction ...
Jeffrey S. Isenberg, Enrique Montero
semanticscholar +4 more sources
Facilitating cholangiocarcinoma inhibition by targeting CD47
Experimental and Molecular PathologyImmune evasion is one of the mechanisms by which cancer cells acquire immunity during cancer development and progression. One of these is the increased expression of cluster of differentiation 47 (CD47), a transmembrane glycoprotein that protects cells ...
Kulthida Vaeteewoottacharn +10 more
doaj +3 more sources
Structural–functional diversity of CD47 proteoforms
Frontiers in ImmunologyThe ubiquitously expressed transmembrane glycoprotein CD47 participates in various important physiological cell functions, including phagocytosis, apoptosis, proliferation, adhesion, and migration, through interactions with its ligands, including the ...
Ting Zhang, Feng Wang, Lu Xu, Yong Yang
semanticscholar +4 more sources
CD47 Potentiates Inflammatory Response in Systemic Lupus Erythematosus
Cells, 2021 Background: To investigate the role of CD47 in inflammatory responses in systemic lupus erythematosus (SLE). Methods: Expression of CD47 and signal regulatory protein alpha (SIRPα) by peripheral blood mononuclear cells (PBMCs) and changes in CD47 ...
Jin Kyun Park +4 more
doaj +1 more source
Nature Communications, 2023 As a key component of the standard of care for glioblastoma, radiotherapy induces several immune resistance mechanisms, such as upregulation of CD47 and PD-L1.
P. Zhang +18 more
semanticscholar +1 more source
Role of CD47 in Hematological Malignancies [PDF]
Journal of Hematology & Oncology, 2020 AbstractCD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent “don’t eat me” signal to prevent phagocytosis.
Entsar Eladl +6 more
openaire +4 more sources
CD47 as a Potential Target to Therapy for Infectious Diseases
Antibodies, 2020 The integrin associated protein (CD47) is a widely and moderately expressed glycoprotein in all healthy cells. Cancer cells are known to induce increased CD47 expression.
Lamin B. Cham +4 more
doaj +1 more source