Results 41 to 50 of about 4,584 (134)

A whole blood assay for antibody dependent phagocytosis of Plasmodium falciparum infected erythrocytes

Communications Medicine
Background Antibodies are used to protect against Plasmodium falciparum malaria. One antibody target, the variant surface antigens, is expressed on infected erythrocytes (IEs). Antibodies to these antigens can either block IE sequestration in the tissues,
Dilini Rathnayake, Wina Hasang, Alexander Macpherson, HongHua Ding, Laurens Manning, Moses Laman, Maria Ome-Kaius, Holger W. Unger, Feiko Ter Kuile, Mwayi Madanitsa, Bruce Wines, P. Mark Hogarth, Elizabeth H. Aitken, Stephen J. Rogerson   +13 more
doaj   +1 more source

Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis

OncoImmunology, 2021
Multiple Myeloma (MM) is a malignant disorder of plasma cells which, despite significant advances in treatment, remains incurable. Daratumumab, the first CD38 directed monoclonal antibody, has shown promising activity alone and in combination with other ...
Serika D Naicker, Claire L Feerick, Kevin Lynch, Dawn Swan, Cian McEllistrim, Robert Henderson, Niamh A Leonard, Oliver Treacy, Alessandro Natoni, Athina Rigalou, Joana Cabral, Christopher Chiu, Kate Sasser, Thomas Ritter, Michael O’Dwyer, Aideen E Ryan   +15 more
doaj   +1 more source

Vpu protects HIV-infected cells from antibody-dependent cellular phagocytosis by counteracting tetherin

Cell Reports
Summary: Tetherin is an interferon-inducible transmembrane protein that inhibits the detachment of enveloped viruses from infected cells. HIV-1 Vpu counteracts this restriction by removing tetherin from sites of virus release.
Brian J. Snow, Nida K. Keles, Ahmed Ali, Ryan T. Behrens, Sanath Kumar Janaka, David T. Evans   +5 more
doaj   +1 more source

Development of a Virus Particle-Based Antibody-Dependent Cellular Phagocytosis (ADCP) Assay for HIV

Abstract Antibody-dependent cellular phagocytosis (ADCP) is an Fc-mediated effector function that contributes to the clearance of pathogens, including HIV. Conventional bead-based ADCP assays using recombinant Env proteins offer scalability and reproducibility but do not recapitulate the structural, conformational and glycan features of
Chitra Upadhyay, Priyanka Gadam Rao
openaire   +2 more sources

Impact of an aerosolized or intramuscular adenovirus type 5-vectored COVID-19 vaccine on Fc-mediated immune effector functions in a hybrid immunity population

Frontiers in Immunology
BackgroundBeyond the role of neutralizing antibodies in protecting against SARS-CoV-2, Fc-mediated antibodies functions may offer additional immune defense.
Mingzhi Gan, Mingzhi Gan, Weiwei Han, Chuang Li, Simin Li, Zhuangzhuang Huang, Lingjie Xu, Xiaoyu Xu, Xiangjun Zhai, Xiangjun Zhai, Yuxin Chen, Jingxin Li, Jingxin Li   +12 more
doaj   +1 more source

In Vivo Immunoscoring Technique to Monitor Anti‐CD47 Immunotherapy Efficacy in Triple‐Negative Breast Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
Intravital imaging using MCP1‐FITC and dextran‐AF680 assesses macrophage targeting and polarization in murine 4T1 tumor models. Visualization of M1‐like and M2‐like macrophages and M1/M2 ratio quantification support evaluation of anti‐CD47 immunotherapy, highlighting the potential of macrophage‐targeted imaging for patient stratification and treatment ...
Minfeng Yang, Shiqiang Hou, Chi Ming Wong, Hongzhao Chen, Chunjin Jin, Song‐Bai Liu, Jung Sun Yoo   +6 more
wiley   +1 more source

CLDN18.2 in pancreatic ductal adenocarcinoma: Biomarker assessment, spatial heterogeneity and therapeutic modality selection

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review presents a framework for selecting Claudin 18.2 (CLDN18.2)‐directed treatment modalities in pancreatic ductal adenocarcinoma according to tumour antigen coverage and spatial distribution. Representative assessment at baseline and reassessment after progression can guide treatment adaptation over time.
Ruyu Tan, Zhexin Zhang, Jiaxin Wang, Roland Andersson, Daniel Ansari, Jinfei Chen   +5 more
wiley   +1 more source

Integrative Multiomics Profiling Reveals Immune Determinants of Response to Disitamab Vedotin Plus Penpulimab in HER2‐Low Breast Cancer

MedComm, Volume 7, Issue 10, October 2026.
This prospective single‐arm study evaluated neoadjuvant disitamab vedotin plus penpulimab in 20 patients with Stage II–III HER2‐low breast cancer. The regimen showed preliminary activity (pCR 20.0% intention‐to‐treat, 25.0% evaluable; ORR 56.3%) with manageable toxicity.
Xiaoxiao Liu, Yuting Song, Lei Liu, Aaron Qi Zhang, Xin Xie, Bing Wei, Ping He, Chunying Zhuang, Juanjuan Li, Xi Yan, Tinglun Tian, Xiaorong Zhong, Jie Chen, Yan Cheng, Dan Zheng, Shibao Li, Hao Wang, Ting Luo   +17 more
wiley   +1 more source

Associations Between Antibody Fc-Mediated Effector Functions and Long-Term Sequelae in Ebola Virus Survivors

Frontiers in Immunology, 2021
Antibodies that mediate non-neutralizing functions play an important role in the immune response to Ebola virus (EBOV) and are thought to impact disease outcome.
Dominic Paquin-Proulx, Dominic Paquin-Proulx, Bronwyn M. Gunn, Aljawharah Alrubayyi, Aljawharah Alrubayyi, Danielle V. Clark, Matthew Creegan, Matthew Creegan, Dohoon Kim, Dohoon Kim, Hannah Kibuuka, Monica Millard, Salim Wakabi, Leigh Anne Eller, Leigh Anne Eller, Nelson L. Michael, Randal J. Schoepp, Matthew J. Hepburn, Lisa E. Hensley, Merlin L. Robb, Merlin L. Robb, Galit Alter, Michael A. Eller   +22 more
doaj   +1 more source

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source