Results 61 to 70 of about 4,584 (134)

Fc-effector functional antibody assays for SARS-CoV-2 variants of concern

Frontiers in Immunology
BackgroundThe Fc regions of antibodies mediate important effector cell functions such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), antibody-dependent neutrophil phagocytosis (ADNP), and complement ...
Xuemin Chen, Grace Li, Caroline Ciric, Theda Gibson, Larry J. Anderson, Larry J. Anderson, Christina A. Rostad, Christina A. Rostad   +7 more
doaj   +1 more source

Cross-Reactive Fc-Mediated Antibody Responses to Influenza HA Stem Region in Human Sera Following Seasonal Vaccination

Vaccines
Background: Current influenza A vaccines primarily induce neutralizing antibodies targeting the variable hemagglutinin (HA) head domain, limiting their effectiveness against diverse or emerging influenza A virus (IAV) subtypes.
Ayae Nishiyama, Takuto Nogimori, Yuji Masuta, Tomoka Matsuura, Tetsuo Kase, Kyoko Kondo, Satoko Ohfuji, Yu Nakagama, Natsuko Kaku, Sachie Nakagama, Yuko Nitahara, Yoshimasa Takahashi, Hiroshi Kakeya, Yasutoshi Kido, Wakaba Fukushima, Takuya Yamamoto   +15 more
doaj   +1 more source

ESAT-6-specific antibody features and Fcγ receptor expression during pulmonary tuberculosis treatment: Implications for therapeutic monitoring

Biomolecules & Biomedicine
Tuberculosis (TB) remains a leading cause of global mortality, yet the long-term dynamics of antibody-mediated immunity during successful treatment are not fully understood.
Christian Elugo, Sandra Palma Albornoz, Yomara Romero, Sandra Delgado-Málaga, Iskra Tuero   +4 more
doaj   +1 more source

Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaques

iScience
Summary: Antibodies represent a primary mediator of protection against respiratory viruses. Serum neutralizing antibodies (NAbs) are often considered a primary correlate of protection.
Xin Tong, Qixin Wang, Wonyeong Jung, Taras M. Chicz, Ross Blanc, Lily J. Parker, Dan H. Barouch, Ryan P. McNamara   +7 more
doaj   +1 more source

Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality

Frontiers in Immunology
IntroductionRecent vaccine and infectious disease studies have highlighted the importance of antibodies that activate cellular Fc functions, including antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC ...
Suzanne K. Shoffner-Beck, Robert M. Theisen, Kade E. Wong, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Stephen Kent, Stephen Kent, Amy W. Chung, Kelly B. Arnold   +9 more
doaj   +1 more source

Rituximab-IgG2 is a phagocytic enhancer in antibody-based immunotherapy of B-cell lymphoma by altering CD47 expression

Frontiers in Immunology
Antibody-dependent cellular phagocytosis (ADCP) by monocytes and macrophages contributes significantly to the efficacy of many therapeutic monoclonal antibodies (mAbs), including anti-CD20 rituximab (RTX) targeting CD20+ B-cell non-Hodgkin lymphomas (NHL)
Oanh T. P. Nguyen, Sandra Lara, Giovanni Ferro, Matthias Peipp, Sandra Kleinau   +4 more
doaj   +1 more source

A genetically engineered mouse/human chimeric antibody targeting CD99 enhances antibody-dependent cellular phagocytosis against human mantle cell lymphoma Z138 cells

Journal of Associated Medical Sciences
Background: Mantle cell lymphoma (MCL) is an aggressive form of B-cell nonHodgkin lymphoma. The elimination of MCL cells via phagocytosis is essential for cancer eradication.
Kamonporn Kotemul, Supansa Pata, Witida Laopajon, Watchara Kasinrerk, Nuchjira Takheaw   +4 more
doaj   +1 more source

Fc-Mediated Effector Functions of Anti-NS1 Antibodies in Dengue

Viruses
The non-structural protein 1 (NS1) of dengue virus (DENV) plays a multifaceted role in viral pathogenesis and immune modulation. Although vaccine strategies have traditionally focused on neutralizing antibodies against the envelope (E) protein, recent ...
Romchat Kraivong
doaj   +1 more source

Targeted CD47 checkpoint blockade using a mesothelin-directed antibody construct for enhanced solid tumor-specific immunotherapy

Cancer Immunology, Immunotherapy
The immune checkpoint CD47 is highly upregulated in several cancers as an innate immune escape mechanism. CD47 delivers a “don’t eat me” signal to its co-receptor signal regulatory protein α (SIRPα), thereby inhibiting phagocytosis.
Anna Reischer, Alexandra Leutbecher, Björn Hiller, Enrico Perini, Kieron White, Alejandra Hernández-Cáceres, Alexandra Schele, Benjamin Tast, Lisa Rohrbacher, Lis Winter, Bastian Czogalla, Sven Mahner, Heinrich Flaswinkel, Heinrich Leonhardt, Lorenza Wyder, Christian Wichmann, Denis Maenner, Fabian Trillsch, Mirjana Kessler, Karl-Peter Hopfner, Nadja C. Fenn, Marion Subklewe   +21 more
doaj   +1 more source

Co-phagocytosis of VEGFA with HER2-overexpressing cancer cells induced by HER2-VEGFA–bispecific antibodies improves antitumor responses

JCI Insight
We conceived of a type of antitumor mechanism of action by which a soluble target in the tumor microenvironment, such as a tumor-driving growth factor, can be phagocytized along with cancer cells via antibody-dependent cellular phagocytosis (ADCP) using ...
Yang Lu, Songbo Qiu, Zhen Fan
doaj   +1 more source