Results 11 to 20 of about 78,855 (233)

Macrophage N-glycan processing inhibits antibody-dependent cellular phagocytosis. [PDF]

Glycobiology, 2023
Abstract Factors regulating macrophage effector function represent potential targets to optimize the efficacy of antibody-mediated therapies. Macrophages are myeloid cells capable of engulfing and destroying diseased or damaged target cells. Antibodies binding to the target cell surface can engage macrophage Fc gamma receptors (FcγRs) to
Díaz de León JSA, Aguilar I, Barb AW.
europepmc   +3 more sources

Fluorescent detection of peroxynitrite during antibody-dependent cellular phagocytosis. [PDF]

Methods Enzymol, 2020
Peroxynitrite (PNT) is a highly reactive oxidant that plays a key role in the destruction of foreign pathogens by specific phagocytic immune cells such as macrophages. However, when its production is dysregulated, this oxidant can contribute to cardiovascular disease, neurological diseases, and cancer. To facilitate the detection of PNT in living cells,
Rane D, Carlson EJ, Yin Y, Peterson BR.
europepmc   +4 more sources

Impact of IgG Isotype on the Induction of Antibody-Dependent Cellular Phagocytosis of HIV by Human Milk Leukocytes. [PDF]

Front Immunol, 2022
Approximately 100,000 mother-to-child transmission (MTCT) events of HIV via human milk feeding occur each year. However, only about 15% of infants milk-fed by untreated HIV+ mothers become infected, suggesting a protective effect of the milk itself. Infants ingest 10 5
Fox A, Liu X, Zolla-Pazner S, Powell RL.
europepmc   +5 more sources

Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab. [PDF]

Mol Cancer Ther, 2018
Abstract Elotuzumab, a recently approved antibody for the treatment of multiple myeloma, has been shown to stimulate Fcγ receptor (FcγR)-mediated antibody-dependent cellular cytotoxicity by natural killer (NK) cells toward myeloma cells.
Kurdi AT, Glavey SV, Bezman NA, Jhatakia A, Guerriero JL, Manier S, Moschetta M, Mishima Y, Roccaro A, Detappe A, Liu CJ, Sacco A, Huynh D, Tai YT, Robbins MD, Azzi J, Ghobrial IM.   +16 more
europepmc   +4 more sources

Exploring the impact of antibody-dependent cellular phagocytosis-related genes on the prognosis of metastatic melanoma. [PDF]

PLoS One
Background Metastatic melanoma is a challenging clinical condition with poor prognosis. Recent research has highlighted the role of antibody-dependent cellular phagocytosis (ADCP) in tumor immunity, suggesting prognostic implications for ADCP-related genes (ARGs).
Chen J, He J, Xu X, Sun H, Zhang J.
europepmc   +3 more sources

CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis. [PDF]

JCI Insight, 2019
The HER2-specific monoclonal antibody (mAb), trastuzumab, has been the mainstay of therapy for HER2 + breast cancer (BC) for approximately 20 years. However, its therapeutic mechanism of action (MOA) remains unclear, with antitumor responses to trastuzumab remaining heterogeneous and ...
Tsao LC, Crosby EJ, Trotter TN, Agarwal P, Hwang BJ, Acharya C, Shuptrine CW, Wang T, Wei J, Yang X, Lei G, Liu CX, Rabiola CA, Chodosh LA, Muller WJ, Lyerly HK, Hartman ZC.   +16 more
europepmc   +4 more sources

Preclinical evaluation of AFM24, a novel CD16A-specific innate immune cell engager targeting EGFR-positive tumors

mAbs, 2021
Epidermal growth factor receptor (EGFR)-targeted cancer therapy such as anti-EGFR monoclonal antibodies and tyrosine kinase inhibitors have demonstrated clinical efficacy.
Susanne Wingert, Uwe Reusch, Stefan Knackmuss, Michael Kluge, Michael Damrat, Jens Pahl, Ute Schniegler-Mattox, Thomas Mueller, Ivica Fucek, Kristina Ellwanger, Michael Tesar, Torsten Haneke, Joachim Koch, Martin Treder, Wolfgang Fischer, Erich Rajkovic   +15 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule. [PDF]

FEBS Open Bio
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Koutsogiannaki S, Alhamdan F, Malm E, Bermudez M, Kim SY, Yuki K.   +5 more
europepmc   +2 more sources

Protocol for antibody-dependent cellular phagocytosis assay with controlled IgG concentrations in tested samples. [PDF]

STAR Protoc
St Germain R, Sholukh AM.
europepmc   +2 more sources

Multi-omics identification of an antibody dependent cellular phagocytosis related signature for hepatocellular carcinoma. [PDF]

Transl Cancer Res
Yin X, Yin W, Yan Q, Zheng S, Li Y, Zhong X.   +5 more
europepmc   +2 more sources