Results 11 to 20 of about 174,708 (252)

Fc glycan sialylation of biotherapeutic monoclonal antibodies has limited impact on antibody‐dependent cellular cytotoxicity [PDF]

FEBS Open Bio, 2021
Scott Kuhns, Elaine Branstetter, Rupa Padaki   +2 more
exaly   +2 more sources

Negative interference with antibody-dependent cellular cytotoxicity mediated by rituximab from its interactions with human serum proteins [PDF]

Frontiers in Immunology, 2023
Yuki Yamaguchi, Hirokazu Yagi, Rina Yogo   +2 more
exaly   +2 more sources

Harnessing the immunomodulatory effects of exercise to enhance the efficacy of monoclonal antibody therapies against B-cell haematological cancers: a narrative review

Frontiers in Oncology, 2023
Therapeutic monoclonal antibodies (mAbs) are standard care for many B-cell haematological cancers. The modes of action for these mAbs include: induction of cancer cell lysis by activating Fcγ-receptors on innate immune cells; opsonising target cells for ...
Harrison D. Collier-Bain, Frankie F. Brown, Frankie F. Brown, Adam J. Causer, Annabelle Emery, Rebecca Oliver, Rebecca Oliver, Sally Moore, James Murray, James E. Turner, James E. Turner, John P. Campbell   +11 more
doaj   +1 more source

Contribution of Fc-dependent cell-mediated activity of a vestigial esterase-targeting antibody against H5N6 virus infection

Emerging Microbes and Infections, 2020
The highly pathogenic avian influenza A (H5N6) virus has caused sporadic human infections with a high case fatality rate. Due to the continuous evolution of this virus subtype and its ability to transmit to humans, there is an urgent need to develop ...
Zhiqiang Zheng, Su Hui Catherine Teo, Suganya Cheyyatraivendran Arularasu, Zhehao Liu, Nur Khairiah Mohd-Ismail, Chee Keng Mok, Chee Bing Ong, Justin Jang-hann Chu, Yee-Joo Tan   +8 more
doaj   +1 more source

An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity

Nature Communications, 2023
The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent ...
Nina E. Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O’Toole, Elizabeth Whalen, Peter W. Y. Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E. Atkinson, Jason Baardsnes, Liam J. Worrall, Duncan Browman, Emma E. Smith, Priya Baichoo, Chi Wing Cheng, Joy Guedia, Sohyeong Kang, Abhishek Mukhopadhyay, Lisa Newhook, Anders Ohrn, Prajwal Raghunatha, Matteo Zago-Schmitt, Joseph D. Schrag, Joel Smith, Patricia Zwierzchowski, Joshua M. Scurll, Vincent Fung, Sonia Black, Natalie C. J. Strynadka, Michael R. Gold, Leonard G. Presta, Gordon Ng, Surjit Dixit   +38 more
doaj   +1 more source

Considerations of Antibody Geometric Constraints on NK Cell Antibody Dependent Cellular Cytotoxicity

Frontiers in Immunology, 2020
It has been well-established that antibody isotype, glycosylation, and epitope all play roles in the process of antibody dependent cellular cytotoxicity (ADCC).
Charles D. Murin
doaj   +1 more source

Mechanisms of Action of the New Antibodies in Use in Multiple Myeloma

Frontiers in Oncology, 2021
Monoclonal antibodies (mAbs) directed against antigen-specific of multiple myeloma (MM) cells have Fc-dependent immune effector mechanisms, such as complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and antibody ...
Alessandra Romano, Paola Storti, Valentina Marchica, Grazia Scandura, Laura Notarfranchi, Luisa Craviotto, Luisa Craviotto, Francesco Di Raimondo, Francesco Di Raimondo, Nicola Giuliani   +9 more
doaj   +1 more source

Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells

Frontiers in Immunology, 2021
CD38 is the major NAD+-hydrolyzing ecto-enzyme in most mammals. As a type II transmembrane protein, CD38 is also a promising target for the immunotherapy of multiple myeloma (MM).
Natalie Baum, Marie Eggers, Julia Koenigsdorf, Julia Koenigsdorf, Stephan Menzel, Stephan Menzel, Julia Hambach, Julia Hambach, Tobias Staehler, Ralf Fliegert, Frederike Kulow, Gerhard Adam, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte   +14 more
doaj   +1 more source

Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

Molecular Cancer, 2011
Background Proteolytic enzymes have been implicated in driving tumor progression by means of their cancer cell microenvironment activity where they promote proliferation, differentiation, apoptosis, migration, and invasion.
Kwok Hang Fai, Buick Richard J, Kuehn Diana, Gormley Julie A, Doherty Declan, Jaquin Thomas J, McClurg Angela, Ward Claire, Byrne Teresa, Jaworski Jacob, Leung Ka Lai, Snoddy Philip, McAnally Christine, Burden Roberta E, Gray Breena, Lowry Jenny, Sermadiras Isabelle, Gruszka Natalia, Courtenay-Luck Nigel, Kissenpfennig Adrien, Scott Christopher J, Johnston James A, Olwill Shane A   +22 more
doaj   +1 more source

Antibody-dependent cellular cytotoxicity in HIV infection [PDF]

AIDS, 2018
: Interactions between the Fc segment of IgG and its receptors (FcγRs) found on cells such as natural killer cells, monocytes, macrophages and neutrophils can potentially mediate antiviral effects in the setting of HIV and related infections. We review the potential role of FcγR interactions in HIV, SIV and SHIV infections, with an emphasis on antibody-
Forthal, Donald N, Finzi, Andrés
openaire   +4 more sources