Results 11 to 20 of about 183,067 (255)

Influenza and Antibody-Dependent Cellular Cytotoxicity

Frontiers in Immunology, 2019
Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral escape from immune pressure, and recombination ...
Tarra A. Von Holle, M. Anthony Moody, M. Anthony Moody, M. Anthony Moody   +3 more
doaj   +3 more sources

Considerations of Antibody Geometric Constraints on NK Cell Antibody Dependent Cellular Cytotoxicity

Frontiers in Immunology, 2020
It has been well-established that antibody isotype, glycosylation, and epitope all play roles in the process of antibody dependent cellular cytotoxicity (ADCC).
Charles D. Murin
doaj   +1 more source

Protective Role of NS1-Specific Antibodies in the Immune Response to Dengue Virus Through Antibody-Dependent Cellular Cytotoxicity. [PDF]

J Infect Dis
Sanchez-Vargas LA, Mathew A, Salje H, Sousa D, Casale NA, Farmer A, Buddhari D, Anderson K, Iamsirithaworn S, Kaewhiran S, Friberg H, Currier JR, Rothman AL.   +12 more
europepmc   +2 more sources

Mechanisms of Action of the New Antibodies in Use in Multiple Myeloma

Frontiers in Oncology, 2021
Monoclonal antibodies (mAbs) directed against antigen-specific of multiple myeloma (MM) cells have Fc-dependent immune effector mechanisms, such as complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and antibody ...
Alessandra Romano, Paola Storti, Valentina Marchica, Grazia Scandura, Laura Notarfranchi, Luisa Craviotto, Luisa Craviotto, Francesco Di Raimondo, Francesco Di Raimondo, Nicola Giuliani   +9 more
doaj   +1 more source

Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells

Frontiers in Immunology, 2021
CD38 is the major NAD+-hydrolyzing ecto-enzyme in most mammals. As a type II transmembrane protein, CD38 is also a promising target for the immunotherapy of multiple myeloma (MM).
Natalie Baum, Marie Eggers, Julia Koenigsdorf, Julia Koenigsdorf, Stephan Menzel, Stephan Menzel, Julia Hambach, Julia Hambach, Tobias Staehler, Ralf Fliegert, Frederike Kulow, Gerhard Adam, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte   +14 more
doaj   +1 more source

Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

Molecular Cancer, 2011
Background Proteolytic enzymes have been implicated in driving tumor progression by means of their cancer cell microenvironment activity where they promote proliferation, differentiation, apoptosis, migration, and invasion.
Kwok Hang Fai, Buick Richard J, Kuehn Diana, Gormley Julie A, Doherty Declan, Jaquin Thomas J, McClurg Angela, Ward Claire, Byrne Teresa, Jaworski Jacob, Leung Ka Lai, Snoddy Philip, McAnally Christine, Burden Roberta E, Gray Breena, Lowry Jenny, Sermadiras Isabelle, Gruszka Natalia, Courtenay-Luck Nigel, Kissenpfennig Adrien, Scott Christopher J, Johnston James A, Olwill Shane A   +22 more
doaj   +1 more source

Bispecific antibody-activated T cells enhance NK cell-mediated antibody-dependent cellular cytotoxicity

Journal of Hematology & Oncology, 2021
Resistance to anti-cancer monoclonal antibody (mAb) therapy remains a clinical challenge. Previous work in our laboratory has shown that T cell help in the form of interleukin-2 maintains long-term NK cell viability and NK cell-mediated antibody ...
Zhaoming Wang, Chaobo Yin, Lawrence G. Lum, Andrean Simons, George J. Weiner   +4 more
doaj   +1 more source

Comparative efficiency of HIV-1-infected T cell killing by NK cells, monocytes and neutrophils.

PLoS ONE, 2013
HIV-1 infected cells are eliminated in infected individuals by a variety of cellular mechanisms, the best characterized of which are cytotoxic T cell and NK cell-mediated killing.
Adjoa Smalls-Mantey, Mark Connors, Quentin J Sattentau   +2 more
doaj   +1 more source

Antibody-dependent cellular cytotoxicity in HIV infection [PDF]

AIDS, 2018
: Interactions between the Fc segment of IgG and its receptors (FcγRs) found on cells such as natural killer cells, monocytes, macrophages and neutrophils can potentially mediate antiviral effects in the setting of HIV and related infections. We review the potential role of FcγR interactions in HIV, SIV and SHIV infections, with an emphasis on antibody-
Forthal, Donald N, Finzi, Andrés
openaire   +4 more sources

Preclinical evaluation of AFM24, a novel CD16A-specific innate immune cell engager targeting EGFR-positive tumors

mAbs, 2021
Epidermal growth factor receptor (EGFR)-targeted cancer therapy such as anti-EGFR monoclonal antibodies and tyrosine kinase inhibitors have demonstrated clinical efficacy.
Susanne Wingert, Uwe Reusch, Stefan Knackmuss, Michael Kluge, Michael Damrat, Jens Pahl, Ute Schniegler-Mattox, Thomas Mueller, Ivica Fucek, Kristina Ellwanger, Michael Tesar, Torsten Haneke, Joachim Koch, Martin Treder, Wolfgang Fischer, Erich Rajkovic   +15 more
doaj   +1 more source