Results 21 to 30 of about 26,161 (209)
The hedging effectiveness of gold against US stocks in a post-financial crisis era
Cogent Economics & Finance, 2019 Purpose—The purpose of this paper is to examine the transmission mechanisms and dynamic spillover effects between gold spot prices and US equity prices following the 2007 Global Financial Crisis.
Najib Shrydeh +3 more
doaj +1 more source
OncoImmunology, 2018 Checkpoint inhibitors targeting the PD-1/PD-L1 axis are promising immunotherapies shown to elicit objective responses against multiple tumor types, yet these agents fail to benefit most patients with carcinomas.
Kristin C. Hicks +12 more
doaj +1 more source
Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients
Signal Transduction and Targeted Therapy, 2021 Antibody-dependent cellular cytotoxicity (ADCC) responses to viral infection are a form of antibody regulated immune responses mediated through the Fc fragment. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered ADCC responses
Yuanling Yu +25 more
doaj +1 more source
CD89-mediated recruitment of macrophages via a bispecific antibody enhances anti-tumor efficacy
OncoImmunology, 2018 Since tumors are often infiltrated by macrophages, it would be advantageous to turn these types of cells into cytotoxic effector cells. Here, we have designed a novel bispecific antibody (BsAb) that targets both tumor antigen (CD20) and the FcαRI ...
Bingyu Li +8 more
doaj +1 more source
Angewandte Chemie, EarlyView.We report a super‐resolution strategy that maps cholesterol‐rich membrane domains in whole, intact cells with an effective spatial resolution of ∼40 nm by combining expansion microscopy with a perfringolysin O domain 4 probe. This approach enables direct visualization of the spatial association between CD20 and CD38 complexes and cholesterol‐rich ...
Gang Wen +9 more
wiley +2 more sources
OncoImmunology, 2019 Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells.
Maria C. Ochoa +15 more
doaj +1 more source
Angewandte Chemie, EarlyView.Combining HDX‐MS and NMR enables the mapping of epitopes and paratopes in full‐length antibody complexes, revealing transient interactions and potential artifacts. ABSTRACT Recombinant biomacromolecules have significantly transformed pharmaceuticals, in particular monoclonal antibodies (mAbs) that target key areas in oncology, immunology, inflammation,
Francesca Sacco +13 more
wiley +2 more sources
Natural killer cels in immunotherapy for cancer
Сибирский онкологический журнал, 2019 Cancer is the second leading cause of death worldwide behind cardiovascular diseases. Late stage of cancer at diagnosis and low efficacy of traditional cancer treatments result in low survival rate in cancer patients.
E. A. Borobova, A. A. Zheravin
doaj +1 more source
ANTIPLATELET THERAPY IN THE PREVENTION OF CEREBROVASCULAR ACCIDENTS
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2017 Currently the problem of preventing cerebrovascular disorders, in which antiplatelet therapy takes one of the leading places, remains relevant. The efficiency of the therapy depends on a large number of modifiable and non-modifiable factors.
O. V. Rodionova +6 more
doaj +1 more source
PLoS Pathogens, 2023 Antibodies specific for diverse epitopes of the simian immunodeficiency virus envelope glycoprotein (SIV Env) have been isolated from rhesus macaques to provide physiologically relevant reagents for investigating antibody-mediated protection in this ...
Michael W Grunst +8 more
doaj +1 more source