Results 11 to 20 of about 580,210 (311)
The Journal of Immunology, 2007 Abstract In this review, we overview the main features and functions of NK cells, focusing on their role in cell-mediated immune response to tumor cells. In parallel, we discuss the information available in the field of NK cell receptors and offer a wide general overview of functional aspects of cell targeting and killing, focusing on ...
Zamai L +7 more
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Evidence-Based Complementary and Alternative Medicine, 2004 It is believed that tumor development, outgrowth and metastasis are under the surveillance of the immune system. Although both innate and acquired immune systems play roles, innate immunity is the spearhead against tumors. Recent studies have revealed the critical role of natural killer (NK) cells in immune surveillance and that NK cell activity is ...
Takeda, Kazuyoshi, Okumura, Ko
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BioMed Research International, 2011 Psoriasis is a chronic condition of the skin characterised by distinctive scaly plaques. The immune system is now thought to play a major role in the development and pathogenesis of psoriasis with immune cells and cytokines influencing keratinocyte function.
Dunphy, Sinéad, Gardiner, Clair M.
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Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells. [PDF]
, 2016 Natural killer (NK) cells are functionally suppressed in the glioblastoma multiforme (GBM) tumor microenvironment. We have recently shown that survival and differentiation of cancer stem-like cells (CSCs)/poorly differentiated tumors are controlled ...
Bui, Vickie T +8 more
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Journal of Leukocyte Biology, 2019 AbstractNatural Killer (NK) cells are important antiviral and anticancer effector cells. They have excellent potential for immunotherapy although impaired functions during cancer limit their effectiveness. The discovery that cellular metabolism can impact on and regulate immune functions has led to an explosion of articles in this new area of ...
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NK cells are not required for spontaneous autoimmune diabetes in NOD mice. [PDF]
PLoS ONE, 2012 NK cells have been shown to either promote or protect from autoimmune diseases. Several studies have examined the role of receptors preferentially expressed by NK cells in the spontaneous disease of NOD mice or the direct role of NK cells in acute ...
Joshua N Beilke +5 more
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Frontiers in Immunology, 2017 Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells.
Jiacheng Bi, Zhigang Tian, Zhigang Tian
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The mechanobiology of NK cells- ‘Forcing NK to Sense’ target cells
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2023 Natural killer (NK) cells are innate immune lymphocytes that recognize and kill cancer and infected cells, which makes them unique 'off-the-shelf' candidates for a new generation of immunotherapies. Biomechanical forces in homeostasis and pathophysiology accrue additional immune regulation for NK immune responses.
Wong, Darren Chen Pei, Ding, Jeak Ling
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Tumor-priming converts NK cells to memory-like NK cells
OncoImmunology, 2017 Fascinating earlier evidence suggests an intrinsic capacity of human natural killer (NK) cells to acquire adaptive immune features in the context of cytomegalovirus (CMV) infection or pro-inflammatory cytokine stimulation.
Marina Pal +10 more
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Frontiers in Immunology, 2023 Natural killer (NK) cells are cellular components of the innate immune system that can recognize and suppress the proliferation of cancer cells. NK cells can eliminate cancer cells through direct lysis, by secreting perforin and granzymes, or through ...
Massimo Fantini +2 more
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