Results 41 to 50 of about 291,920 (218)

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The Role of NK Cells in Cancer Immunotherapy: Mechanisms, Evasion Strategies, and Therapeutic Advances

Biomedicines
Background/Objectives: Natural killer (NK) cells play a crucial role in tumor surveillance by exerting cytotoxic activity and modulating immune responses. However, tumors employ diverse evasion strategies that limit NK cell effectiveness.
Paula Morcillo-Martín-Romo, Javier Valverde-Pozo, María Ortiz-Bueno, Maurizio Arnone, Laura Espinar-Barranco, Celia Espinar-Barranco, María Eugenia García-Rubiño   +6 more
doaj   +1 more source

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation

Frontiers in Immunology, 2019
Natural killer (NK) cells can produce IFNγ or IL-10 to regulate inflammation and immune responses but the factors driving NK cell IL-10 secretion are poorly-defined.
Sarah E. Clark, Kristina S. Burrack, Stephen C. Jameson, Sara E. Hamilton, Laurel L. Lenz   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Feeder cell training shapes the phenotype and function of in vitro expanded natural killer cells

MedComm
Natural killer (NK) cells are candidates for adoptive cell therapy, and the protocols for their activation and expansion profoundly influence their function and fate.
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Loïs Coënon, Caroline Multrier, Loïc Vaillant, Julien Peyroux, Tianxiang Zhang, Martin Villalba   +8 more
doaj   +1 more source

Molecular Regulation of NK Cell Maturation

Frontiers in Immunology, 2020
Natural killer (NK) cells are innate lymphocytes specialized in immune surveillance against tumors and infections. To reach their optimal functional status, NK cells must undergo a process of maturation from immature to mature NK cells.
Jiacheng Bi, Xuefu Wang
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Latent cytomegalovirus disrupts innate NK cell responses to P. falciparum and impairs parasite control in first infection in adults.

PLoS Pathogens
NK cells are innate and adaptive responders to malaria, with functional responses underpinned by NK cell heterogeneity. One driver of NK cell heterogeneity is latent CMV infection. Latent CMV infection negatively impacts adaptive immunity to malaria, but
Reena Mukhiya, Jessica R Loughland, Nicholas L Dooley, Zuleima Pava, Damian A Oyong, Dean W Andrew, Julianne Hamelink, Kiana Berry, James S McCarthy, Bridget E Barber, J Alejandro Lopez, Christian R Engwerda, Michelle J Boyle   +12 more
doaj   +1 more source

A novel NKp80-based strategy for universal identification of normal, reactive and tumor/clonal natural killer-cells in blood

Frontiers in Immunology
PurposeNatural killer (NK) cells are traditionally identified by flow cytometry using a combination of markers (CD16/CD56/CD3), because a specific NK-cell marker is still missing.
F. Javier Morán-Plata, F. Javier Morán-Plata, Noemí Muñoz-García, Noemí Muñoz-García, María González-González, María González-González, Julio Pozo, Julio Pozo, Sonia Carretero-Domínguez, Sonia Carretero-Domínguez, Sonia Carretero-Domínguez, Sheila Mateos, Sheila Mateos, Susana Barrena, Susana Barrena, Moncef Belhassen-García, Moncef Belhassen-García, Catarina Lau, Maria Dos Anjos Teixeira, Ana Helena Santos, Ana Yeguas, Ana Balanzategui, Ana Balanzategui, Alejandro Martín García-Sancho, Alejandro Martín García-Sancho, Alejandro Martín García-Sancho, Alejandro Martín García-Sancho, Alberto Orfao, Alberto Orfao, Alberto Orfao, Alberto Orfao, Julia Almeida, Julia Almeida, Julia Almeida, Julia Almeida   +34 more
doaj   +1 more source