Results 21 to 30 of about 464,635 (262)

Maintaining the Balance: Regulation of NK Cell Activity

Cells
Natural Killer (NK) cells, integral components of the innate immune system, play a crucial role in the protection against intracellular threats. Their cytotoxic power requires that activation is tightly controlled, and in this, they take a unique ...
Vanna Imširović, Felix M. Wensveen, Bojan Polić, Vedrana Jelenčić   +3 more
doaj   +1 more source

Chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulation in rats

Molecular Pain, 2017
Background Preclinical experimental studies revealed an acute alteration of pituitary adenylate cyclase-activating polypeptide in response to a single activation of the trigeminovascular system, which suggests a potential role of pituitary adenylate ...
Xun Han, Ye Ran, Min Su, Yinglu Liu, Wenjing Tang, Zhao Dong, Shengyuan Yu   +6 more
doaj   +1 more source

Protease-Activated Receptors

, 2003
Publisher Summary Distinct proteases—best exemplified by serine proteases such as thrombin—are potent cellular activators. Many of these cellular effects are mediated by a group of seven transmembrane G-protein-coupled receptors, uniquely activated by proteolytic cleavage [protease-activated receptors (PARs)].
openaire   +4 more sources

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

New GABA amides activating GABAA-receptors

Beilstein Journal of Organic Chemistry, 2013
We have prepared a series of new and some literature-reported GABA-amides and determined their effect on the activation of GABAA-receptors expressed in CHO cells.
Peter Raster, Andreas Späth, Svetlana Bultakova, Pau Gorostiza, Burkhard König, Piotr Bregestovski   +5 more
doaj   +1 more source

Novel identified receptors on mast cells

Frontiers in Immunology, 2012
Mast cells (MC) are major participants in the allergic reaction. In addition they possess immunomodulatory roles in the innate and adaptive immune reactions.
Helena eMigalovich-Sheikhet, Sheli eFriedman, David eMankuta, Francesca eLevi-Schaffer   +3 more
doaj   +1 more source

Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity

mBio, 2023
HIV-1 evades antibody-dependent cellular cytotoxicity (ADCC) responses not only by controlling Env conformation and quantity at the cell surface but also by altering NK cell activation via the downmodulation of several ligands of activating and co ...
Lorie Marchitto, Mehdi Benlarbi, Jérémie Prévost, Annemarie Laumaea, Jade Descôteaux-Dinelle, Halima Medjahed, Catherine Bourassa, Gabrielle Gendron-Lepage, Frank Kirchhoff, Daniel Sauter, Beatrice H. Hahn, Andrés Finzi, Jonathan Richard   +12 more
doaj   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

The Glutathione Metabolite γ-Glutamyl-Glutamate Partially Activates Glutamate NMDA Receptors in Central Neurons With Higher Efficacy for GluN2B-Containing Receptors

Frontiers in Pharmacology, 2022
Gamma-L-glutamyl-L-glutamate (γ-Glu-Glu) was synthetized and further characterized for its activity on cultured neurons. We observed that γ-Glu-Glu elicited excitatory effects on neurons likely by activating mainly the N-methyl-D-aspartate (NMDA ...
Fatiha Sebih, Nawfel Mokrane, Pierre Fontanel, Mete Kayatekin, Mahira Kaabeche, Janique Guiramand, Catherine Cohen-Solal, Thierry Cens, Matthieu Rousset, Pierre Charnet, Marie-Céleste De Jésus Ferreira, Jean-Baptiste Thibaud, Claudine Ménard, Sonia Cantel, Valérie Rolland, Michel Vignes, Julien Roussel   +16 more
doaj   +1 more source