Results 1 to 10 of about 21,131 (181)
NKG2D/NKG2-Ligand Pathway Offers New Opportunities in Cancer Treatment
Frontiers in Immunology, 2019 The antitumor functions of NK cells are regulated by the integration of positive and negative signals triggered by numerous membrane receptors present on the NK cells themselves.
Anne Caignard +2 more
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NKG2D: A Master Regulator of Immune Cell Responsiveness
Frontiers in Immunology, 2018 NKG2D is an activating receptor that is mostly expressed on cells of the cytotoxic arm of the immune system. Ligands of NKG2D are normally of low abundance, but can be induced in virtually any cell in response to stressors, such as infection and ...
Vedrana Jelencic +2 more
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NKG2D and Its Ligands: “One for All, All for One”
Frontiers in Immunology, 2018 The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with ...
Alessandra Soriani +2 more
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Interaction between NKG2D and its ligands MICA/B activates the DAP12/SYK/p53/p21 axis to drive pulmonary fibrosis [PDF]
Frontiers in ImmunologyBackgroundPulmonary fibrosis (PF) is a progressive, fatal interstitial lung disease with limited therapeutic options. Emerging evidence implicates immune–fibrotic crosstalk in PF pathogenesis, although the underlying molecular mechanisms remain poorly ...
Caiping Zhao +12 more
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The Paradoxical Role of NKG2D in Cancer Immunity
Frontiers in Immunology, 2018 The activating receptor NKG2D and its ligands are recognized as a potent immune axis that controls tumor growth and microbial infections. With regards to cancer surveillance, various studies have demonstrated the antitumor function mediated by NKG2D on ...
Nadia Guerra +2 more
exaly +3 more sources
Expression of NKG2D Receptors in CD3+ and CD56+ Cells in Blood Samples of Pre-eclampsia Patients and the Effect of Silymarin on Their Activity in Vitro [PDF]
مجله دانشکده پزشکی اصفهان, 2022 Background: Increased NK cells or their cytokine activity in endometrium and peripheral blood of mothers with pre-eclampsia have been reported. NKG2D is a cell surface receptor that can be used to detect NK cell and lymphocytic activity. Plant flavonoids
Ali Reza Andalib +5 more
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Клиническая онкогематология, 2021 NK-cells as innate immunity elements manifest key reactions of antitumor immune response. NKG2D is an activating transmembrane receptor of NK-cells which is responsible for cytotoxicity initiation in response to the binding of specific ligands of ...
Kseniya Aleksandrovna Levchuk +5 more
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Recent Advances in Molecular Mechanisms of the NKG2D Pathway in Hepatocellular Carcinoma
Biomolecules, 2020 Hepatocellular carcinoma is a common malignant tumor with high mortality. Its malignant proliferation, invasion, and metastasis are closely related to the cellular immune function of the patients.
Jian Wang, Cun-Di Li, Lin Sun
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Frontiers in Immunology, 2021 The activating immune receptor natural killer group member D (NKG2D) and its cognate ligands represent a fundamental surveillance system of cellular distress, damage or transformation.
Eric Alves +11 more
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OncoImmunology, 2022 NK group 2, member D (NKG2D) is one of the most critical activating receptors expressed by natural killer (NK) cells. There is growing evidence that acute myeloid leukemia (AML) cells may evade NK cell-mediated cell lysis by expressing low or no ligands ...
Meng Liu +12 more
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