Results 31 to 40 of about 22,145 (200)

NKG2D/NKG2-Ligand Pathway Offers New Opportunities in Cancer Treatment

Frontiers in Immunology, 2019
The antitumor functions of NK cells are regulated by the integration of positive and negative signals triggered by numerous membrane receptors present on the NK cells themselves.
Alexandra Frazao, Louise Rethacker, Meriem Messaoudene, Meriem Messaoudene, Marie-Françoise Avril, Marie-Françoise Avril, Antoine Toubert, Antoine Toubert, Antoine Toubert, Nicolas Dulphy, Nicolas Dulphy, Nicolas Dulphy, Anne Caignard   +12 more
doaj   +1 more source

The killing effect of Tanshinol on breast cancer cells: insight into the reversion of TGF-β1-mediated suppression of NK cell functions

Frontiers in Bioscience-Landmark, 2021
Background: Natural killer (NK) cells play an indispensable role in anti-tumor immunity. TGF-β1 is the main accomplice of tumor immune escape, inhibiting tumor immunity mediated by NK cells.
Chunmei Yang, Cheng Qian, Tingting Zhang, Weiwei Zheng, Shan Zhang, Shijun Wang, Aiyun Wang, Yang Zhao, Yin Lu   +8 more
doaj   +1 more source

Control of Tumor Initiation by NKG2D Naturally Expressed on Ovarian Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2017
Cancer cells may co-opt the NKG2D lymphocyte receptor to complement the presence of its ligands for autonomous stimulation of oncogenic signaling. Previous studies raise the possibility that cancer cell NKG2D may induce high malignancy traits, but its ...
Xin Cai, Andrea Caballero-Benitez, Mesfin M. Gewe, Isaac C. Jenkins, Charles W. Drescher, Roland K. Strong, Thomas Spies, Veronika Groh   +7 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

NKG2D and Its Ligands: “One for All, All for One”

Frontiers in Immunology, 2018
The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with ...
Alessandra Zingoni, Rosa Molfetta, Cinzia Fionda, Alessandra Soriani, Rossella Paolini, Marco Cippitelli, Cristina Cerboni, Angela Santoni   +7 more
doaj   +1 more source

How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation [PDF]

Frontiers in Immunology, 2017
Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions. Stressed and damaged cells need to be cleared to control local inflammation and trigger tissue healing.
Fabrizio Antonangeli, Alessandra Soriani, Cristina Cerboni, Giuseppe Sciumè, Angela Santoni, Angela Santoni   +5 more
openaire   +4 more sources

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

Differential Effects of Histone Deacetylases on the Expression of NKG2D Ligands and NK Cell-Mediated Anticancer Immunity in Lung Cancer Cells

Molecules, 2021
Histone acetylation is an epigenetic mechanism that regulates the expression of various genes, such as natural killer group 2, member D (NKG2D) ligands.
Haeryung Cho, Woo-Chang Son, Young-Shin Lee, Eun Jung Youn, Chi-Dug Kang, You-Soo Park, Jaeho Bae   +6 more
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

A Truncated Human NKG2D Splice Isoform Negatively Regulates NKG2D-Mediated Function [PDF]

The Journal of Immunology, 2014
Abstract Natural killer group 2, member D (NKG2D) is a stimulatory receptor expressed by NK cells and a subset of T cells. NKG2D is crucial in diverse aspects of innate and adaptive immune functions. In this study, we characterize a novel splice variant of human NKG2D that encodes a truncated receptor lacking the ligand-binding ...
Mobin A, Karimi, Oscar, Aguilar, Baixiang, Zou, Michael H, Bachmann, James R, Carlyle, Cynthia L, Baldwin, Taku, Kambayashi   +6 more
openaire   +2 more sources