Results 21 to 30 of about 21,131 (181)
Haematologica, 2012 Background NKG2D is an activating receptor expressed by natural killer and T cells, which have crucial functions in tumor and microbial immunosurveillance. Several cytokines have been identified as modulators of NKG2D receptor expression. However, little
J. Luis Espinoza +6 more
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NKG2D Ligands Expression and NKG2D-Mediated NK Activity in Sezary Patients [PDF]
Journal of Investigative Dermatology, 2009 Sezary syndrome (SS) is a rare lymphoma characterized by the clonal expansion in the skin and in blood of CD4(+)CD158k(+) T cells. Natural killer (NK) activation against tumors in leukemia models is partly based on the recognition of the target through the NKG2D/NKG2D ligands interactions. We analyzed ex vivo SS malignant lymphocytes for the expression
Dulphy, Nicolas +5 more
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Harnessing innate lung anti-cancer effector functions with a novel bacterial-derived immunotherapy
OncoImmunology, 2018 Acute infection is known to induce strong anti-tumor immune responses, but clinical translation has been hindered by the lack of an effective strategy to safely and consistently provoke a therapeutic response.
Mark Bazett +13 more
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CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation. [PDF]
PLoS ONE, 2013 Migration of encephalitogenic CD4(+) T lymphocytes across the blood-brain barrier is an essential step in the pathogenesis of multiple sclerosis (MS). We here demonstrate that expression of the co-stimulatory receptor NKG2D defines a subpopulation of CD4(
Tobias Ruck +14 more
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Journal of Hepatocellular Carcinoma, 2022 Reham Hammad,1 Mona A Eldosoky,1 Alshaimaa M Mosaad,2 Asmaa M El-Nasser,3 Fatma M Kotb,4 Salwa I Elshennawy,1 Noha Abdel-Rahman Eldesoky,5 Mohamed A Selim,6 Gina G Naguib,7 Ossama A Ahmed,7 Mohamed Alboraie,8 Reda Badr Aglan9 1Clinical Pathology ...
Hammad R +11 more
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OncoImmunology, 2018 Human γδT cell immunotherapy is well tolerated and has shown promising results in clinical trials; however, its antitumor efficacy is limited, including results in solid tumors.
Teruki Shimizu +4 more
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The mIRNA519a-3p and NKG2D in endometriosis.
Indonesian Journal of Obstetrics and Gynecology, 2022 Background: Natural killer (NK) cells play a role in pathogenesis of endometriosis. Lower expressions of NK cells receptor group 2D (NKG2D) ligands inhibits cytotoxic activity of NK cells; a common immunity avoidance mechanism in neoplasms. Literatures have proven miRNAs regulatory effect on NKG2D expression.
Cepi Teguh Pramayadi +3 more
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The Role of NKG2D in Vitiligo [PDF]
Frontiers in Immunology, 2021 Vitiligo is an acquired multifactorial disease that affects melanocytes and results in skin depigmentation. In this review, we examine the role of cells stress and self-reactive T cells responses. Given the canonical and non-canonical functions of NKG2D, such as authenticating stressed target and enhance TCR signaling, we examine how melanocyte stress ...
Lourdes Plaza-Rojas +1 more
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NKG2D and its ligands in cancer [PDF]
Current Opinion in Immunology, 2018 NKG2D is an activating immune receptor expressed by NK and effector T cells. Induced expression of NKG2D ligand on tumor cell surface during oncogenic insults renders cancer cells susceptible to immune destruction. In advanced human cancers, tumor cells shed NKG2D ligand to produce an immune soluble form as a means of immune evasion.
Payal Dhar, Jennifer D Wu
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Molecules, 2021 Histone acetylation is an epigenetic mechanism that regulates the expression of various genes, such as natural killer group 2, member D (NKG2D) ligands.
Haeryung Cho +6 more
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