Results 21 to 30 of about 22,145 (200)

Harnessing innate lung anti-cancer effector functions with a novel bacterial-derived immunotherapy

OncoImmunology, 2018
Acute infection is known to induce strong anti-tumor immune responses, but clinical translation has been hindered by the lack of an effective strategy to safely and consistently provoke a therapeutic response.
Mark Bazett, Amanda M. Costa, Momir Bosiljcic, Rebecca M. Anderson, Matthew P. Alexander, Stephanie W. Y. Wong, Salim Dhanji, Jenny MH Chen, Jim Pankovich, Stephen Lam, Simon Sutcliffe, Hal Gunn, Shirin Kalyan, David W. Mullins   +13 more
doaj   +1 more source

Natural Killer Group 2D Receptor and B1a Cells Crosstalk in Post-Hepatitis C Virus Infection Hepatocellular Carcinoma and Cirrhosis

Journal of Hepatocellular Carcinoma, 2022
Reham Hammad,1 Mona A Eldosoky,1 Alshaimaa M Mosaad,2 Asmaa M El-Nasser,3 Fatma M Kotb,4 Salwa I Elshennawy,1 Noha Abdel-Rahman Eldesoky,5 Mohamed A Selim,6 Gina G Naguib,7 Ossama A Ahmed,7 Mohamed Alboraie,8 Reda Badr Aglan9 1Clinical Pathology ...
Hammad R, Eldosoky MA, Mosaad AM, El-Nasser AM, Kotb FM, Elshennawy SI, Eldesoky NAR, Selim MA, Naguib GG, Ahmed OA, Alboraie M, Aglan RB   +11 more
doaj  

CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation. [PDF]

PLoS ONE, 2013
Migration of encephalitogenic CD4(+) T lymphocytes across the blood-brain barrier is an essential step in the pathogenesis of multiple sclerosis (MS). We here demonstrate that expression of the co-stimulatory receptor NKG2D defines a subpopulation of CD4(
Tobias Ruck, Stefan Bittner, Catharina C Gross, Johanna Breuer, Stefanie Albrecht, Sabrina Korr, Kerstin Göbel, Susann Pankratz, Christian M Henschel, Nicholas Schwab, Ori Staszewski, Marco Prinz, Tanja Kuhlmann, Sven G Meuth, Heinz Wiendl   +14 more
doaj   +1 more source

The mIRNA519a-3p and NKG2D in endometriosis.

Indonesian Journal of Obstetrics and Gynecology, 2022
Background: Natural killer (NK) cells play a role in pathogenesis of endometriosis. Lower expressions of NK cells receptor group 2D (NKG2D) ligands inhibits cytotoxic activity of NK cells; a common immunity avoidance mechanism in neoplasms. Literatures have proven miRNAs regulatory effect on NKG2D expression.
Cepi Teguh Pramayadi, Muharam Natadisastra, Kanadi Sumapradja, Aria Kekalih   +3 more
openaire   +2 more sources

Low dose gemcitabine increases the cytotoxicity of human Vγ9Vδ2 T cells in bladder cancer cells in vitro and in an orthotopic xenograft model

OncoImmunology, 2018
Human γδT cell immunotherapy is well tolerated and has shown promising results in clinical trials; however, its antitumor efficacy is limited, including results in solid tumors.
Teruki Shimizu, Mako Tomogane, Masatsugu Miyashita, Osamu Ukimura, Eishi Ashihara   +4 more
doaj   +1 more source

Human microRNA-1245 down-regulates the NKG2D receptor in natural killer cells and impairs NKG2D-mediated functions

Haematologica, 2012
Background NKG2D is an activating receptor expressed by natural killer and T cells, which have crucial functions in tumor and microbial immunosurveillance. Several cytokines have been identified as modulators of NKG2D receptor expression. However, little
J. Luis Espinoza, Akiyoshi Takami, Katsuji Yoshioka, Katsuya Nakata, Tokiharu Sato, Yoshihito Kasahara, Shinji Nakao   +6 more
doaj   +1 more source

Stress-induced MICA and MICB molecules in oncology

Медицинская иммунология, 2022
MICA and MICB molecules, MHC class I chain-related proteins, are expressed on the membranes of damaged, transformed or infected cells. These glycoproteins bind to the NKG2D receptor of NK cells, resulting in their activation and cytotoxic response ...
S. A. Yurevna, I. V. Smirnov, M. P. Samoylovich   +2 more
doaj   +1 more source

NKG2D signaling in cancer immunosurveillance [PDF]

International Journal of Cancer, 2014
The immune system is able to detect and eliminate transformed cells. The activating receptor NKG2D is particularly relevant for cancer immunosurveillance. NKG2D ligand expression renders tumor cells more susceptible to be killed by NK and T cells, and correlates with the clinical outcome of the disease.
Alejandro, López-Soto, Leticia, Huergo-Zapico, Andrea, Acebes-Huerta, Mónica, Villa-Alvarez, Segundo, Gonzalez   +4 more
openaire   +2 more sources

NKG2D and its ligands in cancer [PDF]

Current Opinion in Immunology, 2018
NKG2D is an activating immune receptor expressed by NK and effector T cells. Induced expression of NKG2D ligand on tumor cell surface during oncogenic insults renders cancer cells susceptible to immune destruction. In advanced human cancers, tumor cells shed NKG2D ligand to produce an immune soluble form as a means of immune evasion.
Payal Dhar, Jennifer D Wu
openaire   +2 more sources

Soluble NKG2D ligands in the ovarian cancer microenvironment are associated with an adverse clinical outcome and decreased memory effector T cells independent of NKG2D downregulation

OncoImmunology, 2017
The immune receptor NKG2D is predominantly expressed on NK cells and T cell subsets and confers anti-tumor activity. According to the current paradigm, immune surveillance is counteracted by soluble ligands shed into the microenvironment, which down ...
Maulik Vyas, Silke Reinartz, Nathalie Hoffmann, Katrin S. Reiners, Sonja Lieber, Julia M. Jansen, Uwe Wagner, Rolf Müller, Elke Pogge von Strandmann   +8 more
doaj   +1 more source