Results 1 to 10 of about 381,426 (191)

MAPK inhibitors dynamically affect melanoma release of immune NKG2D-ligands, as soluble protein and extracellular vesicle-associated [PDF]

Frontiers in Cell and Developmental Biology, 2023
Metastatic melanoma presents, in many cases, oncogenic mutations in BRAF, a MAPK involved in proliferation of tumour cells. BRAF inhibitors, used as therapy in patients with these mutations, often lead to tumour resistance and, thus, the use of MEK ...
Silvia López-Borrego, Carmen Campos-Silva, Amaia Sandúa, Tamara Camino, Lucía Téllez-Pérez, Estibaliz Alegre, Alexandra Beneitez, Ricardo Jara-Acevedo, Annette Paschen, María Pardo, Álvaro González, Mar Valés-Gómez   +11 more
doaj   +6 more sources

Differential Effects of Histone Deacetylases on the Expression of NKG2D Ligands and NK Cell-Mediated Anticancer Immunity in Lung Cancer Cells [PDF]

Molecules, 2021
Histone acetylation is an epigenetic mechanism that regulates the expression of various genes, such as natural killer group 2, member D (NKG2D) ligands.
Haeryung Cho, Woo-Chang Son, Young-Shin Lee, Eun Jung Youn, Chi-Dug Kang, You-Soo Park, Jaeho Bae   +6 more
doaj   +4 more sources

Chimeric Antigen Receptor T Cells Targeting NKG2D-Ligands Show Robust Efficacy Against Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia [PDF]

Frontiers in Immunology, 2020
CAR T cell approaches to effectively target AML and T-ALL without off-tumor effects on healthy myeloid or T cell compartments respectively are an unmet medical need.
Lina Driouk, Joanina K. Gicobi, Yusuke Kamihara, Kayleigh Rutherford, Glenn Dranoff, Jerome Ritz, Jerome Ritz, Susanne H. C. Baumeister, Susanne H. C. Baumeister, Susanne H. C. Baumeister, Susanne H. C. Baumeister   +10 more
doaj   +4 more sources

Upregulation of NKG2D ligands impairs hematopoietic stem cell function in Fanconi anemia [PDF]

The Journal of Clinical Investigation, 2022
Fanconi anemia (FA) is the most prevalent inherited bone marrow failure (BMF) syndrome. Nevertheless, the pathophysiological mechanisms of BMF in FA have not been fully elucidated.
José A. Casado, Antonio Valeri, Rebeca Sanchez-Domínguez, Paula Vela, Andrea López, Susana Navarro, Omaira Alberquilla, Helmut Hanenberg, Roser Pujol, José-Carlos Segovia, Jordi Minguillón, Jordi Surrallés, Cristina Díaz de Heredia, Julián Sevilla, Paula Rio, Juan A. Bueren   +15 more
doaj   +5 more sources

A signature based on NKG2D ligands to predict the recurrence of hepatocellular carcinoma after radical resection [PDF]

Cancer Medicine, 2023
Introduction Due to the high recurrence, the HCC prognosis remains poor. Yet, the biomarkers for predicting the recurrence of high‐risk patients are currently lacking.
Dongbo Chen, Jie Gao, Liying Ren, Pu Chen, Yao Yang, Shaoping She, Yong Xie, Weijia Liao, Hongsong Chen   +8 more
doaj   +2 more sources

The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition [PDF]

Frontiers in Immunology, 2021
The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on ...
Abigael Eva Chaouat, Barbara Seliger, Barbara Seliger, Ofer Mandelboim, Dominik Schmiedel, Dominik Schmiedel   +5 more
doaj   +2 more sources

Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality [PDF]

Frontiers in Immunology, 2023
In recent years, reoviruses have been of major interest in immunotherapy because of their oncolytic properties. Preclinical and clinical trials, in which reovirus was used for the treatment of melanoma and glioblastoma, have paved the way for future ...
Raghad Khaleafi, Jelena Zeleznjak, Sapir Cordela, Shani Drucker, Tihana Lenac Rovis, Stipan Jonjic, Yotam Bar-On   +6 more
doaj   +2 more sources

cGAS/STING-mediated upregulation of NKG2D ligands in LSCs contributes to enhanced sensitivity to NK cells [PDF]

Frontiers in Oncology
IntroductionNatural killer (NK) cells-mediated immune surveillance is essential role for tumor recognition and elimination. The binding of NK group 2 member D (NKG2D) ligands to NKG2D receptor is sufficient to activate the NK cells' cytotoxicity against ...
Yan Ouyang, Yilin Qin, Qianmin Zhang, Pengcheng Zhu, Huifang Zhu, Huifang Zhu, Huifang Zhu, Huifang Zhu   +7 more
doaj   +2 more sources

NKG2D Ligands–Critical Targets for Cancer Immune Escape and Therapy [PDF]

Frontiers in Immunology, 2018
DNA damage, oncogene activation and excessive proliferation, chromatin modulations or oxidative stress are all important hallmarks of cancer. Interestingly, all of these abnormalities also induce a cellular stress response.
Dominik Schmiedel, Ofer Mandelboim
doaj   +2 more sources

Combinatorial therapy with resveratrol sensitizes glioblastoma to NKG2D CAR-T cells [PDF]

Frontiers in Immunology
Chimeric antigen receptor T-cell (CAR-T) therapies have shown potential in clinical trials for glioblastoma, yet treatment responses vary due to heterogeneous antigen expression and post-treatment immune escape.
Wei Liang, Wei Liang, Yexiao Tang, Muhammad Auwal Saliu, Muhammad Auwal Saliu, Mansur Dabai Salisu, Mansur Dabai Salisu, Cuimei Chen, Zhiming Xu, Shu Xu, Maoxuan Liu, Maoxuan Liu, Xiaochun Wan, Xiaochun Wan   +13 more
doaj   +2 more sources