NKG2D ligands in tumor immunity [PDF]
Oncogene, 2008 The activating receptor NKG2D (natural-killer group 2, member D) and its ligands play an important role in the NK, gammadelta(+) and CD8(+) T-cell-mediated immune response to tumors. Ligands for NKG2D are rarely detectable on the surface of healthy cells and tissues, but are frequently expressed by tumor cell lines and in tumor tissues.
N, Nausch, A, Cerwenka
openaire +2 more sources
NKG2D and its ligands in cancer [PDF]
Current Opinion in Immunology, 2018 NKG2D is an activating immune receptor expressed by NK and effector T cells. Induced expression of NKG2D ligand on tumor cell surface during oncogenic insults renders cancer cells susceptible to immune destruction. In advanced human cancers, tumor cells shed NKG2D ligand to produce an immune soluble form as a means of immune evasion.
Payal Dhar, Jennifer D Wu
openaire +2 more sources
Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands. [PDF]
PLoS Pathogens, 2010 The activating immunoreceptor NKG2D promotes elimination of infected or malignant cells by cytotoxic lymphocytes through engagement of stress-induced MHC class I-related ligands.
Steffen Müller +3 more
doaj +1 more source
Cutting an NKG2D Ligand Short: Cellular Processing of the Peculiar Human NKG2D Ligand ULBP4 [PDF]
Frontiers in Immunology, 2018 Stress-induced cell surface expression of MHC class I-related glycoproteins of the MIC and ULBP families allows for immune recognition of dangerous "self cells" by human cytotoxic lymphocytes via the NKG2D receptor. With two MIC molecules (MICA and MICB) and six ULBP molecules (ULBP1-6), there are a total of eight human NKG2D ligands (NKG2DL).
Tobias Zöller +4 more
openaire +4 more sources
More than Decoration: Roles for Natural Killer Group 2 Member D Ligand Expression by Immune Cells
Frontiers in Immunology, 2018 The activating immune receptor natural killer group 2 member D (NKG2D), which is expressed by natural killer cells and T cell subsets, recognizes a number of ligands expressed by “stressed” or damaged cells.
Andrew P. Trembath, Mary A. Markiewicz
doaj +1 more source
Human Cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against NK cell cytotoxicity. [PDF]
, 2003 The activating receptor, NKG2D, is expressed on a variety of immune effector cells and recognizes divergent families of major histocompatibility complex (MHC) class I-related ligands, including the MIC and ULBP proteins.
Sutherland, CL +13 more
core +1 more source
Modulation of NKG2D expression in human CD8(+) T cells corresponding with tuberculosis drug cure. [PDF]
, 2012 BACKGROUND: Biomarkers predicting tuberculosis treatment response and cure would facilitate drug development. This study investigated expression patterns of the co-stimulation molecule NKG2D in human tuberculosis and treatment to determine its potential ...
Syeda S Hassan +21 more
core +1 more source
NKG2D Ligands in Liquid Biopsy: The Importance of Soluble and Vesicle-Bound Proteins for Immune Modulation [PDF]
, 2022 : The identification of biomarkers allowing diagnostics, prognostics and patient classification is still a chal lenge in oncological research for patient management.
Esteso, Gloria +4 more
core +1 more source
An integrated view of the regulation of NKG2D ligands [PDF]
Immunology, 2009 SummaryNKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T‐cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the emphasis on post ...
Noam, Stern-Ginossar, Ofer, Mandelboim
openaire +2 more sources
Regulation of Ligands for the NKG2D Activating Receptor [PDF]
Annual Review of Immunology, 2013 NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves as a major recognition receptor for detection and elimination of transformed and infected cells and participates in the genesis of several inflammatory diseases.
David H, Raulet +4 more
openaire +2 more sources