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A Concise Review of the Role of the NKG2D Receptor and Its Ligands in Cancer
ImmunoThe immune system’s ability to detect and eliminate transformed cells is a critical factor in suppressing cancer development. However, immune surveillance in tumors is often disrupted by various immune escape mechanisms, many of which remain poorly ...
Velizar Shivarov +2 more
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The Role and Regulation of the NKG2D/NKG2D Ligand System in Cancer [PDF]
Biology, 2023 The family of human NKG2D ligands (NKG2DL) consists of eight stress-induced molecules. Over 80% of human cancers express these ligands on the surface of tumour cells and/or associated stromal elements. In mice, NKG2D deficiency increases susceptibility to some types of cancer, implicating this system in immune surveillance for malignancy.
Ge Tan, Katelyn M. Spillane, John Maher
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The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases [PDF]
Frontiers in Molecular NeuroscienceAdam Stepien, Szymański Piotr
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The mIRNA519a-3p and NKG2D in endometriosis.
Indonesian Journal of Obstetrics and Gynecology, 2022 Background: Natural killer (NK) cells play a role in pathogenesis of endometriosis. Lower expressions of NK cells receptor group 2D (NKG2D) ligands inhibits cytotoxic activity of NK cells; a common immunity avoidance mechanism in neoplasms.
Cepi Teguh Pramayadi +3 more
doaj +1 more source
Journal of Hepatology, 2021 BACKGROUND /Aims: The NKG2D system is a potent immunosurveillance mechanism in cancer based on recognition of the NKG2D ligands expressed on tumour cells by activating receptor natural killer group 2, member D (NKG2D) on immune cells.
Mathilde Cadoux +14 more
semanticscholar +1 more source
NKG2D and its ligands in cancer [PDF]
Current Opinion in Immunology, 2018 NKG2D is an activating immune receptor expressed by NK and effector T cells. Induced expression of NKG2D ligand on tumor cell surface during oncogenic insults renders cancer cells susceptible to immune destruction. In advanced human cancers, tumor cells shed NKG2D ligand to produce an immune soluble form as a means of immune evasion.
Payal Dhar, Jennifer D Wu
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Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands. [PDF]
PLoS Pathogens, 2010 The activating immunoreceptor NKG2D promotes elimination of infected or malignant cells by cytotoxic lymphocytes through engagement of stress-induced MHC class I-related ligands.
Steffen Müller +3 more
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Cutting an NKG2D Ligand Short: Cellular Processing of the Peculiar Human NKG2D Ligand ULBP4 [PDF]
Frontiers in Immunology, 2018 Stress-induced cell surface expression of MHC class I-related glycoproteins of the MIC and ULBP families allows for immune recognition of dangerous "self cells" by human cytotoxic lymphocytes via the NKG2D receptor. With two MIC molecules (MICA and MICB) and six ULBP molecules (ULBP1-6), there are a total of eight human NKG2D ligands (NKG2DL).
Tobias Zöller +4 more
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More than Decoration: Roles for Natural Killer Group 2 Member D Ligand Expression by Immune Cells
Frontiers in Immunology, 2018 The activating immune receptor natural killer group 2 member D (NKG2D), which is expressed by natural killer cells and T cell subsets, recognizes a number of ligands expressed by “stressed” or damaged cells.
Andrew P. Trembath, Mary A. Markiewicz
doaj +1 more source
Regulation of Ligands for the NKG2D Activating Receptor [PDF]
Annual Review of Immunology, 2013 NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves as a major recognition receptor for detection and elimination of transformed and infected cells and participates in the genesis of several inflammatory diseases.
David H, Raulet +4 more
openaire +2 more sources