Mutation hot spots in MICA/MICB extracellular domains [PDF]
Медицинская иммунология, 2023 MICA and MICB are non-classical MHC molecules that indicate cellular stress. They act as ligands for NKG2D receptors found on NK cells, thereby triggering a cytotoxic response against damaged, infected, or transformed cells.
A. Yu. Stolbovaya, I. V. Smirnov
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An integrative framework combining Mendelian randomization, single-cell profiling, and experimental validation identifies FTMT as a mitochondrial–immune regulator in non-small cell lung cancer [PDF]
Cancer Cell InternationalBackground Mitochondrial iron handling and immune surveillance are intertwined in tumor biology. Mitochondrial ferritin (FTMT) buffers redox-active iron in mitochondria, while MICB is an NKG2D ligand that can promote anti-tumor cytotoxicity when ...
Shouyong Xiao +8 more
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Multi-omics analysis reveals MICB promotes cerebral atherosclerosis through FTMT suppression in NK and plasma cells [PDF]
Clinical EpigeneticsBackground Ferroptosis, an iron-dependent form of regulated cell death, is implicated in vascular injury, but how immune-related proteins modulate ferroptosis and cerebral atherosclerosis (CeA) remains unclear.
Yonggang Dai +5 more
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Methodological approach for allele-specific antibody responses to HEK-293T-based cell lines expressing single MHC class I chain-related gene B antigens [PDF]
BMC Molecular and Cell BiologyBackground Antibodies against non-HLA antigens, such as MICA and MICB, have emerged as potential contributors to antibody-mediated rejection and graft failure.
Ji-Ho Jeon +6 more
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Neoantigens and shared MICB α3 antigen dual-targeted vaccine generates potent antitumor immunity [PDF]
EMBO Molecular MedicineImmune suppression is one of the primary obstacles in neoantigen immunotherapy because tumors can rapidly adapt by reducing MHC-I expression or antigen presentation.
Ruijing Tang +13 more
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Immunoproteomic mediators of diabetic peripheral neuropathy: causal insights from Mendelian randomization and single-cell validation [PDF]
Frontiers in ImmunologyObjectiveTo elucidate causal roles of circulating immune cells and plasma proteins in diabetic peripheral neuropathy (DPN) pathogenesis using integrative Mendelian randomization (MR) and single-cell validation.MethodsWe employed two-sample MR to assess ...
Chenhao Hu +8 more
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Therapeutic Targets for Lung Squamous Cell Carcinoma: Proteome‐Wide Mendelian Randomization and Potential Drug Prediction [PDF]
The Clinical Respiratory JournalBackground Lung squamous cell carcinoma (LUSC) is one of the most prevalent subtypes of lung cancer, accounting for approximately 25%. Mendelian randomization (MR) analysis of plasma proteins can identify potential drug targets for LUSC.
Tao Xiang +5 more
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Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor control
Open Research Europe, 2021 Background: MICA and MICB are tightly regulated stress-induced proteins that trigger the immune system by binding to the activating receptor NKG2D on cytotoxic lymphocytes.
Mathieu Bléry +28 more
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Медицинская иммунология, 2022 The MIC genes are located on chromosome 6 in the class I major histocompatibility complex (MHC) region and encode a membrane-bound stress-inducible protein that acts as a ligand to stimulate the NKG2D activating receptor expressed on the surface of the ...
A. L. Burmistrova +3 more
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Remote Sensing, 2023 Developing complex hyperspectral image (HSI) sensors that capture high-resolution spatial information and voluminous (hundreds) spectral bands of the earth’s surface has made HSI pixel-wise classification a reality.
Haron C. Tinega +2 more
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