Results 21 to 30 of about 7,499 (206)
The impact of
HLAMICA polymorphisms have been associated with increased incidence of acute GvHD and adverse outcome in allogeneic haematopoietic stem cell transplantation (HSCT). MICB is another expressed member of MHC class I‐related chain genes and its impact on HSCT outcome is yet to be fully defined.
Elisa Maria Amann +25 more
openaire +4 more sources
Associação entre os genes Mica e Micb e infecções por patógenos intracelulares / Association between Mica and Micb genes and infections by intracellular pathogens [PDF]
, 2022 Os genes MICA e MICB codificam as glicoproteínas expressas constitutivamente em fibroblastos e células epiteliais, no entanto, são sintetizadas como marcadores de estresse celular em condições como o câncer, infecções e doenças autoimunes.
Rodrigues, Amanda Muniz +7 more
core +1 more source
High-Throughput MICA/B Genotyping of Over Two Million Samples: Workflow and Allele Frequencies
Frontiers in Immunology, 2020 MICA and MICB are ligands of the NKG2D receptor and thereby influence NK and T cell activity. MICA/B gene polymorphisms, expression levels and the amount of soluble MICA/B in the serum have been linked to autoimmune diseases, infections, and cancer.
Anja Klussmeier +14 more
doaj +1 more source
MicroRNA-34a promotes MICB expression in hepatocytes [PDF]
Carcinogenesis, 2018 MicroRNA-34a (miR-34a) behaves as a tumor suppressor by decreasing the expression of oncogenes involved in multiple carcinogenic pathways. Intravenous delivery of miR-34a mimics has been investigated in clinical trials as a potential treatment for advanced cancers; however, the effect of miR-34a on cancer immune surveillance is controversial.
Meng-Tao Zhou +16 more
openaire +2 more sources
Indian Journal of Pain, 2022 Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive soft-tissue tumor with a high recurrence rate, often requiring multiple surgeries with multiple sessions of radiotherapy that alters the anatomy and makes regional anesthesia challenging in ...
Debesh Bhoi, Raunak Parida
doaj +1 more source
Effects of Analgesia-Sedation on the Relationship Between NKG2D and Its Ligands MICA, MICB
Cerrahpaşa Medical Journal, 2021 Objective: This study aims to investigate the influence of analgesia-sedation on the expression of natural killer cells, and the NKG2D receptor and MICA/MICB ligand changes in patients who had cerebral digital subtraction angiography for either the ...
Sibel Akyol +3 more
doaj +1 more source
Human Cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against NK cell cytotoxicity. [PDF]
, 2003 The activating receptor, NKG2D, is expressed on a variety of immune effector cells and recognizes divergent families of major histocompatibility complex (MHC) class I-related ligands, including the MIC and ULBP proteins.
Sutherland, CL +13 more
core +1 more source
High MICB expression as a biomarker for good prognosis of colorectal cancer [PDF]
Journal of Cancer Research and Clinical Oncology, 2020 Abstract Introduction Major histocompatibility complex (MHC) plays an important role in colorectal cancer (CRC) immunity. However, the function of MHC class I chain-related B (MICB) molecule is not very clear. In this study, we explored the prognostic effect of MICB in colorectal cancer.
Qingyang Feng +9 more
openaire +2 more sources
, 2013 The polymorphism of major histocompatibility complex class I chain-related gene B (MICB) and variations in MICB alleles in a variety of populations have been characterized using several genotyping approaches.
He, Ji +10 more
core +1 more source
, 2021 NKG2D and its ligands, MICA and MICB, are known as the key regulators of NK cells. NK cells are the first reconstituted cells after the allogeneic hematopoietic stem cell transplantation (HSCT); therefore, it is crucial to understand their role in HSCT ...
Katerina Kratochvilova +21 more
core +1 more source