Results 41 to 50 of about 1,053,112 (188)
Effects of sevoflurane on metalloproteinase and natural killer group 2, member D (NKG2D) ligand expression and natural killer cell-mediated cytotoxicity in breast cancer: an in vitro study [PDF]
Korean Journal of Anesthesiology, 2023 Background We investigated the effects of sevoflurane exposure on the expression of matrix metalloproteinase (MMP), expression and ablation of natural killer group 2, member D (NKG2D) ligands (UL16-binding proteins 1–3 and major histocompatibility ...
Hyae Jin Kim +10 more
doaj +1 more source
Frontiers in Immunology, 2021 Natural killer cells possess key regulatory function in various malignant diseases, including acute myeloid leukemia. NK cell activity is driven by signals received through ligands binding activating or inhibitory receptors.
Alena Machuldova +9 more
doaj +1 more source
Murine cytomegalovirus regulation of NKG2D ligands [PDF]
Medical Microbiology and Immunology, 2008 Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes morbidity risk in immunologically suppressed and immunodeficient patients including congenital infections. Approaches to curb the consequences of HCMV infections are restricted by a lack of complete understanding of viral pathogenesis.
Lenac, Tihana +4 more
openaire +5 more sources
Viruses, 2021 Herpesviruses display a complex and carefully balanced interaction with important players in the antiviral immune response of immunocompetent natural hosts, including natural killer (NK) cells.
Sofie Denaeghel +3 more
doaj +1 more source
NKG2D Ligands Expression and NKG2D-Mediated NK Activity in Sezary Patients [PDF]
Journal of Investigative Dermatology, 2009 Sezary syndrome (SS) is a rare lymphoma characterized by the clonal expansion in the skin and in blood of CD4(+)CD158k(+) T cells. Natural killer (NK) activation against tumors in leukemia models is partly based on the recognition of the target through the NKG2D/NKG2D ligands interactions. We analyzed ex vivo SS malignant lymphocytes for the expression
Dulphy, Nicolas +5 more
openaire +2 more sources
Natural killer cell-mediated shedding of ULBP2. [PDF]
PLoS ONE, 2014 UL16 binding proteins (ULBPs) are a family of cell surface proteins that are present in transformed and stressed cells and ligands for NKG2D. Soluble NKG2D ligands have been found in sera from cancer patients with their protein concentrations correlated ...
Ruipeng Wang, Peter D Sun
doaj +1 more source
Frontiers in Immunology, 2021 The activating immune receptor natural killer group member D (NKG2D) and its cognate ligands represent a fundamental surveillance system of cellular distress, damage or transformation.
Eric Alves +11 more
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The NKG2D ligand ULBP4 is not expressed by human monocytes [PDF]
PLOS ONE, 2020 ABSTRACT The C-type lectin-like receptor NKG2D contributes to the immunosurveillance of virally infected and malignant cells by cytotoxic lymphocytes. A peculiar and puzzling feature of the NKG2D-based immunorecognition system is the high number of ligands for this single immunoreceptor.
Lazarova, Mariya +2 more
openaire +5 more sources
Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells. [PDF]
PLoS ONE, 2015 Several cytotoxic anticancer drugs inhibit DNA replication and/or mitosis, while EGFR tyrosine kinase inhibitors inactivate EGFR signalling in cancer cell.
Riki Okita +13 more
doaj +1 more source
Oncoimmunology, 2017 The introduction of immune checkpoint blockade into the clinical practice resulted in improvement of survival of a significant portion of melanoma patients.
C. Maccalli +15 more
semanticscholar +1 more source