Tumor recognition by natural killer cells in acute myeloid leukemia and after hematopoietic stem cell transplantation [PDF]
, 2005 Natural killer (NK) cell-mediated cytolytic activity against tumors requires the engagement of activating NK cell receptors by the tumor-associated ligands.
Nowbakht, Pegah
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Effects of sevoflurane on metalloproteinase and natural killer group 2, member D (NKG2D) ligand expression and natural killer cell-mediated cytotoxicity in breast cancer: an in vitro study [PDF]
Korean Journal of Anesthesiology, 2023 Background We investigated the effects of sevoflurane exposure on the expression of matrix metalloproteinase (MMP), expression and ablation of natural killer group 2, member D (NKG2D) ligands (UL16-binding proteins 1–3 and major histocompatibility ...
Hyae Jin Kim +10 more
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Immunorecognition of leukemic stem cells by NK cells : the role of HDAC inhibitors in NKG2D ligand-mediated anti-tumor responses in acute myeloid leukemia [PDF]
, 2008 The diagnosis of acute myeloid leukemia (AML) is associated to a poor long-term outcome due to frequent relapse despite intensive chemotherapy, radiation and hematopoietic stem cell transplantation (HSCT) as well as continuous advances in treatment ...
Langenkamp, Ulrich
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Murine cytomegalovirus regulation of NKG2D ligands [PDF]
Medical Microbiology and Immunology, 2008 Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes morbidity risk in immunologically suppressed and immunodeficient patients including congenital infections. Approaches to curb the consequences of HCMV infections are restricted by a lack of complete understanding of viral pathogenesis.
Lenac, Tihana +4 more
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Regulation of expression of ULBP1, a ligand for the activating immunoreceptor NKG2D, and its influence on the cytotoxic function of natural killer cells against human leukemia [PDF]
, 2012 Human natural killer (NK) cells are innate immunity CD56+CD3- lymphocytes, mediating spontaneous killing of tumor-transformed cells. The effector functions of NK cells are regulated by a balance of signals initiated from a variety of activating and ...
Himmelreich, Heike
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NKG2D Ligands Expression and NKG2D-Mediated NK Activity in Sezary Patients [PDF]
Journal of Investigative Dermatology, 2009 Sezary syndrome (SS) is a rare lymphoma characterized by the clonal expansion in the skin and in blood of CD4(+)CD158k(+) T cells. Natural killer (NK) activation against tumors in leukemia models is partly based on the recognition of the target through the NKG2D/NKG2D ligands interactions. We analyzed ex vivo SS malignant lymphocytes for the expression
Dulphy, Nicolas +5 more
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NKG2D-ligands: Putting everything under the same umbrella can be misleading [PDF]
, 2018 NKG2D is a key receptor for the activation of immune effector cells, mainly Natural Killer cells and T lymphocytes, in infection, cancer and autoimmune diseases. Since the detection of ligands for NKG2D in sera of cancer patients is, in many human models,
M. K. Kramer +5 more
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Natural killer cell-mediated shedding of ULBP2. [PDF]
PLoS ONE, 2014 UL16 binding proteins (ULBPs) are a family of cell surface proteins that are present in transformed and stressed cells and ligands for NKG2D. Soluble NKG2D ligands have been found in sera from cancer patients with their protein concentrations correlated ...
Ruipeng Wang, Peter D Sun
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OncoImmunology, 2017 The immune receptor NKG2D is predominantly expressed on NK cells and T cell subsets and confers anti-tumor activity. According to the current paradigm, immune surveillance is counteracted by soluble ligands shed into the microenvironment, which down ...
Maulik Vyas +8 more
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The NKG2D ligand ULBP4 is not expressed by human monocytes [PDF]
PLOS ONE, 2020 ABSTRACT The C-type lectin-like receptor NKG2D contributes to the immunosurveillance of virally infected and malignant cells by cytotoxic lymphocytes. A peculiar and puzzling feature of the NKG2D-based immunorecognition system is the high number of ligands for this single immunoreceptor.
Lazarova, Mariya +2 more
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