Results 61 to 70 of about 381,426 (191)
Journal of Extracellular Vesicles, 2022 Natural killer (NK) cells are innate cytotoxic lymphocytes that play a key role in cancer immunosurveillance thanks to their ability to recognize and kill cancer cells.
Elisabetta Vulpis +20 more
doaj +1 more source
Advanced Science, EarlyView.A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang +8 more
wiley +1 more source
Advanced Science, EarlyView.Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu +9 more
wiley +1 more source
ULBP6/RAET1L is an additional human NKG2D ligand [PDF]
European Journal of Immunology, 2009 AbstractTo date five ULBP/RAET (UL16‐binding protein, also known as retinoic acid early transcript) genes, encoded on human chromosome 6q24.2‐q25.3, have been shown to encode ligands of the activating immunoreceptor NKG2D. Here, we show that a sixth gene, ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript.
Robert A, Eagle +4 more
openaire +2 more sources
Journal for ImmunoTherapy of Cancer, 2021 Background Natural killer group 2D (NKG2D) is an activating receptor of natural killer (NK) cells and other lymphocytes that mediates lysis of malignant cells through recognition of stress-induced ligands such as MICA and MICB.
Congcong Zhang +9 more
doaj +1 more source
Advanced Science, EarlyView.Tools for controlled selenol delivery are crucial for exploring Se‐related biology and medicine, but compound platforms for triggerable release of CH3SeH remain lacking. Herein, we report the first general triggered platform (TD‐MSe) for efficient cyclization release of CH3SeH in live cells.
Wenfang Liang +7 more
wiley +1 more source
NKG2D ligand expression in pediatric brain tumors [PDF]
Cancer Biology & Therapy, 2016 Adult brain tumors establish an immunosuppressive tumor microenvironment as a modality of immune escape, with several immunotherapies designed to overcome this barrier. However, the relationship between tumor cells and immune cells in pediatric brain tumor patients is not as well-defined.
Kristen, Haberthur +11 more
openaire +2 more sources
Expression of the RAE-1 family of stimulatory NK-cell ligands requires activation of the PI3K pathway during viral infection and transformation. [PDF]
PLoS Pathogens, 2011 Natural killer (NK) cells are lymphocytes that play a major role in the elimination of virally-infected cells and tumor cells. NK cells recognize and target abnormal cells through activation of stimulatory receptors such as NKG2D.
Maria Tokuyama +5 more
doaj +1 more source
NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications
Cells, 2021 Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on
Jagoda Siemaszko +2 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu +3 more
wiley +1 more source