Results 51 to 60 of about 1,053,112 (188)

Regulation of ligands for the activating receptor NKG2D

Immunology, 2007
SummaryThe outcome of an encounter between a cytotoxic cell and a potential target cell depends on the balance of signals from inhibitory and activating receptors. Natural Killer group 2D (NKG2D) has recently emerged as a major activating receptor on T lymphocytes and natural killer cells.
Mistry, A, O'Callaghan, C
openaire   +4 more sources

Making Sense of the Diverse Ligand Recognition by NKG2D [PDF]

The Journal of Immunology, 2002
Abstract NKG2D recognizes multiple diverse ligands. Despite recent efforts in determining the crystal structures of NKG2D-ligand complexes, the principle governing this receptor-ligand recognition and hence the criteria for identifying unknown ligands of NKG2D remain central issues to be resolved.
Sergei, Radaev, Michael, Kattah, Zhongcheng, Zou, Marco, Colonna, Peter D, Sun   +4 more
openaire   +2 more sources

Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response

OncoImmunology, 2021
The natural killer group 2 member D (NKG2D) receptor is a C-type lectin-like activating receptor mainly expressed by cytotoxic immune cells including NK, CD8+ T, γδ T and NKT cells and in some pathological conditions by a subset of CD4+ T cells. It binds
Adeline Raynaud, Klervi Desrumeaux, Laurent Vidard, Elise Termine, Daniel Baty, Patrick Chames, Emmanuelle Vigne, Brigitte Kerfelec   +7 more
doaj   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

NKG2D ligand expression in pediatric brain tumors [PDF]

Cancer Biology & Therapy, 2016
Adult brain tumors establish an immunosuppressive tumor microenvironment as a modality of immune escape, with several immunotherapies designed to overcome this barrier. However, the relationship between tumor cells and immune cells in pediatric brain tumor patients is not as well-defined.
Kristen, Haberthur, Kathryn, Brennan, Virginia, Hoglund, Stephanie, Balcaitis, Harrison, Chinn, Amira, Davis, Shannon, Kreuser, Conrad, Winter, Sarah E S, Leary, Gail H, Deutsch, Richard G, Ellenbogen, Courtney A, Crane   +11 more
openaire   +2 more sources

Receptor subtype-dependent effects of propofol on metalloproteinase activity, NKG2D ligand expression, and NK cell-mediated cytotoxicity in breast cancer: an in vitro study [PDF]

Korean Journal of Anesthesiology
Background The effects of propofol, a commonly used intravenous anesthetic, on the breast cancer tumor microenvironment are not well understood. This study examined the influence of propofol on natural killer (NK) group 2, member D (NKG2D) ligand ...
Hyun-Su Ri, Hyeon Jeong Lee, Jaeho Bae, Ah-Reum Cho, Jae Rin Kim, Seungbin Park, Kah Young Lee, Soeun Jeon   +7 more
doaj   +1 more source

Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells. [PDF]

PLoS ONE, 2014
The stimulatory NKG2D receptor on lymphocytes promotes tumor immune surveillance by targeting ligands selectively induced on cancer cells. Progressing tumors counteract by employing tactics to disable lymphocyte NKG2D.
Xin Cai, Zhenpeng Dai, Rebecca S Reeves, Andrea Caballero-Benitez, Kate L Duran, Jeffrey J Delrow, Peggy L Porter, Thomas Spies, Veronika Groh   +8 more
doaj   +1 more source

Radiosensitization effect by HDAC inhibition improves NKG2D-dependent natural killer cytotoxicity in hepatocellular carcinoma

Frontiers in Oncology, 2022
BackgroundHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Radiotherapy (RT) controls HCC unsatisfactorily and temporarily.
Yu-Fan Liu, Yu-Fan Liu, Yun Chiang, Yun Chiang, Feng-Ming Hsu, Feng-Ming Hsu, Chiao-Ling Tsai, Chiao-Ling Tsai, Jason Chia-Hsien Cheng, Jason Chia-Hsien Cheng, Jason Chia-Hsien Cheng   +10 more
doaj   +1 more source

Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity

Journal of Virology, 2017
HIV-1 Nef clones isolated from a rare subset of HIV-1-infected elite controllers (EC), with the ability to suppress viral load to undetectable levels in the absence of antiretroviral therapy, are unable to fully downregulate CD4 from the plasma membrane ...
Nirmin Alsahafi, J. Richard, Jérémie Prévost, M. Coutu, N. Brassard, M. Parsons, D. Kaufmann, M. Brockman, A. Finzi   +8 more
semanticscholar   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source