Results 71 to 80 of about 381,426 (191)

Interleukin‐37 Enhances Liver NK Cell Cytotoxicity and Improves Recurrence‐Free Survival in Hepatocellular Carcinoma Patients

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Introduction Hepatocellular carcinoma (HCC) remains a major cause of cancer‐related mortality worldwide, and postoperative recurrence continues to limit long‐term survival. Liver‐resident natural killer (NK) cells are key effectors of antitumor immunity in the hepatic microenvironment. Interleukin‐37 (IL‐37), an anti‐inflammatory cytokine, has
Yuki Imaoka, Masahiro Ohira, Yuka Tanaka, Toshihiro Nakayama, Miho Akabane, Shinichiro Yokota, Sheri M. Krams, Olivia M. Martinez, Carlos O. Esquivel, Kazunari Sasaki, Hideki Ohdan   +10 more
wiley   +1 more source

NKG2D: Binding Properties for Glycan Ligands, and Mutagenesis Analysis

, 2011
Killer lectin-like receptor NKG2D, which is found on natural killer cells, recognizes MHC class 1-related ligands and also interacts with glycan ligands, heparin-conjugated bovine serum albumin (heparin-BSA) and sialyl Lewis X (sLeX) on multi-antennary N-
Megumi Kimura, Yuzo Imaizumi, Yutaro Azuma, Sayo Matsumoto, Kojiro Matsumoto, Koji Higai, Kazuyuki Yanai   +6 more
core   +1 more source

Herpesviral regulation of the RAE-1 family of NKG2D ligands [PDF]

, 2017
Natural Killer (NK) cells are essential for control of viral infection and cancer. NK cells express NKG2D, an activating receptor that directly recognizes NKG2D ligands.
Greene, Trever T.
core   +1 more source

Intact NKG2D-Independent Function of NK Cells Chronically Stimulated with the NKG2D Ligand Rae-1

, 2010
Human tumors frequently express membrane-bound or soluble NK group 2, member D (NKG2D) ligands. This results in chronic engagement of NKG2D on the surfaces of NK and CD8+ T cells and rapid internalization of the receptor.
Stipan Jonjic, Joshua N. Beilke, Kouetsu Ogasawara, Marine Champsaur, Ulrich H. Koszinowski, Lewis L. Lanier   +5 more
core   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma

Frontiers in Immunology
Chimeric antigen receptor T-cell (CAR-T) therapies have shown promise in glioblastoma clinical studies, but responses remain inconsistent due to heterogeneous tumor antigen expression and immune evasion post-treatment. NKG2D CAR-T cells have demonstrated
Junchen Liu, Junchen Liu, Kun Dai, Kun Dai, Muhammad Auwal Saliu, Muhammad Auwal Saliu, Mansur Dabai Salisu, Mansur Dabai Salisu, Jiangyu Gan, Lukman Olalekan Afolabi, Dehong Yan, Guizhong Zhang, Maoxuan Liu, Maoxuan Liu, Xiaochun Wan, Xiaochun Wan   +15 more
doaj   +1 more source

Treatment‐Free Remission in Chronic Myeloid Leukemia: Toward Precision and Personalized Approaches to Functional Cure

Cancer Science, EarlyView.
Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Hiroshi Ureshino, Shinya Kimura
wiley   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

TIM‐3 Functions as an Activator of NK Cells in GBM and Can Be Upregulated by Torin‐1: Implications for Exogenous NK Cell Transplantation

Immunology, EarlyView.
Unlike generalized mTOR inhibitors, Torin‐1 uniquely drives compensatory upregulation of TIM‐3 on human NK cells, shielding them from immunosuppression while concurrently inhibiting glioblastoma (GBM) growth. Selecting or preconditioning ex vivo NK cell products for high TIM‐3 expression can offer a combination strategy for adoptive cell therapy in GBM.
Yuning Liu, Tram Dao, Shambhavi Borde, Diana Dinh, Sofia Lombardi, Sandra Torregrosa‐Allen, Haley A. Harper, Veronika Slivova, Aaron Cohen‐Gadol, MacKenzie McIntosh, Bennet D. Elzey, Sandro Matosevic   +11 more
wiley   +1 more source