Results 71 to 80 of about 1,053,112 (188)

ULBP6/RAET1L is an additional human NKG2D ligand [PDF]

European Journal of Immunology, 2009
AbstractTo date five ULBP/RAET (UL16‐binding protein, also known as retinoic acid early transcript) genes, encoded on human chromosome 6q24.2‐q25.3, have been shown to encode ligands of the activating immunoreceptor NKG2D. Here, we show that a sixth gene, ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript.
Robert A, Eagle, James A, Traherne, James R, Hair, Insiya, Jafferji, John, Trowsdale   +4 more
openaire   +2 more sources

Human NKG2D-ligands: cell biology strategies to ensure immune recognition

Frontiers in Immunology, 2012
Immune recognition mediated by the activating receptor NKG2D plays an important role for the elimination of stressed cells, including tumours and virus-infected cells.
Lola eFernández-Messina, Hugh T. Reyburn, Mar eVales-Gomez   +2 more
doaj   +1 more source

Functional Repurposing of Magnetic Nanoparticle‐Assisted Hyperthermia for Immune Cell Labelling and Tracking

Small Methods, EarlyView.
We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino   +8 more
wiley   +1 more source

Cervical cancer cell lines expressing NKG2D-ligands are able to down-modulate the NKG2D receptor on NKL cells with functional implications

BMC Immunology, 2012
Background Cervical cancer represents the third most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths in women worldwide.
Jimenez-Perez Miriam I, Jave-Suarez Luis F, Ortiz-Lazareno Pablo C, Bravo-Cuellar Alejandro, Gonzalez-Ramella Oscar, Aguilar-Lemarroy Adriana, Hernandez-Flores Georgina, Pereira-Suarez Ana L, Daneri-Navarro Adrian, del Toro-Arreola Susana   +9 more
doaj   +1 more source

Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models.

European journal of medicinal chemistry, 2016
Hodgkin's lymphoma (HL) is the most common malignant lymphoma in young adults in the western world. This disease is characterized by an overexpression of ADAM-10 with increased release of NKG2D ligands, involved in an impaired immune response against ...
Caterina Camodeca, E. Nuti, L. Tepshi, S. Boero, T. Tuccinardi, E. Stura, A. Poggi, M. Zocchi, A. Rossello   +8 more
semanticscholar   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma

Frontiers in Immunology
Chimeric antigen receptor T-cell (CAR-T) therapies have shown promise in glioblastoma clinical studies, but responses remain inconsistent due to heterogeneous tumor antigen expression and immune evasion post-treatment. NKG2D CAR-T cells have demonstrated
Junchen Liu, Junchen Liu, Kun Dai, Kun Dai, Muhammad Auwal Saliu, Muhammad Auwal Saliu, Mansur Dabai Salisu, Mansur Dabai Salisu, Jiangyu Gan, Lukman Olalekan Afolabi, Dehong Yan, Guizhong Zhang, Maoxuan Liu, Maoxuan Liu, Xiaochun Wan, Xiaochun Wan   +15 more
doaj   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands

mAbs
Natural killer (NK) cells are effector cells of the innate immune system that distinguish between healthy and abnormal cells through activating and inhibitory receptor signaling.
Daniel Fallon, Ching-Shin Huang, Jingya Ma, Christopher Morgan, Zhaohui Sunny Zhou   +4 more
doaj   +1 more source

Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice

Scientific Reports, 2016
Sirt6 is a member of the class III histone deacetylase family which is associated with aging and longevity. Sirt6 deficient mice show an aging-like phenotype, while male transgenic mice of Sirt6 show increased longevity.
Zhu-qin Zhang, Sichong Ren, Ying Tan, Zuo-Zhi Li, Xiaoqiang Tang, Ting-ting Wang, D. Hao, Xiang Zhao, Houzao Chen, De-Pei Liu   +9 more
semanticscholar   +1 more source