Results 91 to 100 of about 381,426 (191)

Table1_MAPK inhibitors dynamically affect melanoma release of immune NKG2D-ligands, as soluble protein and extracellular vesicle-associated.pdf

, 2023
Metastatic melanoma presents, in many cases, oncogenic mutations in BRAF, a MAPK involved in proliferation of tumour cells. BRAF inhibitors, used as therapy in patients with these mutations, often lead to tumour resistance and, thus, the use of MEK ...
Alexandra Beneitez (14429193), Silvia López-Borrego (14429181), Lucía Téllez-Pérez (14429187), Estibaliz Alegre (14429190), Álvaro González (12063540), Amaia Sandúa (12063534), Ricardo Jara-Acevedo (12063543), Annette Paschen (359248), Carmen Campos-Silva (5167676), Tamara Camino (14429184), María Pardo (5654554), Mar Valés-Gómez (4900801)   +11 more
core   +1 more source

Membrane‐Bound Multimodal Plasmonic Transducers for Noninvasive, In Situ Monitoring and Control of CAR T Cells Against Heterogeneous Solid Tumors

Advanced Materials, Volume 38, Issue 58, 16 October 2026.
Membrane‐bound multimodal transducers enable longitudinal ultrasound‐guided photoacoustic monitoring and in situ thermal control of CAR T cells in heterogeneous solid tumors. Imaging correlates T cell trafficking with tumor response, distinguishing responders from nonresponders.
Myeongsoo Kim, Ali Zamat, Melissa Cadena, Chloé Thiveaud, Riya Sen, Jeungyoon Lee, Elif Kulaksizoglu, S. Abbey Oliver, Don VanderLaan, Sydney Fábrega, Zizhen Zha, Kelsey P. Kubelick, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +14 more
wiley   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, Volume 13, Issue 57, 14 October 2026.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Human Dex harbour functional NKG2D ligands.

, 2013
A–B. Immunoblot detection of NKG2D ligands on Dex. (A) 10–40 µg of protein lysates from immature DC (iDC), Dex or tumor cells (K562, GIST) were assayed in western blot analyses using anti-ULBP-1 and MICB Abs on whole protein lysates (A) (this result was ...
Sophie Caillat-Zucman (188152), Laurence Zitvogel (373657), Sophie Viaud (373637), Julien Taieb (232990), Thomas Tursz (373654), Caroline Robert (103600), Magali Terme (373640), Nathalie Chaput (373659), Sophie Novault (373647), Bernard Escudier (373649), Fabrice André (1389063), Caroline Flament (373643)   +11 more
core   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Overview on Epstein–Barr Virus–Host Interactions With a Focus on Host Cell Transcriptome Alterations

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT The Epstein–Barr virus (EBV) belongs to the gamma subgroup of human herpesviruses. EBV is particularly lymphotropic regarding its latency, meaning that it preferentially targets lymphocytes as its immunological niche. During the establishment of the complex virus–host relationships, the virus influences the human host cell transcriptome ...
Louise Wallot, Tim Hohmann, Urszula Hohmann, Faramarz Dehghani, Olaf Grisk, Simon Jasinski‐Bergner   +5 more
wiley   +1 more source

Viral inhibitors of NKG2D ligands: Friends or foes of immune surveillance?

, 2008
NKG2D is a potent activating receptor on NK cells and a co-stimulatory receptor on CD8+ T cells. Through its ability to recognize a panel of ligands inducible by stress or infection, it plays an important role in the control of viral infections.
Krmpotić, Astrid, Astrid Krmpotić, Polić, Bojan, Jonjić, Stipan, Stipan Jonjić, Bojan Polić   +5 more
core   +1 more source

Mechanisms of NKG2D ligand regulation

, 2013
Background: The NKG2D ligands are a set of cell surface proteins, the expression of which can make cells susceptible to immunity mediated by NKG2D receptor expressing cells, which include NK cells, CD8+ αβ T cells and γδ T cells. The NKG2D ligands are known to be expressed in distinct settings, including viral infection, cancer, T cell activation, and ...
McCarthy, M, McCarthy, Michael
openaire   +2 more sources

NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons

Journal of Neuroinflammation
Nociceptors are primary afferent neurons that sense noxious stimuli. They can be activated by tissue injury as well as the accompanying local immune response.
Shuaiwei Wang, Allison M. Barry, Yoon Kyung Lee, Naomi Young, Sang Wook Shim, Xinying Wang, Hyeongcheol Kim, Laura Stirling-Barros, Rafael González-Cano, Michael Costigan, Georgios Baskozos, Simon Rinaldi, David LH Bennett, Seog Bae Oh, Alexander J. Davies   +14 more
doaj   +1 more source

Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys

Heliyon
NKG2D and its ligands are critical regulators of protective immune responses controlling infections and cancer, defining a crucial immune signaling axis. Current therapeutic efforts targeting this axis almost exclusively aim at enhancing NKG2D-mediated effector functions.
Peter B. Rupert, Matthew Buerger, Emily J. Girard, Marie Frutoso, Don Parrilla, Kevin Ng, Theodore Gooley, Veronika Groh, Roland K. Strong   +8 more
openaire   +3 more sources