Results 91 to 100 of about 1,053,112 (188)

Quantification of Rae-1 Staining Intensity in Glomeruli

Bio-Protocol, 2016
NKG2D is expressed on all NK cells and on subsets of NKT, CD8, CD4 and γδ T cells. NKG2D is activated by NKG2D ligands, a stress-induced family of MHC-I-like proteins.
Roberto Spada, Domingo Barber
doaj   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Combinatorial therapy with resveratrol sensitizes glioblastoma to NKG2D CAR-T cells

Frontiers in Immunology
Chimeric antigen receptor T-cell (CAR-T) therapies have shown potential in clinical trials for glioblastoma, yet treatment responses vary due to heterogeneous antigen expression and post-treatment immune escape.
Wei Liang, Wei Liang, Yexiao Tang, Muhammad Auwal Saliu, Muhammad Auwal Saliu, Mansur Dabai Salisu, Mansur Dabai Salisu, Cuimei Chen, Zhiming Xu, Shu Xu, Maoxuan Liu, Maoxuan Liu, Xiaochun Wan, Xiaochun Wan   +13 more
doaj   +1 more source

Development of Chimeric Antigen Receptor‐Modified NK Cells for the Immunotherapy of Adult T‐Cell Leukemia/Lymphoma

European Journal of Haematology, Volume 117, Issue 2, Page 481-491, August 2026.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase expression, representing a potentially tumor‐specific therapeutic target.
Yuichiro Uchida, Seigo Tateo, Masahiro Wakao, Hiroyuki Shinchi, Hayate Sawayama, Akira Fukumoto, Makoto Yoshimitsu, Yasuo Suda   +7 more
wiley   +1 more source

Mechanisms of NKG2D ligand regulation

, 2013
Background: The NKG2D ligands are a set of cell surface proteins, the expression of which can make cells susceptible to immunity mediated by NKG2D receptor expressing cells, which include NK cells, CD8+ αβ T cells and γδ T cells. The NKG2D ligands are known to be expressed in distinct settings, including viral infection, cancer, T cell activation, and ...
McCarthy, M, McCarthy, Michael
openaire   +2 more sources

T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice.

Molecular Therapy, 2015
Ligands for the NKG2D receptor are overexpressed on tumors, making them interesting immunotherapy targets. To assess the tumoricidal properties of T cells directed to attack NKG2D ligands, we engineered murine T cells with two distinct NKG2D-based ...
Heather Vanseggelen, Joanne A. Hammill, A. Dvorkin-Gheva, Daniela Tantalo, J. Kwiecien, G. Denisova, B. Rabinovich, Y. Wan, J. Bramson   +8 more
semanticscholar   +1 more source

Hematopoietic Antigen Presenting Cells Fine‐Tune the Effector Phenotype of Intrathymic Unconventional αβ T Cells

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Our study describes how the effector maturation of intrathymic iNKT and MAIT cells is guided by distinct hematopoietic APCs: DC1s for iNKT cells and macrophages for MAIT cells. ABSTRACT The development of unconventional αβ T cells, including invariant natural killer T (iNKT) and mucosal‐associated invariant T (MAIT) cells, in the thymus is distinct ...
Yi Wang, Trang T. Lam, Sotaro Ochiai, Abbie R. Larson, Dean B. Matthews, Hamish E.G. McWilliam, Tsuneyasu Kaisho, Mireille H. Lahoud, Jose A. Villadangos, Gretchen E. Diehl, Franca Ronchese, Daniel G. Pellicci, Mark M.W. Chong   +12 more
wiley   +1 more source

The Role of Natural Killer (NK) Cells in Dengue Virus Infection: A Narrative Review

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims In the innate immune response, natural Killer (NK) cells have a significant role in protection against viral infections, including the Dengue virus (DENV). NK cells identify and eliminate virus‐infected cells through diverse mechanisms, such as cytokine production, cytolytic activity, and antibody‐dependent cellular ...
Farjana Islam
wiley   +1 more source

Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys

Heliyon
NKG2D and its ligands are critical regulators of protective immune responses controlling infections and cancer, defining a crucial immune signaling axis. Current therapeutic efforts targeting this axis almost exclusively aim at enhancing NKG2D-mediated effector functions.
Peter B. Rupert, Matthew Buerger, Emily J. Girard, Marie Frutoso, Don Parrilla, Kevin Ng, Theodore Gooley, Veronika Groh, Roland K. Strong   +8 more
openaire   +3 more sources

NKG2D Receptor and Its Ligands in Host Defense [PDF]

Cancer Immunology Research, 2015
Abstract NKG2D is an activating receptor expressed on the surface of natural killer (NK) cells, CD8+ T cells, and subsets of CD4+ T cells, invariant NKT cells (iNKT), and γδ T cells. In humans, NKG2D transmits signals by its association with the DAP10 adapter subunit, and in mice alternatively spliced isoforms transmit signals either ...
openaire   +4 more sources